What other drugs will affect Dextrothyroxine Sodium?
Dextrothyroxine Sodium may increase the effects of the following drugs, which could lead to dangerous side effects:
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anticoagulants (blood thinners) such as warfarin (Coumadin), which could lead to bleeding (a dose reduction may be necessary);
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tricyclic antidepressants (TCAs) such as amitriptyline (Elavil), doxepin (Sinequan), and nortriptyline (Pamelor), which could lead to nervousness, a fast heart rate and other side effects;
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other commonly used TCAs, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), protriptyline (Vivactil), and trimipramine (Surmontil); and
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thyroid replacement hormones (Dextrothyroxine Sodium is a form of thyroid hormone and may affect thyroid hormone therapy).
Dextrothyroxine Sodium may decrease the activity of the following drugs:
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antidiabetic agents such as insulin, glyburide (Micronase, Diabeta, Glynase), glipizide (Glucotrol), tolbutamide (Orinase), and tolazamide (Tolinase), which could lead to high blood sugar levels;
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digoxin (Lanoxin, Lanoxicaps) (used to treat heart conditions);
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beta-blockers (used to treat high blood pressure) such as acebutolol (Sectral), propranolol (Inderal) and metoprolol (Lopressor), which could lead to high blood pressure; and
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other commonly used beta-blockers, including betaxolol (Kerlone), carteolol (Cartrol), carvedilol (Coreg), labetalol (Normodyne, Trandate), nadolol (Corgard), pindolol (Visken), and timolol (Blocadren).
The cholesterol-lowering effects of Dextrothyroxine Sodium may be reduced by cholestyramine (Questran), which is another cholesterol-lowering drug. These drugs should not be taken at the same time.
Drugs other than those listed here may also interact with Dextrothyroxine Sodium. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
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Information checked by Dr. Sachin Kumar, MD Pharmacology