Diabitex Side effects

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What are the possible side effects of Diabitex?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Hypoglycemia, or low blood sugar, is the most common side effect of Diabitex. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar.

Stop taking Diabitex and call your doctor at once if you have a serious side effect such as:

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Diabitex in details

A side effect of any drug can be defined as the unwanted or undesired effect produced by the drug. The side effect can be major or in few medications minor that can be ignored. Side effects not only vary from drug to drug, but it also depends on the dose of the drug, the individual sensitivity of the person, brand or company which manufactures it. If side effects overweigh the actual effect of the medicine, it may be difficult to convince the patient to take the drug. Few patients get specific side effects to specific drugs; in that case, a doctor replaces the drug with another. If you feel any side effect and it troubles you, do not forget to share with your healthcare practitioner.
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The majority of the side-effects have been dose-related, transient, and have responded to dose reduction or withdrawal of the medication. However, clinical experience thus far has shown that, as with other sulfonylureas some side-effects associated with hypersensitivity may be severe and deaths have been reported in some instances.

Diabitex has a somewhat higher reported incidence of side-effects than tolbutamide.

Certain untoward reactions associated with idiosyncrasy of hypersensitivity have occurred, including jaundice, skin eruptions rarely progressing to erythema multiforme and exfoliative dermatitis, and probably depression of formed elements of the blood, showing no direct relationship to the size of the dose. They occur characteristically during the first six weeks of therapy. With a few exceptions, these manifestations have been mild and readily reversible on the withdrawal of the drug. Rare cases of phototoxic reactions

have been reported.

The more severe manifestations may require other therapeutic measures, including corticosteroid therapy. Diabitex; should be discontinued promptly when the development of sensitivity is suspected. Jaundice has been reported, and is usually promptly reversible on discontinuance of therapy.

Skin rash may be either the only manifestation of sensitivity, or occur in association with jaundice, frequently preceding it. Low grade fever and eosinophilia may also occur in association with, or preceding the development of clinical jaundice. Rarely, severe diarrhoea, sometimes accompanied by bleeding into the lower bowel and due to nonspecific proctocolitis, has been associated with other hypersensitivity manifestations, particularly jaundice, skin rash, or both. The occurrence, singly or together, of any of these hypersensitivity manifestations, should constitute an indication for prompt termination of the drug and such other therapeutic, measures as are indicated by the circumstances, should be instituted.

Leukopenia, thrombocytopenia and mild anemia, which occur occasionally, are generally benign and revert to normal, following cessation of the drug, leukopenia of mild degree, and not associated with a shift in the differential count, may be transient and frequently reverts to normal even while the drug is continued.

Cases of aplastic anemia and agranulocytosis, generally similar to blood dyscrasias associated with other sulfonylureas have been reported. Lymphocytosis appears to be of no clinical significance. Dose-related side-effects previously mentioned are generally transient and not of a serious nature and would include anorexia, nausea, vomiting, and epigastric discomfort as evidence of gastro-intestinal intolerance, and various vague neurologic symptoms, particularly weakness and paraesthesias. These manifestations are generally a direct function of dosage and were reported much more frequently during the early clinical history of the drug when some clinicians employed relatively high doses.

These side-effects are reversible on reduction of the daily dosage, or if necessary, by withdrawal of the medication.

Diabitex may infrequently induce a syndrome of inappropiate secretion of antidiuretic hormone characterized by water retention, hyponatraemia, and central nervous system signs.

Since animal studies suggest that the action of barbiturates may be prolonged by therapy with Diabitex, barbiturates should be employed with caution.

Similarly, studies showing an exaggerated hypoglycaemic effect of Diabitex in adrenalectomised animals suggest cautious use in patients with Addison’s disease. In some patients, a disulfiram-like reaction may be produced by the ingestion of alcohol. Caution should be exercised when antibacterial sulfonamides, phenylbutazone, salicylates, probenecid, dicoumarol, or MAO inhibitors are administered concomitantly with Diabitex as hypoglycaemia resultant from either potentiation or accumulation of sulfonylureas has been reported. Compounds that may diminish the hypoglycaemic effect and thus cause an increase in the dosage requirement of Diabitex include rifampicin and the thiazide diuretics.

Diabitex should not be used to replace dietetic therapy in the obese.

Ether and suxamethonium antagonise the hypoglycaemic action of Diabitex.

What is the most important information I should know about Diabitex?

When used for long periods of time, Diabitex may not work as well. If your blood sugar has been under control and then becomes hard to manage, contact your doctor. Do not change the dose of your medicine without checking with your doctor.

Diabitex contraindications

Contraindication can be described as a special circumstance or a disease or a condition wherein you are not supposed to use the drug or undergo particular treatment as it can harm the patient; at times, it can be dangerous and life threatening as well. When a procedure should not be combined with other procedure or when a medicine cannot be taken with another medicine, it is called Relative contraindication. Contraindications should be taken seriously as they are based on the relative clinical experience of health care providers or from proven research findings.
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Do not use this medication if you are allergic to Diabitex, or if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin.

Before taking Diabitex, tell your doctor if you have kidney or liver disease, a disorder of your pituitary or adrenal glands, a history of heart disease, or if you are malnourished.

Certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with Diabitex.

Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Signs of blood sugar that is too high (hyperglycemia) may include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Your blood sugar will need to be checked often, and you may need to adjust your Diabitex dose.

Diabitex is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.


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References

  1. DailyMed. "CHLORPROPAMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DTP/NCI. "NSC626720: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
  3. European Chemicals Agency - ECHA. "Chlorpropamide: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Diabitex are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Diabitex. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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