Diazoxide Suspension Uses

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What is Diazoxide Suspension?

Diazoxide Suspension given orally raises blood sugar by slowing the release of insulin from the pancreas.

Diazoxide Suspension is used to treat low blood sugar (hypoglycemia) related to certain cancers that affect the pancreas and cause it to release too much insulin.

Diazoxide Suspension may also be used for purposes other than those listed in this medication guide.

Diazoxide Suspension indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Diazoxide Suspension® (ORAL Diazoxide Suspension) is useful in the management of hypoglycemia due to hyperinsulinism associated with the following conditions:

Adults: Inoperable islet cell adenoma or carcinoma, or extrapancreatic malignancy.
Infants and Children: Leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, or adenomatosis. Diazoxide Suspension® may be used preoperatively as a temporary measure, and postoperatively, if hypoglycemia persists.

Diazoxide Suspension® should be used only after a diagnosis of hypoglycemia due to one of the above conditions has been definitely established. When other specific medical therapy or surgical management either has been unsuccessful or is not feasible, treatment with Diazoxide Suspension® should be considered.

How should I use Diazoxide Suspension?

Use Diazoxide Suspension suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Diazoxide Suspension suspension.

Uses of Diazoxide Suspension in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Hyperinsulinemic hypoglycemia: Management of hypoglycemia due to hyperinsulinism due to the following conditions in adults (ie, inoperable islet cell adenoma or carcinoma, or extrapancreatic malignancy) and infants and children (ie, leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, or adenomatosis; may be used preoperatively as a temporary measure, and postoperatively, if hypoglycemia persists).

Note: Consider treatment with Diazoxide Suspension when other specific medical therapy or surgical management for hypoglycemia due to the above conditions either has been unsuccessful or is not feasible.

Diazoxide Suspension description

A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. [PubChem]

Diazoxide Suspension dosage

Diazoxide Suspension Dosage

Generic name: Diazoxide Suspension

Dosage form: Injection

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Diazoxide Suspension I.V. Injection was originally recommended for use by bolus administration of 300 mg. Recent studies have shown that minibolus administration of Diazoxide Suspension I.V. Injection, ie, doses of 1 to 3 mg/kg repeated at intervals of 5 to 15 minutes is as effective in reducing blood pressure. Minibolus administration usually provides a more gradual reduction in blood pressure and thus may be expected to reduce the circulatory and neurological risks associated with acute hypotension.

Diazoxide Suspension I.V. Injection is administered undiluted and rapidly by intravenous injections of 1 to 3 mg/kg up to a maximum of 150 mg in a single injection. This dose may be repeated at intervals of 5 to 15 minutes until a satisfactory reduction in blood pressure (diastolic pressure below 100 mmHg) has been achieved.

With the patient recumbent, the calculated dose of Diazoxide Suspension I.V. Injection is administered intravenously in 30 seconds or less.

Diazoxide Suspension I.V. Injection should only be given into a peripheral vein. Do not administer it intramuscularly, subcutaneously, or into body cavities. Avoid extravasation of the drug into subcutaneous tissues.

Following the use of Diazoxide Suspension I.V. Injection, the blood pressure should be monitored closely until it has stabilized. Thereafter, measurements taken hourly during the balance of the effect should indicate any unusual response. A further decrease in blood pressure 30 minutes or more after injection should be investigated for causes other than the action of Diazoxide Suspension I.V. Injection. It is preferable that the patient remain supine for at least 1 hour after injection. In ambulatory patients, the blood pressure should also be measured with the patient standing before surveillance is ended.

Repeated administration of Diazoxide Suspension I.V. Injection at intervals of 4 to 24 hours usually will maintain the blood pressure below pretreatment levels until a regimen of oral antihypertensive medication can be instituted. The interval between injections may be adjusted by the duration of the response to each injection. It is usually unnecessary to continue treatment with Diazoxide Suspension I.V. Injection for more than 4 to 5 days.

Since repeated administration of Diazoxide Suspension I.V. Injection can lead to sodium and water retention, administration of a diuretic may be necessary both for maximal blood pressure reduction and to avoid congestive heart failure.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

More about Diazoxide Suspension (Diazoxide Suspension)

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Diazoxide Suspension interactions

See also:
What other drugs will affect Diazoxide Suspension?

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Since Diazoxide Suspension is highly bound to serum proteins, it may displace other substances which are also bound to protein, such as bilirubin or coumarin and its derivatives, resulting in higher blood levels of these substances. Concomitant administration of oral Diazoxide Suspension and diphenylhydantoin may result in a loss of seizure control. These potential interactions must be considered when administering Diazoxide Suspension® Capsules or Suspension.

The concomitant administration of thiazides or other commonly used diuretics may potentiate the hyperglycemic and hyperuricemic effects of Diazoxide Suspension.

Drug/Laboratory Test Interactions

The hyperglycemic and hyperuricemic effects of Diazoxide Suspension preclude proper assessment of these metabolic states. Increased renin secretion, IgG concentrations and decreased cortisol secretions have also been noted. Diazoxide Suspension inhibits glucagon-stimulated insulin release and causes a false-negative insulin response to glucagon.

Diazoxide Suspension side effects

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What are the possible side effects of Diazoxide Suspension?

Applies to Diazoxide Suspension: oral capsule, oral suspension

In addition to its needed effects, some unwanted effects may be caused by Diazoxide Suspension (the active ingredient contained in Diazoxide Suspension). In the event that any of these side effects do occur, they may require medical attention.

Stop taking Diazoxide Suspension and get emergency help immediately if any of the following effects occur:

Rare

Severity: Moderate

If any of the following side effects occur while taking Diazoxide Suspension, check with your doctor or nurse as soon as possible:

More common:

Less common: Rare

Minor Side Effects

Some of the side effects that can occur with Diazoxide Suspension may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

This medicine may cause a temporary increase in hair growth in some people when it is used for a long time. After treatment with Diazoxide Suspension has ended, normal hair growth should return.

Diazoxide Suspension contraindications

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What is the most important information I should know about Diazoxide Suspension?

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You should not take this medication if you are allergic to Diazoxide Suspension or diuretics (water pills).

Oral Diazoxide Suspension should not be used to treat occasional hypoglycemia related to diet.

Before taking Diazoxide Suspension, tell your doctor if you have congestive heart failure, kidney disease, gout, high cholesterol, or low potassium.

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Your doctor may occasionally change your dose to make sure you get the best results from this medication.

If your blood sugar gets too high (hyperglycemia), you may have symptoms such as increased thirst, loss of appetite, fruity breath odor, increased urination, drowsiness, dry skin, nausea, and vomiting. Tell your doctor right away if you have any of these symptoms.

To be sure this medication is helping your condition and not causing harmful effects, your urine will need to be tested often for the presence of glucose (sugar) or ketones. You may be able to do this testing at home. Call your doctor if you have any abnormal test result.

Your doctor may also want you to have blood or urine tests at regular intervals. Do not miss any scheduled appointments.

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are taking Diazoxide Suspension.

If your condition does not improve after taking Diazoxide Suspension for 2 to 3 weeks, stop taking the medication and talk to your doctor.



Active ingredient matches for Diazoxide Suspension:

Diazoxide


List of Diazoxide Suspension substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Injectable; Injection; Diazoxide 300 mg
Injectable; Injection; Diazoxide 15 mg / ml
Proglycem 50 mg/ml Suspension 30ml Bottle$ 197.05
Diazoxide powder$ 85.07
Proglycem 100 mg Capsule$ 1.65
Diazoxide DBL 300 mg/20 mL x 1's
Tablet, Sugar-Coated; Oral; Diazoxide 50 mg (Mercury)
Injectable; Injection; Diazoxide 15 mg / ml (Schering)
20 milliliter in 1 ampule (Schering)
Capsule; Oral; Diazoxide 25 mg (Essex)
Capsule; Oral; Diazoxide 100 mg (Essex)
Proglicem 25 mg x 100's (Essex)
Proglicem 100 mg x 100's (Essex)
Capsule; Oral; Diazoxide 50 mg (Ifet)
Capsule; Oral; Diazoxide 100 mg (Ifet)
Suspension; Oral; Diazoxide 50 mg / ml (Ifet)
Proglycem 50 mg/1 mL x 30 mL (Ifet)
Proglycem suspension 50 mg/mL (Ifet)
Proglycem capsule 100 mg (Ifet)

References

  1. DailyMed. "DIAZOXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "diazoxide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "diazoxide". http://www.drugbank.ca/drugs/DB01119 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Diazoxide Suspension are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Diazoxide Suspension. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported useful

Was the Diazoxide Suspension drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Not useful1
100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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