Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.
Proper storage of Diezar:
Store Diezar at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diezar out of the reach of children and away from pets.
Overdose of Diezar in details
When a dose is taken in higher dose than the recommended doses, it is called Overdose. Overdose always needs a clinical supervision. Any medicine or drug when consumed in Overdose produces untoward side effects on one or various organs in the body. A medicine is excreted in the kidney or metabolized in the liver most of the times. This process goes without any hurdles when taken in normal dose, but when taken in an overdose, the body is not able to metabolize it or send it out properly which causes the effects of anoverdose.
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Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. In humans, experience with intentional overdosage of Diezar is limited.
Single oral doses of Diezar maleate equivalent to 40 mg Diezar/kg and 100 mg Diezar/kg in mice and rats, respectively, caused deaths. Single oral Diezar maleate doses equivalent to 4 or more mg Diezar/kg or higher in dogs (11 or more times the maximum recommended human dose on a mg/m2 basis) caused a marked peripheral vasodilation and hypotension.
If massive overdose should occur, initiate active cardiac and respiratory monitoring. Frequent blood pressure measurements are essential. Should hypotension occur, provide cardiovascular support including elevation of the extremities and the judicious administration of fluids. If hypotension remains unresponsive to these conservative measures, consider administration of vasopressors (such as phenylephrine) with attention to circulating volume and urine output. As Diezar is highly protein bound, hemodialysis is not likely to be of benefit.
What should I avoid while taking Diezar?
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of Diezar.
Diezar warnings
Warnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.
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Hypotension
Symptomatic hypotension is possible, particularly in patients with severe aortic stenosis. Because of the gradual onset of action, acute hypotension is unlikely.
Increased Angina or Myocardial Infarction
Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of Diezar tablets, particularly in patients with severe obstructive coronary artery disease.
Patients with Hepatic Failure
Because Diezar besyaate is extensively metabolized by the liver and the plasma elimination half-life (t1/2) is 56 hours in patients with impaired hepatic function, titrate slowly when administering Diezar to patients with severe hepatic impairment.
What should I discuss with my healthcare provider before taking Diezar?
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For Diezar, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to Diezar or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of Diezar to treat high blood pressure in children younger than 6 years of age. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Diezar in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving Diezar.
Pregnancy
Pregnancy Category
Explanation
All Trimesters
C
Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking Diezar, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using Diezar with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Amiodarone
Atazanavir
Carbamazepine
Ceritinib
Clarithromycin
Clopidogrel
Conivaptan
Dabrafenib
Dantrolene
Dasabuvir
Domperidone
Droperidol
Eliglustat
Eslicarbazepine Acetate
Fentanyl
Idelalisib
Lacosamide
Mitotane
Nilotinib
Ombitasvir
Paritaprevir
Piperaquine
Primidone
Ritonavir
Siltuximab
Simvastatin
St John's Wort
Tacrolimus
Tegafur
Telaprevir
Using Diezar with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Acebutolol
Aceclofenac
Acemetacin
Alprenolol
Amtolmetin Guacil
Aspirin
Atenolol
Avanafil
Betaxolol
Bevantolol
Bisoprolol
Bromfenac
Bucindolol
Bufexamac
Carteolol
Carvedilol
Celecoxib
Celiprolol
Choline Salicylate
Clonixin
Dalfopristin
Dexibuprofen
Dexketoprofen
Diclofenac
Diflunisal
Dilevalol
Diltiazem
Dipyrone
Esmolol
Etodolac
Etofenamate
Etoricoxib
Felbinac
Fenoprofen
Fepradinol
Feprazone
Floctafenine
Fluconazole
Flufenamic Acid
Flurbiprofen
Ibuprofen
Ibuprofen Lysine
Indinavir
Indomethacin
Itraconazole
Ketoconazole
Ketoprofen
Ketorolac
Labetalol
Levobunolol
Lornoxicam
Loxoprofen
Lumiracoxib
Meclofenamate
Mefenamic Acid
Meloxicam
Mepindolol
Metipranolol
Metoprolol
Morniflumate
Nabumetone
Nadolol
Naproxen
Nebivolol
Nepafenac
Niflumic Acid
Nimesulide
Oxaprozin
Oxprenolol
Oxyphenbutazone
Parecoxib
Penbutolol
Phenylbutazone
Piketoprofen
Pindolol
Piroxicam
Proglumetacin
Propionic Acid
Propranolol
Propyphenazone
Proquazone
Quinupristin
Rifapentine
Rofecoxib
Salicylic Acid
Salsalate
Sodium Salicylate
Sotalol
Sulindac
Talinolol
Tenoxicam
Tertatolol
Tiaprofenic Acid
Timolol
Tolfenamic Acid
Tolmetin
Valdecoxib
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of Diezar. Make sure you tell your doctor if you have any other medical problems, especially:
Angina (chest pain) or
Heart attack, acute or
Heart or blood vessel disease (e.g., coronary artery disease) or
Hypotension (low blood pressure)—Use with caution. May make these conditions worse.
Heart disease or other heart problems (e.g., aortic stenosis)—Use with caution. The blood pressure-lowering effects of Diezar may be increased.
Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Diezar precautions
Certain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.
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Concerns related to adverse effects:
• Angina/MI: Increased angina and/or MI have occurred with initiation or dosage titration of dihydropyridine calcium channel blockers. Reflex tachycardia may occur resulting in angina and/or MI in patients with obstructive coronary disease, especially in the absence of concurrent beta-blockade.
• Hypotension: Symptomatic hypotension can occur; acute hypotension upon initiation is unlikely due to the gradual onset of action. Blood pressure must be lowered at a rate appropriate for the patient's clinical condition.
• Peripheral edema: The most common side effect is peripheral edema; occurs within 2 to 3 weeks of starting therapy.
Disease-related concerns:
• Aortic stenosis: Use Diezar with extreme caution in patients with severe aortic stenosis; may reduce coronary perfusion resulting in ischemia.
• Heart failure: With the exception of Diezar, calcium channel blockers should be avoided whenever possible in patients with heart failure with reduced ejection fraction (HFrEF). Diezar may be used for the treatment of hypertension or ischemic heart disease in patients with HFrEF, but has no effect on functional status or mortality (ACCF/AHA [Yancy 2013]).
• Hepatic impairment: Use with caution in patients with hepatic impairment; may require lower starting dose; titrate slowly in patients with severe hepatic impairment.
• Hypertrophic cardiomyopathy (HCM) with outflow tract obstruction: Use Diezar with caution in patients with HCM and outflow tract obstruction since reduction in afterload may worsen symptoms associated with this condition (ACCF/AHA [Gersh 2011]).
Special populations:
•
Elderly: Initiate at a lower dose in the elderly.
Other warnings/precautions:
• Titration: Peak antihypertensive effect is delayed; dosage titration should occur after 7 to 14 days on a given dose.
What happens if I miss a dose of Diezar?
When you miss a dose, you should take it as soon as you remember, but you should take care that it should be well spaced from the next dose. You should not take an extra dose at the time of the second dose as it will become a double dose. The double dose can give unwanted side effects, so be careful. In chronic conditions or when you have a serious health issue, if you miss a dose, you should inform your health care provider and ask his suggestion.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Safe Work Australia - HCIS. "88150-42-9: The Hazardous Chemical Information System (HCIS) at the Safe Work Australia is a database of chemical classifications and workplace exposure standards. It allows users to find information on chemicals that have been classified in accordance with the GHS or which have an Australian Workplace Exposure Standard.". http://hcis.safeworkaustralia.gov.au... (accessed September 17, 2018).
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