Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions.
Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome).
Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis.
Hydrocortisone or cortisone is the drug of choice in primary or secondary adrenocortical insufficiency. Synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance.
To tide the patient over a critical period of the disease in regional enteritis and ulcerative colitis.
Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia.
Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy.
For palliative management of leukemias and lymphomas.
Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy.
Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids.
To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus.
Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis.
As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus.
The intra-articular or soft tissue administration of Injectable Suspension is indicated as adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, synovitis of osteoarthritis.
The intralesional administration of Injectable Suspension is indicated for alopecia areata; discoid lupus erythematosus; keloids; localized hypertrophic, infiltrated, inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus (neurodermatitis), and psoriatic plaques; necrobiosis lipoidica diabeticorum.
Injectable Suspension may also be useful in cystic tumors of an aponeurosis or tendon (ganglia
Each gram of Diprogen cream/ointment contains Betamethasone (Diprogen) dipropionate 640 mcg equivalent to Betamethasone (Diprogen) 500 mcg and Gentamicin (Diprogen) sulfate equivalent to Gentamicin (Diprogen) base 1 mg.
Diprogen cream is an oil-in-water emulsion. It contains mineral oil, white petrolatum and cetostearyl alcohol for its oil phase in emulsion base and chlorocresol as preservative.
Diprogen ointment contains white petrolatum as its excipient.
A thin film of Diprogen should be applied to cover completely the affected area twice daily, in the morning and at night.
Frequency of application should be determined by the physician according to the severity of the condition. For some patients, adequate maintenance therapy may be achieved with less frequent application.
Duration of Treatment: Duration of therapy varies depending upon the extent and location of disease and patient response. However, if clinical improvement is not achieved by 3-4 weeks, diagnosis should be reviewed.
Concurrent use of Phenobarbital, Phenytoin, rifampin or ephedrine may enhance the metabolism of corticosteroids, reducing their therapeutic effects.
Patients receiving both a corticosteroid an estrogen should be observed for excessive corticosteroid effects.
Concurrent use of corticosteroids with potassium-depleting diuretics may enhance
Hypokalemia with cardiac glycosides may enhance the possibility of arrhythmias or digitalis toxicity associated with hypokalemia. Corticosteroids may enhance the potassium depletion caused by amphotericin B. In all patients taking any of these drug therapy combinations, serum electrolyte determinations, particularly potassium levels should be monitored closely.
Concurrent use of corticosteroids with coumarin-type anticoagulants may increase or decrease the anticoagulant effects possibly requiring adjustment in dosage.
Combined effects of non-steroidal anti-inflammatory drugs or alcohol with glucocorticosteroids may result in an increased occurrence or increased severity of gastrointestinal ulceration.
Corticosteroids may decrease blood salicylate concentrations. Acetylsalicylic acid should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.
Dosage adjustments of an antidiabetic drug may be necessary when corticosteroids are given to diabetics.
Concomitant glucocorticosteroid therapy may inhibit the response to somatotropin.
Laboratory test interactions: corticosteroids may affect the nitroblue tetrazolium test for bacterial infection and produce false negative results.
Adverse reactions to Diprogen cream or ointment therapy have been reported very rarely and include hypersensitivity and skin discoloration.
Treatment with Gentamicin (Diprogen) has produced transient irritation (erythema and pruritus) that usually did not require discontinuance of treatment.
Reported adverse reactions with the use of topical corticosteroids, especially under occlusive dressings, include: Burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae and miliaria.
History of sensitivity reactions to Betamethasone (Diprogen), Gentamicin (Diprogen) or to any of the components of Diprogen.
Topical corticosteroids are contraindicated in vaccinia, varicella and tuberculosis of the skin.
Betamethasone/Gentamicin in Kuwait.
|Unit description / dosage (Manufacturer)||Price, USD|
|Cream; Topical; Betamethasone Dipropionate 0.64 mg; Gentamicin Sulfate 1.67 mg / g|
|Ointment; Topical; Betamethasone Dipropionate 0.64 mg; Gentamicin Sulfate 1.67 mg / g|
|Diprogen Beclomethasone dipropionate0.025 %, Gentamicin 0.1 %, Clotrimazole 1 %. CRM / 15g||$ 0.51|
|Diprogen Skin 15 gm Cream||$ 0.51|
|DIPROGEN cream 15g (Indkus)||$ 0.51|
List of Diprogen substitutes (brand and generic names):
|Diprobec 0.025% Lotion (Ranbaxy)||$ 1.39|
|Cream; Topical; Betamethasone Dipropionate 0.05%; Gentamicin Sulfate 0.1%|
|Diprogenta (Argentina, Austria, Bosnia & Herzegowina, Brazil, Bulgaria, Colombia, Croatia (Hrvatska), Germany, Hong Kong, Indonesia, Israel, Malaysia, Peru, Philippines, Poland, Portugal, Romania, Singapore, Slovenia, South Africa, Spain, Switzerland, Taiwan)|
|Cream; Topical; Betamethasone Dipropionate 0.05%; Gentamicin Sulfate 0.1% (Merck Sharp & Dohme)|
|Ointment; Topical; Betamethasone Dipropionate 0.05%; Gentamicin Sulfate 0.1% (Merck Sharp & Dohme)|
|Diprogenta 5 g x 1's (Merck Sharp & Dohme)||$ 4.86|
|Diprogenta 10 g x 1's (Merck Sharp & Dohme)||$ 7.84|
|Diprogenta 5 g (Merck Sharp & Dohme)||$ 7.20|
|Diprogenta 10 g (Merck Sharp & Dohme)||$ 10.83|
|Diprogenta 15 g (Merck Sharp & Dohme)|
|Diprogenta 1 tube 15 g (Merck Sharp & Dohme)|
|Diprogenta 15 g x 1's (Merck Sharp & Dohme)|
|Diprogenta 450 g x 1's (Merck Sharp & Dohme)|
|Diprogenta cream 5 g x 1's (Merck Sharp & Dohme)||$ 9.09|
|Diprogenta oint 5 g x 1's (Merck Sharp & Dohme)||$ 9.09|
|Diprogenta oint 10 g x 1's (Merck Sharp & Dohme)||$ 13.42|
|Diprogenta cream 15 g x 1's (Merck Sharp & Dohme)|
|Diprogenta cream 450 g x 1's (Merck Sharp & Dohme)|
|Diprop. de Betametasona+Sulf Gentamicina EMS (Brazil)|
|Diprop. de Betametasona+Sulf Gentamicina Gen.Germed (Brazil)|
|Diprop. de Betametasona+Sulf Gentamicina Gen.Legrand (Brazil)|
|Diprop. de Betametasona+Sulf Gentamicina GeoLab (Brazil)|
|Diprop. de Betametasona+Sulf Gentamicina Medley (Brazil)|
|Diprop. de Betametasona+Sulf Gentamicina Prati,Donad (Brazil)|
|Diprop. de Betametasona+Sulf Gentamicina Teuto Bras (Brazil)|
|Diprosone G (Mexico)|
|Cream; Topical; Betamethasone Dipropionate 0.05%; Gentamicin Sulfate 0.1% (Schering-plough)|
|Diprospan G (Chile)|
|Cream; Topical; Betamethasone Dipropionate 0.05%; Gentamicin Sulfate 0.1% (Essex)|
|Diprovate-G Betamethasone dipropionate0.05 % w/w, Gentamicinsulphate 0.1 % w/w. CRM / 10g (Fulford)||$ 0.52|
|10g (Fulford)||$ 0.52|
|DIPROVATE-G cream 10g (Fulford)||$ 0.52|
|Aerosol, Metered-Dose; Oral; Beclomethasone Dipropionate 0.05 mg / dose (Salus)|
|Aerosol, Metered-Dose; Oral; Beclomethasone Dipropionate 0.1 mg / dose (Salus)|
|Aerosol, Metered-Dose; Oral; Beclomethasone Dipropionate 0.25 mg / dose (Salus)|
|Dr. Scholl's (Argentina)|
|Drep Clotrimazole 1 % w/v, Beclometasone dipropionate0.025 % w/v, Lidocainehydrochloride 2 % w/v, Ofloxacin 0.3 % w/v. EAR-DPS / 5ml (DWD Pharmaceuticals Ltd.)||$ 0.56|
|5ml (DWD Pharmaceuticals Ltd.)||$ 0.56|
|Drep Ear 5 ml Drop (DWD Pharmaceuticals Ltd.)||$ 0.56|
|DREP EAR DROP 1 packet / 5 ML ear drop each (DWD Pharmaceuticals Ltd.)||$ 0.74|
|DREP ear drops 5ml (DWD Pharmaceuticals Ltd.)||$ 0.56|
|Drep Ear Drop (DWD Pharmaceuticals Ltd.)||$ 0.89|
|DUDERM POWDER (India)|
|DUDERM POWDER topical powd 1 % w/w x 75g (Zenon)|
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Information checked by Dr. Sachin Kumar, MD Pharmacology