The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
Aceclofenac (Dolowin Plus) is a phenylacetic acid derivative that inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. It increases glycosaminoglycans (GAG) synthesis, the principal macromolecule of the extracellular matrix, which aids in repair and regeneration of articular cartilage. Thus, Aceclofenac (Dolowin Plus) has +ve effects on cartilage anabolism combined with modulating effect of matrix catabolism. Paracetamol (Dolowin Plus) has analgesic and antipyretic action with weak anti-inflammatory activity. It produces analgesia by increasing pain threshold and antipyresis by acting on the hypothalamic heat-regulating centre.
Absorption: Aceclofenac (Dolowin Plus): Rapidly absorbed; almost 100% bioavailability; peak plasma levels reached about 1.25-3 hr after oral admin.
Distribution: Aceclofenac (Dolowin Plus): >99.7% bound to plasma proteins; distributes into synovial fluid. Paracetamol (Dolowin Plus): Distributes throughout most fluids of the body.
Excretion: Aceclofenac (Dolowin Plus): About two-thirds of the administered dose is removed in the urine, mainly as conjugated hydroxymetabolites. Paracetamol (Dolowin Plus): Most metabolites are removed in the urine within 24 hr.
EPA DSStox. "Aceclofenac: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
The results of a survey conducted on ndrugs.com for Dolowin Plus are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Dolowin Plus. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
1 consumer reported administration
When best can I take Dolowin Plus, on an empty stomach, before or after food? ndrugs.com website users have also released a report stating that Dolowin Plus should be taken After food. In any case, this may not be the right description on how you ought to take this Dolowin Plus. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Dolowin Plus can be taken.
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