Domitazol Uses

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Consists of Boät Malva, Camphor monobromid, Methylene blue

What is Methylene blue (Domitazol)?

Methemoglobin is a form of hemoglobin (HEEM o glo bin). Hemoglobin is a substance in blood that carries oxygen and distributes it to your tissues and organs. However, methemoglobin is not a type of hemoglobin that is useful in carrying oxygen.

Methemoglobin normally exists in small amounts in the blood. However, when methemoglobin levels increase, the blood is less efficient in circulating oxygen. The resulting lack of oxygen throughout the body can cause symptoms such as pale or blue-colored skin.

Methemoglobinemia is a condition in which methemoglobin is present in high levels in the blood. Methemoglobinemia usually occurs when a person is exposed to certain drugs or chemicals such as nitrites. It may also be caused by a genetic disorder.

Methylene blue (Domitazol) injection is used to treat methemoglobinemia. It works by converting methemoglobin to a more efficient type of hemoglobin to better carry oxygen throughout the body.

Methylene blue (Domitazol) oral is used to treat methemoglobinemia and urinary tract infections. It works as a mild antiseptic to kill bacteria in the urinary tract. You will most likely also be given an antibiotic medication to treat your infection.

Methylene blue (Domitazol) is also used as a dye or staining agent to make certain body fluids and tissues easier to view during surgery or on an x-ray or other diagnostic exam.

Methylene blue (Domitazol) may also be used for purposes not listed in this medication guide.

Methylene blue (Domitazol) indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Methylene blue (Domitazol)™ is indicated for the treatment of pediatric and adult patients with acquired methemoglobinemia.

This indication is approved under accelerated approval. Continued approval for this indication may be contingent upon verification of clinical benefit in subsequent trials.

Uses of Methylene blue (Domitazol) in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use: Labeled Indications

Methemoglobinemia (acquired) (Methylene blue (Domitazol) only): Treatment of pediatric and adult patients with acquired methemoglobinemia

Methemoglobinemia (drug induced) (generic only): Treatment of drug-induced methemoglobinemia

Off Label Uses

Chromoendoscopy (diagnostic aid)

Data from a limited number of patients studied suggest that Methylene blue (Domitazol) may be beneficial for enhancing diagnostic views during chromoendoscopic procedures (eg, esophageal, gastric, colon). Additional trials may be necessary to further define the role of Methylene blue (Domitazol) in the treatment of this condition.

Methylene blue (Domitazol) dosage

Methylene blue (Domitazol) Dosage

Generic name: Methylene blue (Domitazol) 5mg in 1mL

Dosage form: injection

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Dosage and Administration

Preparation and Storage

Each mL of Methylene blue (Domitazol)™ contains 5 mg Methylene blue (Domitazol)

Each 10 mL ampule of Methylene blue (Domitazol)™ contains 50 mg Methylene blue (Domitazol).

Methylene blue (Domitazol)™ is hypotonic and may be diluted before use in a solution of 50 mL 5% Dextrose in Water (D5W) in order to avoid local pain, particularly in the pediatric population. Use the diluted solution immediately after preparation.

Do not mix with sodium chloride 9 mg/mL (0.9%) solution for injection, because it has been demonstrated that chloride reduces the solubility of Methylene blue (Domitazol).

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Keep the ampule in the original package to protect from light.

More about Methylene blue (Domitazol) (Methylene blue (Domitazol))

Consumer resources

Professional resources

Related treatment guides

Methylene blue (Domitazol) interactions

See also:
What other drugs will affect Methylene blue (Domitazol)?

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Serotonergic Drugs

Avoid concomitant use of Methylene blue (Domitazol)™ with medicinal products that enhance serotonergic transmission including SSRIs (selective serotonin reuptake inhibitors), MAO inhibitors, bupropion, buspirone, clomipramine, mirtazapine and venlafaxine; because of the potential for serious CNS reactions, including potentially fatal serotonin syndrome. Although the mechanism is not clearly, understood, literature reports suggest inhibition of MAO by Methylene blue (Domitazol) may be involved. In addition, in vitro studies cannot rule out the potential involvement of CYP 2D6 inhibition by Methylene blue (Domitazol). If the intravenous use of Methylene blue (Domitazol)™ cannot be avoided in patients treated with serotonergic medicinal products, choose the lowest possible dose and observe closely the patient for CNS effects for up to 4 hours after administration.

Agents Metabolized By Cytochrome P450 Enzymes

Methylene blue (Domitazol) inhibits a range of CYP isozymes in vitro, including 1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5. This interaction could be more pronounced with narrow therapeutic index drugs that are metabolized by one of these enzymes (e.g, digoxin, warfarin, phenytoin, alfentanil, cyclosporine, dihydroergotamine, ergotamine, fentanyl, pimozide, quinidine, sirolimus and tacrolimus). However, the clinical relevance of these in vitro interactions is unknown.

Methylene blue (Domitazol) side effects

See also:
What are the possible side effects of Methylene blue (Domitazol)?

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Applies to Methylene blue (Domitazol): intravenous solution

As well as its needed effects, Methylene blue (Domitazol) (the active ingredient contained in Methylene blue (Domitazol)) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking Methylene blue (Domitazol), check with your doctor or nurse immediately:

If any of the following symptoms of overdose occur while taking Methylene blue (Domitazol), get emergency help immediately:

Symptoms of overdose:

Minor Side Effects

Some Methylene blue (Domitazol) side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

Less common:

Methylene blue (Domitazol) contraindications

See also:
What is the most important information I should know about Methylene blue (Domitazol)?

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Do not use Methylene blue (Domitazol) if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Many drugs can interact with Methylene blue (Domitazol). Tell your doctor about all other medications you use. You may need to stop using certain medicines before using Methylene blue (Domitazol) (in some cases for up to 5 weeks before you start Methylene blue (Domitazol)). During your treatment with Methylene blue (Domitazol), do not start or stop using any other medications unless your doctor tells you to.

You should not use this medication if you are allergic to Methylene blue (Domitazol), or if you have severe kidney problems.

Before using Methylene blue (Domitazol), tell your doctor if you have kidney disease, or glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Also tell your doctor about all other medications you use, especially antacids, diuretics (water pills), sodium bicarbonate, or acetazolamide (Diamox).

If you take an antidepressant or psychiatric medication, call your doctor right away if you have signs of a serious drug interaction, including: confusion, memory problems, feeling hyperactive (mentally or physically), loss of coordination, muscle twitching, shivering, sweating, diarrhea, and/or fever.

Methylene blue (Domitazol) will most likely cause your urine or stools to appear blue or green in color. This is a normal side effect of the medication and will not cause any harm.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using Methylene blue (Domitazol).

Call your doctor at once if you have a serious side effect such as severe vomiting or stomach pain, pain in your chest or behind your breast bone, pale or blue skin, high fever, fast or pounding heartbeats, trouble breathing, confusion, or feeling like you might pass out.



Active ingredient matches for Domitazol:

Boät Malva/Camphor monobromid/Methylene blue in Vietnam.


Unit description / dosage (Manufacturer)Price, USD
Domitazol 5 Blister x 10 Tablet

List of Domitazol substitutes (brand and generic names):

Misol Blue TV Pharm 5 Blister x 10 Tablet
Tiphamisol blue 5 Blister x 10 Tablet
Tiphamisol blue 1 Bottle 100 Tablet

References

  1. DailyMed. "METHYLENE BLUE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "methylene blue". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "methylene blue". http://www.drugbank.ca/drugs/DB09241 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Domitazol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Domitazol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

2 consumers reported useful

Was the Domitazol drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Useful2
100.0%


4 consumers reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Domitazol drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Not expensive2
50.0%
Expensive2
50.0%


8 consumers reported time for results

To what extent do I have to use Domitazol before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Domitazol. To get the time effectiveness of using Domitazol drug by other patients, please click here.
Users%
1 day2
25.0%
2 weeks1
12.5%
5 days1
12.5%
> 3 month1
12.5%
3 month1
12.5%
1 week1
12.5%
3 days1
12.5%


22 consumers reported age

Users%
16-299
40.9%
46-606
27.3%
> 604
18.2%
30-453
13.6%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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