Dorpep Uses

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What is Dorpep?

Dorpep is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Dorpep affects chemicals in the brain that may become unbalanced and cause anxiety.

Dorpep is used to treat anxiety disorders or alcohol withdrawal.

Dorpep may also be used for other purposes not listed in this medication guide.

Dorpep indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Dorpep (Dorpep) is indicated for the management of anxiety disorders or for the short term relief of symptoms of anxiety, withdrawal" symptoms of acute alcoholism, and preoperative apprehension and anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.

The effectiveness of Dorpep (Dorpep) in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.

How should I use Dorpep?

Use Dorpep injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Dorpep injection is usually administered as an injection at your doctor's office, hospital, or clinic.
  • If you are using Dorpep injection at home, carefully follow the injection procedures taught to you by your health care provider.
  • If the medicine contains particles or is discolored, or if the vial/container is cracked or damaged in any way, do not use it.
  • Try to stay in bed for 3 hours after taking Dorpep injection.
  • Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
  • If you miss a dose of Dorpep injection and you are using it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dorpep injection.

Uses of Dorpep in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Dorpep is used to treat anxiety and acute alcohol withdrawal. It is also used to relieve fear and anxiety before surgery. This medication belongs to a class of drugs called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA).

How to use Dorpep

Take this medication by mouth as directed by your doctor. The dosage is based on your age, medical condition, and response to treatment.

Use this medication exactly as prescribed. Do not increase your dose, take it more frequently or use it for a longer period of time than prescribed because this drug can be habit-forming. Also, if used for an extended period of time, do not suddenly stop using this drug without your doctor's approval. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased to avoid side effects such as seizures.

When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well.

Dorpep description

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A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Dorpep has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Dorpep is a controlled substance in the U.S.

Dorpep dosage

Because of the wide range of clinical indications for Dorpep (Dorpep), the optimum dosage varies with the diagnosis and response of the individual patient. The dosage, therefore, should be individualized for maximum beneficial effects.

ADULTS USUAL DAILY DOSE
Relief of Mild and Moderate Anxiety Disorders and Symptoms of Anxiety 5 mg or 10 mg, 3 or 4 times daily
Relief of Severe Anxiety Disorders and Symptoms of Anxiety 20 mg or 25 mg, 3 or 4 times daily
Geriatric Patients, or in the presence of debilitating disease. 5 mg, 2 to 4 times daily

Preoperative Apprehension and Anxiety: On days preceding surgery, 5 to 10 mg orally, 3 or 4 times daily. If used as preoperative medication, 50 to 100 mg IM* 1 hour prior to surgery.

PEDIATRIC PATIENTS USUAL DAILY DOSE
Because of the varied response of pediatric patients to CNS-acting drugs, therapy should be initiated with the lowest dose and increased as required. Since clinical experience in pediatric patients under 6 years of age is limited, the use of the drug in this age group is not recommended. 5 mg, 2 to 4 times daily (may be increased in some pediatric patients to 10 mg, 2 to 3 times daily)

For the relief of withdrawal symptoms of acute alcoholism, the parenteral form* is usually used initially. If the drug is administered orally, the suggested initial dose is 50 to 100 mg, to be followed by repeated doses as needed until agitation is controlled up to 300 mg per day. Dosage should then be reduced to maintenance levels.

* See package insert for Injectable Dorpep (Dorpep HCI).

How supplied

Dorpep (Dorpep HCI) Capsules are available in the following presentations:

5 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3750-10), with Dorpep (Dorpep) 5 imprinted on the opaque green cap and ICN imprinted on the opaque yellow body.

10 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3751-10), with Dorpep (Dorpep) 10 imprinted on the opaque black cap and ICN imprinted on the opaque green body.

25 mg hard gelatin capsules in bottles of 100 (NDC-0187- 3758-10), with Dorpep (Dorpep) 25 imprinted on the opaque green cap and ICN imprinted on the opaque white body.

Store at 25°C (77°F); excursions permitted to 15°C - 30°C (59°F - 86°F).

Vaieant Pharmaceuticals International Costa Mesa, CA 92626. Rev. July 2005. FDA rev date: 9/6/2002

Dorpep interactions

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What other drugs will affect Dorpep?

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When this drug applied simultaneously with:

- antipsychotic drugs (neuroleptics), antidepressants, sedatives, hypnotics, anesthetics, analgesics, ethanol enhanced the inhibitory effect on central nervous system, especially when administered parenterally.

- concomitant use of antacids can delay but not reduce the absorption of Dorpep.

- hormonal contraceptives increases the effectiveness of Dorpep.

- with muscle relaxants may enhance the action of muscle relaxants, with levodopa - may suppress antiparkinsonian action.

- theophylline at low doses perverts sedative effect of Dorpep.

- phenobarbital and phenytoin may accelerate the metabolism of Dorpep. In rare cases this medication inhibits the metabolism and enhances the action of phenytoin.

- may increase the toxicity of cyclophosphamide.

- cimetidine, omeprazole, disulfiram may increase the intensity and duration of action of this medicine.

Dorpep side effects

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What are the possible side effects of Dorpep?

The necessity of discontinuing therapy because of undesirable effects has been rare. Drowsiness, ataxia and confusion have been reported in some patients particularly the elderly and debilitated. While these effects can be avoided in almost all instances by proper dosage adjustment, they have occasionally been observed at the lower dosage ranges. In a few instances syncope has been reported.

Other adverse reactions reported during therapy include isolated instances of skin eruptions, edema, minor menstrual irregularities, nausea and constipation, extrapyramidal symptoms, as well as increased and decreased libido. Such side effects have been infrequent, and are generally controlled with reduction of dosage. Changes in EEG patterns (low-voltage fast activity) have been observed in patients during and after Dorpep (Dorpep) treatment.

Blood dyscrasias (including agranulocytosis), jaundice and hepatic dysfunction have occasionally been reported during therapy. When Dorpep (Dorpep) treatment is protracted, periodic blood counts and liver function tests are advisable.

DRUG ABUSE AND DEPENDENCE: Dorpep hydrochloride capsules are classified by the Drug Enforcement Administration as a Schedule IV controlled substance.

Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol (convulsions, tremor, abdominal and muscle cramps, vomiting and sweating), have occurred following abrupt discontinuance of Dorpep. The more severe withdrawal symptoms have usually been limited to those patients who had received excessive doses over an extended period of time. Generally milder withdrawal symptoms (eg, dysphoria and insomnia) have been reported following abrupt discontinuance of benzodiazepines taken continuously at therapeutic levels for several months. Consequently, after extended therapy, abrupt discontinuation should generally be avoided and a gradual dosage tapering schedule followed. Addiction-prone individuals (such as drug addicts or alcoholics) should be under careful surveillance when receiving Dorpep or, other, psychotropic agents because of the predisposition of such patients to habituation and dependence.

Dorpep contraindications

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What is the most important information I should know about Dorpep?

Do not use this medication if you are allergic to Dorpep or to other benzodiazepines, such as alprazolam (Xanax), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

This medication can cause birth defects in an unborn baby. Do not use Dorpep if you are pregnant.

Before taking Dorpep, tell your doctor if you have any breathing problems, glaucoma, porphyria, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.

Do not drink alcohol while taking Dorpep. This medication can increase the effects of alcohol.

Tell your doctor if you regularly use other medicines that make you sleepy. They can add to sleepiness caused by Dorpep.

Dorpep may be habit-forming and should be used only by the person it was prescribed for. Dorpep should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.



Active ingredient matches for Dorpep:

Chlordiazepoxide in India.

Clidinium bromide in India.


Unit description / dosage (Manufacturer)Price, USD
Dorpep Clidinium bromide 2.5 mg, Chlordiazepoxide 5 mg. TAB / 10
10's
DORPEP tab 10's (Candor (Aileron))

List of Dorpep substitutes (brand and generic names):

10 mg x 10's (East West)$ 0.38
25 mg x 10's (East West)$ 0.55
Ebrium 10mg TAB / 10 (East West)$ 0.38
Ebrium 25mg TAB / 10 (East West)$ 0.55
EBRIUM tab 10 mg x 10's (East West)$ 0.38
EBRIUM tab 25 mg x 10's (East West)$ 0.55
Ebrium 10mg TAB / 10 (East West)$ 0.38
Ebrium 25mg TAB / 10 (East West)$ 0.55
Eden 50mg x 5mL TAB / 30ml (Eden)$ 0.71
50 mg x 5 mL x 30ml (Eden)$ 0.71
Tablets; Oral; Cefixime 50 mg (Eden)
EDEN SYRUP 1 bottle / 30 ML syrup each (Eden)$ 0.49
EDEN dry syr 50 mg x 5 mL x 30ml (Eden)$ 0.71
Eden NA Syrup (Eden)$ 0.49
Tablet, Film-Coated; Oral; Chlordiazepoxide 10 mg (Polfa Tarchomin)
Tablets, Film-Coated; Oral; Chlordiazepoxide 10 mg (Polfa Tarchomin)
Equicalm Trifluoperazine hydrochloride1 mg, Chlordiazepoxide 10 mg. FC-TAB / 200 (Ultramark)$ 4.32
200's (Ultramark)$ 4.32
Equicalm Trifluoperazine hydrochloride1 mg, chlordiazepoxide 10 mg. SC-TAB / 200 (Ultramark)$ 4.32
EQUICALM sugar-coated tab 10's (Ultramark)$ 0.22
EQUILIBRIUM Capsule/ Tablet / 10mg / 10 units (Jagsonpal)$ 0.33
Equilibrium 10mg TAB / 10 (Jagsonpal)$ 0.46
10 mg x 10's (Jagsonpal)$ 0.46
Tablets; Oral; Chlordiazepoxide 10 mg (Jagsonpal)
EQUILIBRIUM 10 MG TABLET 1 strip / 10 tablets each (Jagsonpal)$ 0.71
EQUILIBRIUM tab 10 mg x 10's (Jagsonpal)$ 0.46
Equilibrium 10mg Tablet (Jagsonpal)$ 0.07
Febl Forte 25+10 Tablet (Forgo Pharmaceuticals (P) Ltd.)$ 0.05
Fit Trifluoperazine 1 mg, Chlordiazepoxide 10 mg. TAB / 100 (East African (I) Remedies Pvt Ltd)$ 1.90
100's (East African (I) Remedies Pvt Ltd)$ 1.90
FIT 10+1 Tablet (East African (I) Remedies Pvt Ltd)$ 0.02
FIT 1MG/10MG TABLET 1 strip / 10 tablets each (East African (I) Remedies Pvt Ltd)$ 2.10
FIT tab 10's (East African (I) Remedies Pvt Ltd)$ 0.19
Fit 10 mg/1 mg Tablet (East African (I) Remedies Pvt Ltd)$ 0.21
Gispa 2.5+5 Tablet (Lifecom Pharmaceuticals (I) Pvt Ltd)$ 0.03
Gutbest 2.5+5 Tablet (Grefith Life Sciences)$ 0.05
Gutbest D 2.5+10+10 Tablet (Grefith Life Sciences)$ 0.06
Gutrex 5+2.5 Tablet (Tas Med (I) Pvt. Ltd.)$ 0.04

References

  1. DailyMed. "AMITRIPTYLINE HYDROCHLORIDE; CHLORDIAZEPOXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "clidinium". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. PubChem. "chlordiazepoxide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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