Doxamicina Uses

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What is Doxamicina?

Doxamicina injection is used to treat bacterial infections in many different parts of the body. It belongs to the group of medicines called antibiotics. Doxamicina works by killing bacteria or preventing their growth. However, Doxamicina will not work for colds, flu, or other virus infections.

Doxamicina is available only with your doctor's prescription.

Doxamicina indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Doxamicina for injection is indicated for the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli. It is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa. This antibiotic is not indicated for infections due to Proteus or Neisseria. Doxamicina for injection has proven clinically effective in treatment of infections due to the following gram-negative organisms: Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

Doxamicina for injection may be used to initiate therapy in serious infections that are suspected to be due to gram-negative organisms and in the treatment of infections due to susceptible gram-negative pathogenic bacilli.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Doxamicina for injection and other antibacterial drugs, Doxamicina for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

How should I use Doxamicina?

Use Doxamicina as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Doxamicina is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Doxamicina at home, a health care provider will teach you how to use it. Be sure you understand how to use Doxamicina. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • To clear up your infection completely, use Doxamicina for the full course of treatment. Keep using it even if you feel better in a few days.
  • Do not use Doxamicina if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Doxamicina, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Doxamicina.

Uses of Doxamicina in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This combination medication is used to treat tension headaches. Acetaminophen helps to decrease the pain from the headache. Caffeine helps increase the effects of acetaminophen. Butalbital is a sedative that helps to decrease anxiety and cause sleepiness and relaxation.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat migraine headaches.

How to use Bac

Take this medication by mouth with or without food as directed by your doctor, usually every 4 hours as needed.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your medical condition, age, and response to treatment. This medication works best if it is used as the first signs of a headache occur. If you wait until the headache has worsened, the medication may not work as well.

This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as nausea/vomiting, mental/mood changes, seizures) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Report any withdrawal reactions right away.

Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior (addiction). This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction.

Tell your doctor if you notice increased use of this medication, a worsening of headaches, an increase in the number of headaches, the medication not working as well, or use of this medication for more than 2 headache episodes a week. Do not take more than recommended. Your doctor may need to change your medication and/or add a separate medication to prevent the headaches.

Doxamicina description

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Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Doxamicina sulfate, nonsteriles A, B, and C) which act as detergents on cell membranes. Doxamicina sulfate, nonsterile is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.

Doxamicina dosage

Important: Doxamicina for injection is supplied in vials containing Doxamicina sodium equivalent to 150 mg Doxamicina base activity per vial.

Reconstitution for

Intravenous or

Intramuscular Administration: The 150 mg vial should be reconstituted with 2 mL Sterile Water for Injection, USP.

The reconstituted solution provides Doxamicina sodium at a concentration equivalent to 75 mg/mL Doxamicina base activity.

During reconstitution swirl gently to avoid frothing.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. If these conditions are observed, the product should not be used.

Dosage

Adults and pediatric patients –

Intravenous or

Intramuscular Administration: The dose of Doxamicina for injection should be 2.5 to 5 mg/kg per day of Doxamicina base in 2 to 4 divided doses for patients with normal renal function, depending on the severity of the infection.

In obese individuals, dosage should be based on ideal body weight.

The daily dose and frequency should be reduced for the patients with renal impairment. Suggested modifications of dosage schedule for patients with renal impairment are presented in Table 1.

TABLE 1. Suggested Modification of Dosage Schedules of Doxamicina for Injection for Adults with Impaired Renal Function

Degree of Renal Impairment

Normal

Mild

Moderate

Severe

Creatinine Clearance (mL/min)

≥80

50-79

30-49

10-29

Dosage Schedule

2.5 – 5 mg/kg, divided into 2 to 4 doses per day

2.5-3.8 mg/kg, divided into 2 doses per day

2.5 mg/kg, once daily or divided into 2 doses per day

1.5 mg/kg every 36 hours

Note: The suggested total daily dose is calculated from Doxamicina base activity.

INTRAVENOUS ADMINISTRATION

1. Direct Intermittent Administration—Slowly inject one-half of the total daily dose over a period of 3 to 5 minutes every 12 hours.

2. Continuous Infusion—Slowly inject one-half of the total daily dose over 3 to 5 minutes. Add the remaining half of the total daily dose of Doxamicina for injection to one of the following:

0.9% NaCl

5% dextrose in 0.9% NaCl

5% dextrose in water

5% dextrose in 0.45% NaCl

5% dextrose in 0.225% NaCl

Lactated Ringer’s solution

10% invert sugar solution

There are not sufficient data to recommend usage of Doxamicina for injection with other drugs or other than the above listed infusion solutions.

Administer the second half of the total daily dose by slow intravenous infusion, starting 1 to 2 hours after the initial dose, over the next 22 to 23 hours. In the presence of impaired renal function, reduce the infusion rate depending on the degree of renal impairment.

The choice of intravenous solution and the volume to be employed are dictated by the requirements of fluid and electrolyte management.

Any final intravenous infusion solution containing Doxamicina sodium should be freshly prepared and used for no longer than 24 hours.

INTRAMUSCULAR ADMINISTRATION

1. For

Intramuscular Injection, administer by deep intramuscular injection into a large muscle mass (such as the gluteal muscles or lateral part of the thigh).

Store reconstituted solution for intramuscular injection in a refrigerator 2° to 8°C (36° to 46°F) or between 20° to 25°C (68° to 77°F) and use within 7 days.

Doxamicina interactions

See also:
What other drugs will affect Doxamicina?

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Aminoglycosides: May enhance the nephrotoxic effect of Doxamicina. Aminoglycosides may enhance the neuromuscular-blocking effect of Doxamicina. Management: Avoid coadministration of Doxamicina and aminoglycosides whenever possible due to the risk of nephrotoxicity and neuromuscular blockade. If coadministration cannot be avoided, monitor renal and neuromuscular function. Consider therapy modification

Amphotericin B: May enhance the nephrotoxic effect of Doxamicina. Management: Avoid coadministration of Doxamicina and amphotericin B whenever possible due to the potential for additive or synergistic nephrotoxicity. If coadministration cannot be avoided, closely monitor renal function. Consider therapy modification

Bacitracin (Systemic): Doxamicina may enhance the nephrotoxic effect of Bacitracin (Systemic). Avoid combination

BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Avoid combination

BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Monitor therapy

Capreomycin: May enhance the neuromuscular-blocking effect of Doxamicina. Monitor therapy

Cefazedone: May enhance the nephrotoxic effect of Doxamicina. Monitor therapy

Cephalothin: May enhance the nephrotoxic effect of Doxamicina. Monitor therapy

Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Avoid combination

Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Monitor therapy

Mecamylamine: Doxamicina may enhance the neuromuscular-blocking effect of Mecamylamine. Avoid combination

Methoxyflurane: Doxamicina may enhance the nephrotoxic effect of Methoxyflurane. Avoid combination

Neuromuscular-Blocking Agents: Doxamicina may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents. Management: If possible, avoid concomitant use of these products. Monitor for deeper, prolonged neuromuscular-blocking effects (respiratory paralysis) in patients receiving concomitant neuromuscular-blocking agents and Doxamicina. Consider therapy modification

Polymyxin B: May enhance the neuromuscular-blocking effect of Doxamicina. Monitor therapy

Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Consider therapy modification

Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Use of this vaccine should be postponed until at least 3 days after cessation of antibacterial agents. Consider therapy modification

Vancomycin: May enhance the nephrotoxic effect of Doxamicina. Management: Avoid coadministration of Doxamicina and vancomycin whenever possible due to the potential for additive or synergistic nephrotoxicity. If coadministration cannot be avoided, closely monitor renal function. Consider therapy modification

Doxamicina side effects

See also:
What are the possible side effects of Doxamicina?

Applies to Doxamicina: injection powder for solution

In addition to its needed effects, some unwanted effects may be caused by Doxamicina. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking Doxamicina, check with your doctor or nurse immediately:

Incidence not known:

  • Blood in the urine
  • bluish lips or skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in frequency of urination or amount of urine
  • decrease in amount of urine
  • difficulty with breathing
  • drowsiness
  • fever
  • increased thirst
  • loss of appetite
  • nausea or vomiting
  • shortness of breath
  • slurred speech
  • swelling of the feet or lower legs
  • tightness in the chest
  • tingling of the arms, legs, and tongue
  • troubled breathing
  • weakness
  • wheezing

If any of the following symptoms of overdose occur while taking Doxamicina, get emergency help immediately:

Symptoms of overdose:

  • Dizziness
  • mood or mental changes
  • shakiness and unsteady walk
  • uncontrolled eye movements
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Minor Side Effects

Some of the side effects that can occur with Doxamicina may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:

  • Diarrhea
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • hives or welts
  • itching
  • redness of the skin
  • sensation of spinning
  • stomach cramps or pain

Doxamicina contraindications

See also:
What is the most important information I should know about Doxamicina?

Hypersensitivity to Doxamicina, Doxamicina, or any component of the formulation

Active ingredient matches for Doxamicina:

Colistin in Italy.


List of Doxamicina substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Dilozol C NA Suspension (Simpson Brawn Pharmaceuticals)$ 0.44
GD SAFE 12.5 MG DRY SYRUP 1 bottle / 30 ML dry syrup each (Ind Swift Laboratories Ltd)$ 0.61
GD SAFE 12.5 MG SYRUP 1 bottle / 30 ML syrup each (Ind Swift Laboratories Ltd)$ 0.67
GD SAFE 25 MG DRY SYRUP 1 bottle / 30 ML dry syrup each (Ind Swift Laboratories Ltd)$ 0.82
GD Safe 12.5mg Syrup (Ind Swift Laboratories Ltd)$ 0.67
GD Safe 25mg Dry Syrup (Ind Swift Laboratories Ltd)$ 0.82
Guficol 1Million IU Injection (Gufic Bioscience Ltd)$ 7.92
Guficol 2Million IU Injection (Gufic Bioscience Ltd)$ 14.27
Guficol 3Million IU Injection (Gufic Bioscience Ltd)$ 20.62
Guficol Plus 1Million IU Injection (Gufic Bioscience Ltd)$ 11.90
Guficol Plus 2Million IU Injection (Gufic Bioscience Ltd)$ 24.18
HICOLY 1 MIU INJECTION 1 vial / 1 injection each (Intas Pharmaceuticals Ltd)$ 12.61
HICOLY 2 MIU INJECTION 1 vial / 1 injection each (Intas Pharmaceuticals Ltd)$ 13.67
HICOLY 3MILLIONIU INJECTION 1 vial / 1 injection each (Intas Pharmaceuticals Ltd)$ 35.43
Hicoly 1miu Injection (Intas Pharmaceuticals Ltd)$ 12.61
Hicoly 2miu Injection (Intas Pharmaceuticals Ltd)$ 13.67
HOPSTIN 1MIU INJECTION 1 vial / 1 ML injection each (Micro Labs Ltd)$ 8.03
HOPSTIN FORTE 2MIU INJECTION 1 vial / 2 ML injection each (Micro Labs Ltd)$ 14.96
ICUSTIN TM 1000000IU INJECTION 1 vial / 1 injection each (Abbott India Ltd)$ 13.75
IYSTIN 12.5MG SUSPENSION 1 bottle / 30 ML suspension each (Thrift Pharmaceuticals)$ 0.56
IYSTIN DS 12.5MG SUSPENSION 1 bottle / 30 ML suspension each (Thrift Pharmaceuticals)$ 0.75
Iystin DS 12.5mg Suspension (Thrift Pharmaceuticals)$ 0.75

References

  1. PubChem. "colistin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "Colistin". http://www.drugbank.ca/drugs/DB00803 (accessed September 17, 2018).
  3. MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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