When a dose is taken in higher dose than the recommended doses, it is called Overdose. Overdose always needs a clinical supervision. Any medicine or drug when consumed in Overdose produces untoward side effects on one or various organs in the body. A medicine is excreted in the kidney or metabolized in the liver most of the times. This process goes without any hurdles when taken in normal dose, but when taken in an overdose, the body is not able to metabolize it or send it out properly which causes the effects of anoverdose.
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Nausea, vomiting, vasomotor flushes, blurred vision, spots or flashes, scotomata, ovarian enlargement with pelvic or abdominal pain. GI decontamination in addition to supportive measures.
Dufine warnings
Warnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.
f flutamide is used for a lengthy period of time, make sure that contraception is adequate in connection with a possible effect of flutamide on sperm. This only applies in patients who have not undergone a surgical castration as part of the treatment of prostate cancer.
Special Patient Groups: Patients suffering from reduced liver and/or kidney function may likely experience problems when using flutamide. If the patient is suffering from cardiovascular diseases, the risk exists of retaining fluid during flutamide treatment. Consult the doctor if the patient’s liver or kidney function is deteriorating or if the patient’s cardiovascular problems increase when using flutamide.
Effects on the Ability to Drive or Operate Machinery: No data are available on the effect of flutamide on the ability to drive or operate machines. An effect, however, is not expected.
Use in pregnancy & lactation: Not applicable since flutamide is only used in men.
Use in children: Flutamide tablets are not intended for children. Pregnancy category D
Dufine precautions
Certain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.
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Dufine should be used cautiously in patients with known hypersensitivity to pituitary gonadotropin eg, patients with polycystic ovary syndrome.
Patient with ovarian cyst should not use Dufine, since it may cause enlargement of the ovaries.
Patients should always be monitored for signs of excessive ovarian stimulation (eg, pelvic pain) during Dufine therapy.
If ovulary enlargement or cyst formation has occurred, therapy should be discontinued until the size of the ovary returns to normal, and the dose or duration of the continuing therapy should be reduced.
If any visual disturbances have occurred during Dufine treatment, it should be discontinued and complete ophthalmologic evaluation should be performed.
Effects on the Ability to Drive or Operate Machinery: Caution should be taken if the job of the patients need a high degree of alertness or high level of mental and physical conditions.
