Duinum 50mg Uses
is used to induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant. Clomiphene is in a class of medications called ovulatory stimulants. It works similarly to estrogen, a female hormone that causes eggs to develop in the ovaries and be released.
Clomiphene is also sometimes used to treat male infertility, menstrual abnormalities, fibrocystic breasts, and persistent breast milk production. Talk to your doctor about the possible risks of using this medication for your condition.
Duinum 50mg is used to treat infertility in women caused by failure or improper release of eggs from ovary (ovulation).It is also used to treat infertility in males due to decreased production of sperms (oligozoospermia).
A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. [PubChem]
Once ovulation has been established, start each course of Duinum 50mg on or about the 5th day of cycle. Max: 6 cycles (including 3 ovulatory cycles).
* If you think you might be pregnant, stop taking this medicine and tell your doctor. Talk to your doctor before taking this medicine if you have thyroid problems. Multiple births (such as twins or triplets) are possible when taking clomiphene. This medicine may cause changes in vision such as blurring or trouble focusing.
* If this becomes severe, tell your doctor.
* Be careful driving or operating machinery.
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
Long-term use of clomiphene may increase the risk of ovarian cancer. Clomiphene should not be used for more than about six cycles. Talk to your doctor about the risks of taking this medication.
Clomiphene may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
this medicine is contraindicated in patients with a known hypersensitivity or allergy to clomiphene citrate or to any of its ingredients.
this medicine should not be administered during pregnancy. this medicine may cause fetal harm in animals. Although no causative evidence of a deleterious effect of CLOMID therapy on the human fetus has been established, there have been reports of birth anomalies which, during clinical studies, occurred at an incidence within the range reported for the general population. To avoid inadvertent this medicine administration during early pregnancy, appropriate tests should be utilized during each treatment cycle to determine whether ovulation occurs. The patient should be evaluated carefully to exclude pregnancy, ovarian enlargement, or ovarian cyst formation between each treatment cycle. The next course of this medicine therapy should be delayed until these conditions have been excluded.
Fetal/Neonatal Anomalies and Mortality. The following fetal abnormalities have been reported subsequent to pregnancies following ovulation induction therapy with this medicine during clinical trials. Each of the following fetal abnormalities were reported at a rate of < 1% (experiences are listed in order of decreasing frequency): Congenital heart lesions, Down syndrome, club foot, congenital gut lesions, hypospadias, microcephaly, harelip and cleft palate, congenital hip, hemangioma, undescended testicles, polydactyly, conjoined twins and teratomatous malformation, patent ductus arteriosus, amaurosis, arteriovenous fistula, inguinal hernia, umbilical hernia, syndactyly, pectus excavatum, myopathy, dermoid cyst of scalp, omphalocele, spina bifida occulta, ichthyosis, and persistent lingual frenulum. Neonatal death and fetal death/stillbirth in infants with birth defects have also been reported at a rate of < 1%. The overall incidence of reported birth anomalies from pregnancies associated with maternal CLOMID ingestion during clinical studies was within the range of that reported for the general population.
In addition, reports of birth anomalies have been received during postmarketing surveillance of this medicine.
Oral administration of clomiphene citrate to pregnant rats during organogenesis at doses of 1 to 2 mg/kg/day resulted in hydramnion and weak, edematous fetuses with wavy ribs and other temporary bone changes. Doses of 8 mg/kg/day or more also caused increased resorptions and dead fetuses, dystocia, and delayed parturition, and 40 mg/kg/day resulted in increased maternal mortality. Single doses of 50 mg/kg caused fetal cataracts, while 200 mg/kg caused cleft palate.
Following injection of clomiphene citrate 2 mg/kg to mice and rats during pregnancy, the offspring exhibited metaplastic changes of the reproductive tract. Newborn mice and rats injected during the first few days of life also developed metaplastic changes in uterine and vaginal mucosa, as well as premature vaginal opening and anovulatory ovaries. These findings are similar to the abnormal reproductive behavior and sterility described with other estrogens and antiestrogens.
In rabbits, some temporary bone alterations were seen in fetuses from dams given oral doses of 20 or 40 mg/kg/day during pregnancy, but not following 8 mg/kg/day. No permanent malformations were observed in those studies. Also, rhesus monkeys given oral doses of 1.5 to 4.5 mg/kg/day for various periods during pregnancy did not have any abnormal offspring.
Liver Disease. this medicine therapy is contraindicated in patients with liver disease or a history of liver
Clomifene in Vietnam.
List of Duinum 50mg substitutes (brand and generic names)
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|Unit description / dosage (Manufacturer)||Price, USD|
|Duinum (Bahrain, Cyprus, Singapore, Sri Lanka, Sudan, Thailand, Vietnam)|
|Duinum tab 50 mg 1 x 10's (Medochemie)|
|ENCLOVA 100 MG TABLET 1 strip / 5 tablets each (Dr. Johns Laboratories Pvt Ltd)||$ 5.56|
|ENCLOVA 50 MG TABLET 1 strip / 5 tablets each (Dr. Johns Laboratories Pvt Ltd)||$ 3.16|
|Enova 25mg Tablet (Bsp Pharmaceuticals)||$ 0.03|
|Enova 50mg Tablet (Bsp Pharmaceuticals)||$ 0.08|
|ENOVA 25 MG TABLET 1 strip / 10 tablets each (Bsp Pharmaceuticals)||$ 0.34|
|ENOVA 50 MG TABLET 1 strip / 10 tablets each (Bsp Pharmaceuticals)||$ 0.82|
|Fensipros 50 mg x 10's (Pharos)||$ 11.25|
|Tablet; Oral; Clomiphene Citrate 50 mg (Arrow)|
|FERPILL KIT 50 MG TABLET 1 strip / 15 tablets each (Intas Pharmaceuticals Ltd)||$ 3.17|
|Ferpill Kit 50mg Tablet (Intas Pharmaceuticals Ltd)||$ 0.21|
|Fertab 50mg (Oman)|
|Fertex 50mg TAB / 10 (HLL Lifecare)||$ 0.95|
|Fertex 100mg TAB / 10 (HLL Lifecare)||$ 0.95|
|FERTEX 50MG TABLET 1 strip / 10 tablets each (HLL Lifecare)||$ 0.95|
|FERTEX tab 50 mg x 10's (HLL Lifecare)||$ 0.95|
|FERTEX tab 100 mg x 10's (HLL Lifecare)||$ 0.95|
|Fertex 50mg Tablet (HLL Lifecare)||$ 0.10|
|FERTEX M 25MG TABLET 1 strip / 30 tablets each (Hindustan Latex Ltd)||$ 1.52|
|Fertex-M 25mg TAB / 10 (HLL Lifecare)||$ 1.52|
|FERTEX-M tab 25 mg x 10's (HLL Lifecare)||$ 1.52|
|Ferticlo 50 mg x 20's||$ 1.78|
|Fertifact 50mg TAB / 10 (Medico HC)||$ 0.95|
|50 mg x 10's (Medico HC)||$ 0.95|
|FERTIFACT tab 50 mg x 10's (Medico HC)||$ 0.95|
|FERTIL tab 50 mg x 10's (Systemic)|
|Fertilan (China, Hong Kong)|
|Fertilan 50 mg x 10's (Codal synto)|
|Fertilphen 50 mg x 10's (Landson)||$ 11.98|
|Fertin (Bulgaria, Indonesia, Latvia)|
|Fertin 50 mg x 10's (Interbat)||$ 9.92|
|Fertomid (India, South Africa)|
|FERTOMID Capsule/ Tablet / 100mg / 5 units (Cipla Limited)||$ 0.86|
|FERTOMID Capsule/ Tablet / 50mg / 10 units (Cipla Limited)||$ 1.10|
|FERTOMID Capsule/ Tablet / 25mg / 10 units (Cipla Limited)||$ 0.56|
|Fertomid 25mg TAB / 10 (Cipla Limited)||$ 0.64|
|Fertomid 50mg TAB / 10 (Cipla Limited)||$ 1.20|
|Fertomid 100mg TAB / 5 (Cipla Limited)||$ 0.86|
|25 mg x 10's (Cipla Limited)||$ 0.64|
|50 mg x 10's (Cipla Limited)||$ 1.20|
|100 mg x 5's (Cipla Limited)|
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Information checked by Dr. Sachin Kumar, MD Pharmacology