Dumin Pregnancy

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Pregnancy of Dumin in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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Dumin has been assigned to pregnancy category C by the FDA. Animal studies have shown a decrease in survival rate of newborn rats and potential for cataract formation for the survivors. There are no controlled data in human pregnancy. Dumin should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Based on data from animal studies, increased uterine resistance is expected in humans. Low dose Dumin (1 to 5 mcg per kg per minute), however, has been used safely to increase urine output in six oliguric women with preeclampsia without significantly altering maternal central venous or pulmonary capillary wedge blood pressures or causing fetal harm. It has also been safely used to treat hypotension in pregnant women during Cesarean section without causing adverse effects in the fetuses, newborns, or mothers.

See references

Dumin breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

There are no data on the excretion of Dumin into human milk. The manufacturer recommends that caution be used when administering Dumin to nursing women.

See references

References for pregnancy information

  1. Fishburne JI, Dormer KJ, Payne GG, Gill PS, Ashrafzadeh AR, Rossavik IK "Effects of amrinone and Dumin on uterine blood flow and vascular responses in the gravid baboon." Am J Obstet Gynecol 158 (1988): 829-37
  2. Kirshon B, Lee W, Mauer MB, Cotton DB "Effects of low-dose Dumin therapy in the oliguric patient with preeclampsia." Am J Obstet Gynecol 159 (1988): 604-7

References for breastfeeding information

  1. "Product Information. Intropin (Dumin)." DuPont Pharmaceuticals, Wilmington, DE.


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References

  1. PubMed Health. "Dopamine (By injection): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  2. Human Metabolome Database (HMDB). "Dopamine: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
  3. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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