Overdose of Dumolid in details
Symptoms: CNS depression of varying severity - lethargy, weakness, severe drowsiness, deep sleep, confusion, decreased response to painful stimuli; in more severe cases - ataxia, areflexia, hypotension, respiratory depression and cardiac activity, coma.
Treatment: induction of vomiting or gastric lavage, activated charcoal technique, monitoring vital signs, symptomatic therapy, intravenous fluids, if necessary - mechanical ventilation. As a specific antidote used benzodiazepine receptor antagonist flumazenil (in hospital).
Dumolid warnings
How to use Dumolid :Use clotrimazole exactly as directed by your doctor. Always read the manufacturers information leaflet, if possible, before beginning treatment. Dumolid preparations are usually applied two to three times a day until the infection has cleared. This medicine is for you. Never give it to others, even if their condition appears to be the same as yours. Getting the most from your treatment : Always wash and dry your hands thoroughly before and after handling clotrimazole. Do not allow clotrimazole to come into contact with the eyes, ears, or mucous membranes (eg. mouth, vagina, inside of nose etc.), unless you are advised to do so by your doctor. Complete the full course of treatment with clotrimazole, otherwise your infection is likely to recur. Before using any over-the-counter medicines, check with your pharmacist which medicines are safe for you to use alongside clotrimazole. You should see an improvement in your condition after a few days. If your condition does not seem to be getting better after seven days, consult your doctor for advice.
Dumolid precautions
May induce anterograde amnesia; caution patients to have uninterrupted sleep of 7-8 hr after ingestion of dose. May impair ability to drive or operate machinery. Depression, especially if suicidal risk may be present. History of drug abuse or acute alcoholism. Hepatic and renal impairment. Respiratory disease. Debilitated patients. Patients who are at risk of falls. Children, elderly. Pregnancy and lactation.
References
- DrugBank. "nitrazepam". http://www.drugbank.ca/drugs/DB01595 (accessed September 17, 2018).
- MeSH. "Hypnotics and Sedatives". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
- Burnham Center for Chemical Geno. "SID50086824: Aqueous solubility in buffer at pH 7.4". https://pubchem.ncbi.nlm.nih.gov/bio... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
