Dyrect Uses

• Diclofenac (Dyrect) indications
• Uses of Diclofenac (Dyrect) in details
• Diclofenac (Dyrect) description
• Diclofenac (Dyrect) dosage
• Diclofenac (Dyrect) interactions
• Diclofenac (Dyrect) side effects
• Diclofenac (Dyrect) contraindications
• Serratiopeptidase (Dyrect) indications
• Uses of Serratiopeptidase (Dyrect) in details
• Serratiopeptidase (Dyrect) description
• Serratiopeptidase (Dyrect) dosage
• Serratiopeptidase (Dyrect) interactions
• Serratiopeptidase (Dyrect) side effects

Consists of diclofenac, serratiopeptidase

What is Diclofenac (Dyrect)?

Diclofenac (Dyrect) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, Diclofenac (Dyrect) does not cure osteoarthritis and will help you only as long as you continue to use it.

Diclofenac (Dyrect) topical 3% gel is also used to treat actinic keratosis, a skin problem that may become cancerous if not treated. The exact way that topical Diclofenac (Dyrect) helps this condition is unknown.

Diclofenac (Dyrect) topical solution is used to treat pain and swelling caused by osteoarthritis of the knees.

Diclofenac (Dyrect) topical patch is used to treat acute pain caused by minor strains, sprains, and contusions (bruises).

Diclofenac (Dyrect) is available only with your doctor's prescription.

Diclofenac (Dyrect) indications

Intramuscular

Renal colic

Adult: As Diclofenac (Dyrect) Na: 75 mg, may repeat once after 30 min if needed. Max: 150 mg/day. Max period: 2 days.

Intramuscular

Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea

Adult: As Diclofenac (Dyrect) Na: 75 mg once daily, injected into the gluteal muscle, may increase to 75 mg bid in severe conditions. Max period: 2 days.

Intravenous

Postoperative pain

Adult: As Diclofenac (Dyrect) Na: 75 mg infusion in glucose 5% or NaCl 0.9% (previously buffered w/ Na bicarbonate) given over 30-120 min or as bolus inj, may repeat after 4-6 hr if necessary. Max period: 2 days.

Intravenous

Prophylaxis of postoperative pain

Adult: As Diclofenac (Dyrect) Na: Initially, 25-50 mg infusion given after surgery over 15-60 min followed by 5 mg/hr. Alternatively, initial dose may be given as bolus inj over 5-60 sec followed by additional inj, may repeat after 4-6 hr if necessary. Max: 150 mg/day. Max period: 2 days.

Ophthalmic

Postoperative ocular inflammation

Adult: As Diclofenac (Dyrect) Na (0.1% soln): Instill into the appropriate eye 4 times daily starting 24 hr after surgery for up to 28 days.

Ophthalmic

Inflammation and discomfort after strabismus surgery

Adult: As Diclofenac (Dyrect) Na (0.1% soln): Instill 1 drop 4 times daily for the 1st wk; then tid in the 2nd wk, bid in the 3rd wk, and as required for the 4th wk.

Ophthalmic

Pain and discomfort after radial keratotomy

Adult: As Diclofenac (Dyrect) Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.

Ophthalmic

Pain after accidental trauma

Adult: As Diclofenac (Dyrect) Na (0.1% soln): Instill 1 drop 4 times daily for up to 2 days.

Ophthalmic

Control of inflammation after argon laser trabeculoplasty

Adult: As Diclofenac (Dyrect) Na (0.1% soln): Instill 1 drop 4 times during the 2 hr before procedure followed by 1 drop 4 times daily, up to 7 days after procedure.

Ophthalmic

Prophylaxis of intra-operative miosis

Adult: As Diclofenac (Dyrect) Na (0.1% soln): Instill into appropriate eye 4 times w/in 2 hr before surgery.

Ophthalmic

Post-photorefractive keratectomy pain

Adult: As Diclofenac (Dyrect) Na (0.1% soln): Instill into the affected eye twice, an hr before surgery, then 1 drop twice at 5-min intervals immediately after surgery, then every 2-5 hr while awake for up to 24 hr.

Ophthalmic

Seasonal allergic conjunctivitis

Adult: As Diclofenac (Dyrect) Na (0.1% soln): Instill 1 drop before surgery followed by 1 drop immediately after surgery, and then 1 drop 4 times daily for up to 2 days.

Oral

Bursitis, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis, Acute gout, Dysmenorrhoea

Adult: As Diclofenac (Dyrect) Na: 75-150 mg/day in divided doses. Max: 150 mg/day.

Oral

Migraine

Adult: As Diclofenac (Dyrect) K: Initially, 50 mg taken at the 1st sign of an attack, an additional dose of 50 mg may be taken after 2 hr if symptoms persist. If needed, further doses of 50 mg may be taken 4-6 hrly. Max: 200 mg/day.

Rectal

Acute gout, Bursitis, Dysmenorrhoea, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis, Sprains, Strains, Tendinitis

Adult: As Diclofenac (Dyrect) Na: 100 mg once daily.

Topical/Cutaneous

Actinic keratoses

Adult: As Diclofenac (Dyrect) Na (3% gel): Apply bid for 60-90 days.

Topical/Cutaneous

Osteoarthritis

Adult: As Diclofenac (Dyrect) Na (1.6% soln): Apply in small amounts (20 or 40 drops) onto affected area 4 times daily. As Na: (1% gel): Apply to the affected area 4 times daily. Max: 32 g/day over the affected area.

Topical/Cutaneous

Local symptomatic relief of pain and inflammation

Adult: As Diclofenac (Dyrect) Na (1% gel): Apply onto affected area 3 or 4 times daily.

Transdermal

Acute pain

Adult: Sprains, strains, contusions: 1 patch bid.

How should I use Diclofenac (Dyrect)?

Use Diclofenac (Dyrect) solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Diclofenac (Dyrect) solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Diclofenac (Dyrect) solution refilled.
• Do not apply Diclofenac (Dyrect) solution to infected skin; open wounds; or red, swollen, or peeling skin.
• Wash your hands immediately before and after using Diclofenac (Dyrect) solution.
• Wash the affected area and dry completely before using Diclofenac (Dyrect) solution.
• To apply Diclofenac (Dyrect) solution, dispense 10 drops at a time onto the knee or into your hand. Spread Diclofenac (Dyrect) solution evenly around the front, back, and sides of the knee. Repeat until you have used the whole dose.
• Be sure that you cover your entire knee with your dose of Diclofenac (Dyrect) solution. Do not use more than the recommended amount.
• Do not apply sunscreens, cosmetics, insect repellants, other topical medicines, or any other substance to the treated area until it is completely dry.
• Do not put on clothes over the treated area until it is completely dry.
• Do not wrap, bandage, or apply heat to the treated area.
• Let the treated skin dry before touching it or letting it touch anyone else's skin.
• Do not shower, bathe, or wash the treated area for at least 30 minutes after you use Diclofenac (Dyrect) solution.
• If you miss a dose of Diclofenac (Dyrect) solution, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Diclofenac (Dyrect) solution.

Uses of Diclofenac (Dyrect) in details

Diclofenac (Dyrect) is used to relieve pain from various conditions. This form of Diclofenac (Dyrect) is used to treat migraine headaches. Diclofenac (Dyrect) is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation. This effect helps to decrease swelling, pain, or fever.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat gout attacks.

How to use Diclofenac (Dyrect)

Read the Medication Guide provided by your pharmacist before you start taking Diclofenac (Dyrect) and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor. Empty the contents of one packet into a cup containing 1 to 2 ounces (30 to 60 milliliters) of water. Mix well and drink all of it right away. Do not mix with any liquid other than water. If stomach upset occurs while taking this medication, take it with food, milk, or an antacid. However, if you take this medication with a meal high in fat, it may not work as well.

There are different brands and forms of this medication available. Because different forms do not have the same effects at equal strengths, do not switch forms of Diclofenac (Dyrect) unless your doctor tells you to.

To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose. Do not increase your dose or take it more often than prescribed.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your condition persists or worsens.

Diclofenac (Dyrect) description

The active substance is sodium-[o[(2,6-dichlorophenyl)-amino]-phenyl]-acetate (= Diclofenac (Dyrect) sodium).

Each enteric tablet contains 25 mg or 50 mg of Diclofenac (Dyrect) sodium.

One prolonged-release tablet contains 100 mg of Diclofenac (Dyrect) sodium.

Excipients/Inactive Ingredients: Gastro-Resistant Tablet: Core for 25 mg and 50 mg: Cellulose microcrystalline; lactose monohydrate; magnesium stearate; maize starch; povidone; silica, colloidal anhydrous; sodium starch glycolate (type A).

Coating for 25 mg and 50 mg: Hypromellose; iron oxide yellow (E172); macrogoglycerol hydroxystearate; methacrylic acid-ethyl acrylate copolymer; macrogol 8000; talc; titanium dioxide (E171); simeticone; alpha-octadecyl-omega-hydroxy-polyglykolether; sorbic acid.

Coating for 50 mg: Iron oxide red (E172).

SR Tablet: Tablet Core: Cetyl alcohol; magnesium stearate; povidone; silica; colloidal anhydrous; sucrose.

Tablet Coating: Hypromellose; iron oxide red (E172); macrogol 8000; polysorbate 80; sucrose; talc; titanium dioxide (E171). Printing Ink: Carbon black, shellac, ammonium hydroxide, simethicone.

Injection: Each ampoule also contains the following excipients: Mannitol, sodium metabisulfite (E223), benzyl alcohol, propylene glycol, water for injection, sodium hydroxide.

Diclofenac (Dyrect) dosage

General Dosing Instructions

Carefully consider the potential benefits and risks of Diclofenac (Dyrect) and other treatment options before deciding to use Diclofenac (Dyrect). Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.

The effectiveness of Diclofenac (Dyrect) when taken with food has not been studied in clinical studies. Taking Diclofenac (Dyrect) with food may cause a reduction in effectiveness compared to taking Diclofenac (Dyrect) on an empty stomach.

Acute Pain

For management of mild to moderate acute pain, the dosage is 18 mg or 35 mg orally three times daily.

Osteoarthritis Pain

For management of osteoarthritis pain, the dosage is 35 mg orally three times daily.

Dosage Adjustments in Patients with Hepatic Impairment

Patients with hepatic disease may require reduced doses of Diclofenac (Dyrect) compared to patients with normal hepatic function. As with other Diclofenac (Dyrect) products, start treatment at the lowest dose. If efficacy is not achieved with the lowest dose, discontinue use.

Non-Interchangeability with Other Formulations of Diclofenac (Dyrect)

Diclofenac (Dyrect) capsules are not interchangeable with other formulations of oral Diclofenac (Dyrect) even if the milligram strength is the same. Diclofenac (Dyrect) capsules contain Diclofenac (Dyrect) free acid whereas other Diclofenac (Dyrect) products contain a salt of Diclofenac (Dyrect), i.e., Diclofenac (Dyrect) potassium or sodium. A 35 mg dose of Diclofenac (Dyrect) is approximately equal to 37.6 mg of sodium Diclofenac (Dyrect) or 39.5 mg of potassium Diclofenac (Dyrect). Therefore, do not substitute similar dosing strengths of other Diclofenac (Dyrect) products without taking this into consideration.

Diclofenac (Dyrect) interactions

See also:
What other drugs will affect Diclofenac (Dyrect)?

Aspirin: Concomitant administration of Diclofenac (Dyrect) and aspirin is not recommended because Diclofenac (Dyrect) is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels and AUC values.

Anticoagulants: While studies have not shown Diclofenac (Dyrect) to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. Because prostaglandins play an important role in hemostasis and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including Diclofenac (Dyrect) and warfarin, requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.

Digoxin, Methotrexate, Cyclosporine: Diclofenac (Dyrect), like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Ingestion of Diclofenac (Dyrect) may increase serum concentrations of digoxin and methotrexate and increase cyclosporine's nephrotoxicity. Patients who begin taking Diclofenac (Dyrect) or who increase their Diclofenac (Dyrect) dose or any other NSAID while taking digoxin, methotrexate or cyclosporine may develop toxicity characteristics for these drugs. They should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.

Lithium: Diclofenac (Dyrect) decreases lithium renal clearance and increases lithium plasma levels. In patients taking Diclofenac (Dyrect) and lithium concomitantly, lithium toxicity may develop.

Oral Hypoglycemics:

Diclofenac (Dyrect) does not alter glucose metabolism in normal subjects nor does it alter the effects of oral hypoglycemic agents. There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of Diclofenac (Dyrect) that necessitated changes in the doses of such agents. Both hypo- and hyperglycemic effects have been reported. A direct causal relationship has not been established, but physicians should consider the possibility that Diclofenac (Dyrect) may alter a diabetic patient's response to insulin or oral hypoglycemic agents.

Diuretics: Diclofenac (Dyrect) and other NSAIDs can inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.

Other Drugs: In small groups of patients (7-10/interaction study), the concomitant administration of azathioprine, gold, chloroquine, D-penicillamine, prednisolone, doxycycline or digitoxin did not significantly affect the peak levels and AUC values of Diclofenac (Dyrect). Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of Diclofenac (Dyrect) therapy.

Diclofenac (Dyrect) side effects

See also:
What are the possible side effects of Diclofenac (Dyrect)?

There have been cases reported of Diclofenac (Dyrect) being associated with the development of symptoms resembling the syndrome of inappropriate antidiuretic hormone secretion in elderly women. A patient who had been taking Diclofenac (Dyrect) for several years and had increasingly complained of dry, gritty eyes noticed that eye irritation disappeared within 3 days when Diclofenac (Dyrect) had to be discontinued because of GI effects.

The most frequent adverse effects reported in patients given Diclofenac (Dyrect) are GI in nature. Typical reactions include epigastric pain, nausea, vomiting and diarrhoea. Rarely, peptic ulcer and GI bleeding have occurred. Diclofenac (Dyrect) has also been implicated as the causative agent in colonic ulceration, small bowel perforation and pseudomembranous colitis.

Renal papillary necrosis and nephritic syndrome have been reported in patients taking Diclofenac (Dyrect). Elevations of serum aminotransferase activity and clinical hepatitis, including fetal fulminant hepatitis have occurred in patients taking Diclofenac (Dyrect). Self-limiting skin reaction eg, rash or pruritus may occur in patients given Diclofenac (Dyrect).

Aspirin-sensitive asthmatic patients have developed reactions (rhinorrhoea, tightness of chest, wheezing, dyspnoea) when challenged with Diclofenac (Dyrect) in doses of 10-25 mg and the CMS in the UK have received a report of 1 aspirin-sensitive patient who died from acute asthma 4 hrs after a single 25-mg dose of Diclofenac (Dyrect).

Diclofenac (Dyrect) contraindications

See also:
What is the most important information I should know about Diclofenac (Dyrect)?

Hypersensitivity to Diclofenac (Dyrect) sodium or to any of the excipients of Diclofenac (Dyrect).

Active gastric or intestinal ulcer, bleeding or perforation.

Last trimester of pregnancy.

Hepatic, renal and severe cardiac failure.

Patients in whom attacks of asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid and/or other drugs with prostaglandin-synthetase inhibitory activity.

Treatment of peri-operative pain in setting of coronary artery bypass graft (CABG) surgery.

The use of high dose Diclofenac (Dyrect) (150 mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension.

Established Cardiovascular Disease or Significant Cardiovascular Risk Factors: The use of high dose Diclofenac (Dyrect) (150mg/day) for >4 weeks is contraindicated in patients with established cardiovascular disease (congestive heart failure, established ischemic heart disease, peripheral arterial disease) or uncontrolled hypertension. If Diclofenac (Dyrect) treatment is needed, patients with established cardiovascular disease, uncontrolled hypertension or significant cardiovascular risk factors (eg, hypertension, hyperlipidaemia, diabetes mellitus and smoking) should be treated only after careful consideration and at doses ≤100 mg daily if the treatment is for >4 weeks. As the cardiovascular risks of Diclofenac (Dyrect) may increase with dose and duration of exposure, Diclofenac (Dyrect) should always be prescribed at the lowest effective daily dose and for the shortest duration possible.

Renal Impairment: Diclofenac (Dyrect) is contraindicated in patients with renal failure. No specific studies have been carried out in patients with renal impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Diclofenac (Dyrect) to patients with mild to moderate renal impairment.

Hepatic Impairment: Diclofenac (Dyrect) is contraindicated in patients with hepatic failure. No specific studies have been carried out in patients with hepatic impairment, therefore, no specific dose adjustment recommendations can be made. Caution is advised when administering Diclofenac (Dyrect) to patients with mild to moderate hepatic impairment.

Serratiopeptidase (Dyrect) indications

Post-trauma or post-op inflammation. Relief of inflammation due to sinusitis, congestive breast, cystitis, epididymitis, alveolar abscess, parodontitis. Difficulty in expectoration of sputum in resp tract disease & after anesth.

Uses of Serratiopeptidase (Dyrect) in details

Serratiopeptidase (Dyrect) is used in treatment of conditions associated with pain and inflammation associated with muscles, bones and joints, pulsating headaches, often on one side of the head (migraine), inflammation of the air cavities around nose (sinusitis), inflammation of larynx (laryngitis), sore throat, ear infections, swelling after surgery, inflammation of a vein caused by a blood clot (thrombophlebitis), diseases that cause inflammation and sores (ulcer) in the lining of the gut (Ulcerative colitis and Crohn’s disease).

Serratiopeptidase (Dyrect) description

Serrapeptase is a proteolytic enzyme isolated from the micro-organism Serratia E15. This enzyme is naturally processed commercially today through fermentation and was discovered in the silkworm intestine. This immunologically active enzyme is completely bound to the alpha 2 macroglobulin in biological fluids. Serrapeptase digests non-living tissue, blood clots, cysts, and arterial plaque and inflammation in all forms.

Serratiopeptidase (Dyrect) dosage

1 tab tid or as reqd.

Serratiopeptidase (Dyrect) interactions

Anticoagulants.

Serratiopeptidase (Dyrect) side effects

Abnormal blood cell, Blisters on skin, Diarrhoea, Shortness of breath, Nausea, Skin redness, Vomiting, Running nose, Liver damage

Active ingredient matches for Dyrect:

Diclofenac/serratiopeptidase

Diclofenac potassium/serratiopeptidase in India.

Unit description / dosage (Manufacturer)	Price, USD
Dyrect Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. EC-TAB / 50x2	$ 7.59
50x2	$ 7.59
Dyrect 500+10 Tablet	$ 0.08
DYRECT 50 MG/10 MG TABLET 1 packet / 50 tablets each (Ozone Pharmaceuticals Ltd)	$ 4.64
DYRECT 50 MG/10 MG TABLET 1 strip / 10 tablets each (Ozone Pharmaceuticals Ltd)	$ 0.93
DYRECT enteric-coated tab 10's (Ozone Pharma)	$ 0.76
List of Dyrect substitutes (brand and generic names):
DYNAPAR S
ECSEPT D
ECSEPT D TABLET 1 strip / 10 tablets each (Tetramed Biotek Pvt Ltd)	$ 0.78
EDIC-S (India)
EDIC-S tab 10's (Edelweiss)	$ 0.69
ELDISER
ELDISER 50MG/10MG TABLET 1 strip / 10 tablets each (Elder Pharmaceuticals Ltd)	$ 0.61
Eldiser 50 mg/10 mg Tablet (Elder Pharmaceuticals Ltd)	$ 0.06
ENDOSPAZ S
ENDOSPAZ S 50 MG/10 MG TABLET 1 strip / 10 tablets each (Dial Pharmaceuticals Pvt Ltd)	$ 0.57
ENDOZEN K
ENDOZEN-K TABLET
ENDOZEN-K TABLET 1 strip / 10 tablets each (Endocare India)	$ 0.72
ENZOFLAM D
ENZOFLAM D 50 MG/10 MG CAPSULE 1 strip / 10 capsules each (Alkem Laboratories Ltd)	$ 0.87
EPTI-D (India)
EPTI-D tab 10's (Andic)
ESD
ESD TABLET 1 strip / 10 tablets each (Estragen Pharma)	$ 0.67
ESPIDASE D
ESPIDASE D TABLET 1 strip / 10 tablets each (Megha Healthcare Pvt Ltd)	$ 0.64
Eudase-D (India)
100's (Captab)	$ 6.63
Eudase-D Serratiopeptidase 10 mg, diclofenac potassium 50 mg. TAB / 100 (Captab)	$ 6.63
EUDASE-D TABLET 1 strip / 10 tablets each (Captab)	$ 0.66
EUDASE-D tab 10's (Captab)	$ 0.66
EXUDASE D
EXUDASE D 50 MG/10 MG TABLET 1 strip / 10 tablets each (Ravenbhel Pharmaceuticals Pvt Ltd)	$ 0.65
FENASE TABLET
FENASE TABLET 1 strip / 10 tablets each (Lifeline Remedies India Pvt Ltd)	$ 0.66
FENIC-SN (India)
FENIC-SN tab 10's (Shinto Biotec)	$ 0.72
FERADIC
FERADIC 50MG/10MG TABLET 1 strip / 10 tablets each (Cure Quick Pharmaceuticals)	$ 0.71
Feradic 50 mg/10 mg Tablet (Cure Quick Pharmaceuticals)	$ 0.07
FLAMBIT PLUS
FLAMBIT PLUS 50 MG/10 MG TABLET 1 strip / 10 tablets each (Lesanto Laboratories)	$ 0.84
Flanzen D
Flanzen D 50+10 Tablet (Svizera Healthcare (Maneesh Pharmaceuticals Ltd))	$ 0.07
GEOZEN D
GEOZEN D 50MG/10MG TABLET 1 strip / 10 tablets each (Innovative Pharmaceuticals)	$ 0.76
Geozen D 50 mg/10 mg Tablet (Innovative Pharmaceuticals)	$ 0.08
GLASER-PLUS (India)
GLASER-PLUS tab 10's (Gladcare)	$ 0.75
GUFISERAD
GUFISERAD 50MG/10MG TABLET 1 strip / 10 tablets each (Gufic Bioscience Ltd)	$ 0.70
Gufiserad 50 mg/10 mg Tablet (Gufic Bioscience Ltd)	$ 0.07
HEALCROS
HEALCROS 50MG/10MG TABLET 1 strip / 10 tablets each (Ranbaxy Laboratories Ltd)	$ 0.84
INDIAFLAM
INDIAFLAM 50MG/10MG TABLET 1 strip / 15 tablets each (Votary Laboratories I Ltd)	$ 0.81
INDIAFLAM 50MG/10MG TABLET 1 strip / 10 tablets each (Votary Laboratories I Ltd)	$ 0.82
Indiaflam NA Tablet MD (Votary Laboratories I Ltd)	$ 0.02
INFLASER (India)
INFLASER tab 10's (World Wide)	$ 0.77
INSIDER (India)
10's (Skymax Laboratories Pvt.Ltd.)	$ 0.59
Insider Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. TAB / 10 (Skymax Laboratories Pvt.Ltd.)	$ 0.59
Insider 50+10 Tablet (Skymax Laboratories Pvt.Ltd.)	$ 0.05
INSIDER tab 10's (Skymax Laboratories Pvt.Ltd.)	$ 0.59
Insider Diclofenac potassium 50 mg, Serratiopeptidase 10 mg. TAB / 10 (Skymax Laboratories Pvt.Ltd.)	$ 0.59
KINETO-DP (India)
KINETO-DP cap 10's (Systopic)	$ 0.72
Kineto-DP Tablet (Systopic)	$ 0.09
LIPPO
LIPPO 50MG/10MG TABLET 1 strip / 10 tablets each (Monokem Labs)	$ 0.30
Lippo 50 mg/10 mg Tablet (Monokem Labs)	$ 0.03
See 396 substitutes for Dyrect

References

1. DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "diclofenac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "diclofenac". http://www.drugbank.ca/drugs/DB00586 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology