Eclo -P Actions

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Actions of Eclo -P in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Aceclofenac (Eclo -P) is a phenylacetic acid derivative that inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. It increases glycosaminoglycans (GAG) synthesis, the principal macromolecule of the extracellular matrix, which aids in repair and regeneration of articular cartilage. Thus, Aceclofenac (Eclo -P) has +ve effects on cartilage anabolism combined with modulating effect of matrix catabolism. Paracetamol (Eclo -P) has analgesic and antipyretic action with weak anti-inflammatory activity. It produces analgesia by increasing pain threshold and antipyresis by acting on the hypothalamic heat-regulating centre.

Absorption: Aceclofenac (Eclo -P): Rapidly absorbed; almost 100% bioavailability; peak plasma levels reached about 1.25-3 hr after oral admin.

Distribution: Aceclofenac (Eclo -P): >99.7% bound to plasma proteins; distributes into synovial fluid. Paracetamol (Eclo -P): Distributes throughout most fluids of the body.

Metabolism: Aceclofenac (Eclo -P): Probably metabolised by CYP2C9; average plasma elimination half-life: 4-4.3 hr. Paracetamol (Eclo -P): Mainly metabolised hepatically; plasma elimination half-life: 1-4 hr.

Excretion: Aceclofenac (Eclo -P): About two-thirds of the administered dose is removed in the urine, mainly as conjugated hydroxymetabolites. Paracetamol (Eclo -P): Most metabolites are removed in the urine within 24 hr.


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References

  1. EPA DSStox. "Aceclofenac: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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