The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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Contraception And Endometriosis Indications
Route of Administration
Ecogest-M (Ecogest-M acetate) 104 must be given by subcutaneous injection into the anterior thigh or abdomen, once every 3 months (12 to 14 weeks). Ecogest-M (Ecogest-M acetate) 104 is not formulated for intramuscular injection. Dosage does not need to be adjusted for body weight. The pre-filled syringe of Ecogest-M (Ecogest-M acetate) 104 must be vigorously shaken just before use to create a uniform suspension.
First Injection
Ensure that the patient is not pregnant at the time of the first injection. For women who are sexually active and having regular menses, the first injection should be given only during the first 5 days of a normal menstrual period. Women who are breast-feeding may have their first injection during or after their sixth postpartum week.
Second and Subsequent Injections
Dosing is every 12 to 14 weeks. If more than 14 weeks elapse between injections, pregnancy should be ruled out before the next injection.
If Using For Contraception And Switching From Another Method
When switching from other contraceptive methods, Ecogest-M 104 should be given in a manner that ensures continuous contraceptive coverage. For example, patients switching from combined (estrogen plus progestin) contraceptives should have their first injection of Ecogest-M (Ecogest-M acetate) 104 within 7 days after the last day of using that method (7 days after taking the last active pill, removing the patch or ring). Similarly, contraceptive coverage will be maintained in switching from Ecogest-M CI (150 mg) to Ecogest-M (Ecogest-M acetate) 104, provided the next injection is given within the prescribed dosing period for Ecogest-M CI (150 mg).
If Using For Treatment Of Endometriosis
Treatment for longer than two years is not recommended, due to the impact of long-term Ecogest-M (Ecogest-M acetate) 104 on bone mineral density. If symptoms return after discontinuation of treatment, bone mineral density should be evaluated prior to retreatment.
Instructions for Use of Ecogest-M (Ecogest-M acetate) 104
FOR SUBCUTANEOUS ADMINISTRATION ONLY.
Please read these instructions carefully. It is very important that the entire dose of deposubQ provera 104 is given.
Getting ready
Ensure that the medication is at room temperature. Make sure the following components are available.
Ecogest-M (Ecogest-M acetate) 104, as with other parenteral drug products, should be inspected visually for particulate matter and discoloration prior to administration.
Step 1: Choosing & preparing
Choose the injection area.
Avoid boney areas and the umbilicus
The upper thigh & abdomen are preferred injection sites. See shaded areas in diagram
Use an alcohol pad to wipe the skin in the injection area you have chosen.
Allow the skin to dry
Preferred injection areas:
Step 2: Syringe preparation
Carefully remove the needle and syringe from the packaging.
Hold the syringe firmly by the barrel, with the barrel pointing upward.
Shake it forcefully for at least 1 minute to thoroughly mix the medication
Hold the syringe barrel firmly.
Unscrew the protective cap from the tip of the syringe barrel
Hold the syringe barrel firmly.
Attach the needle to the barrel of the syringe by pushing down firmly with a slight twist
Move the safety shield away from the needle and toward the syringe barrel. The safety shield will remain in an open 45 to 90 degree position
While holding the syringe barrel firmly, remove the plastic cover from the needle without twisting, ensuring the needle is still firmly attached to the syringe
While holding the syringe with the needle pointing upward, gently push in the plunger until the medicine is up to the top of the syringe. There should be no air within the barrel
Step 3: Injecting the dose
Gently grasp and squeeze a large area of skin in the chosen injection area between the thumb and forefinger, pulling it away from the body.
Insert the needle at a 45 degree angle so that most of the needle is in the fatty tissue.
The plastic hub of the needle should be nearly or almost touching the skin
Inject the medication slowly until the syringe is empty.
It is important that the entire dose of deposubQ provera 104 is given
This should take about 5–7 seconds
Step 4: Disposing the needle and syringe
After completing the injection, remove the needle from the skin and activate the safety shield.
Position shield about 40°- 45°. With a firm quick motion, press down against a flat surface until a click is heard or felt.
If uncertain that the safety shield is fully engaged, repeat this step.
Use a clean cotton pad to press lightly on the injection area for a few seconds.
Do NOT rub the area
Following the administration of each dose, the used syringe should be discarded in a safe and proper manner.
Keep away from children.
How supplied
Ecogest-M 104 for subcutaneous use (Ecogest-M acetate injectable suspension 104 mg/0.65 mL) is available as a pre-filled syringe, packaged with a 26gauge x 3/8 inch Terumo® Surguard™ needle in the following presentation:
NDC 0009-4709-13 0.65 mL single-use, disposable syringe
Store at controlled room temperature 20°to 25°C (68°to 77°F).
Distributed By: Pharmacia & Upjohn Company, Division of Pfizer Inc, NY, NY 10017. Revised June 2009.
What other drugs will affect Ecogest-M?
Tell your doctor about all your current medicines and any you start or stop using, especially:
bosentan;
griseofulvin;
St. John's wort;
an antibiotic or antifungal medicine;
HIV or AIDS medicine;
seizure medicine; or
sleep medicine (to treat insomnia).
This list is not complete. Other drugs may interact with Ecogest-M, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Ecogest-M interactions
Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Ecogest-M, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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Aminoglutethimide administered concomitantly with Ecogest-M Sterile Aqueous Suspension may significantly depress the serum concentrations of Ecogest-M acetate. Ecogest-M users should be warned of the possibility of decreased efficacy with the use of this or any related drugs.
In vitro
Ecogest-M acetate is metabolized primarily by hydroxylation via the CYP3A4. Though no formal drug interaction trials have been conducted, concomitant administration of strong CYP3A inhibitors is expected to increase concentrations of Ecogest-M acetate, whereas the concomitant administration of strong CYP3A inducers is expected to decrease Ecogest-M acetate concentrations. Therefore, coadministration with strong CYP3A inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole) or strong CYP3A inducers (e.g., phenytoin, carbamazepine, rifampin, rifabutin, rifapentin, phenobarbital, St. John's Wort) should be avoided.
Laboratory Test Interactions
The pathologist should be advised of progestin therapy when relevant specimens are submitted. The following laboratory tests may be affected by progestins including DEPOPROVERA Sterile Aqueous Suspension:
Plasma and urinary steroid levels are decreased (e.g. progesterone, estradiol, pregnanediol, testosterone, cortisol).
Gonadotropin levels are decreased.
Sex-hormone binding globulin concentrations are decreased.
Protein bound iodine and butanol extractable protein bound iodine may increase. T3 uptake values may decrease.
Coagulation test values for prothrombin (Factor II), and Factors VII, VIII, IX, and X may increase.
Sulfobromophthalein and other liver function test values may be increased.
The effects of Ecogest-M acetate on lipid metabolism are inconsistent. Both increases and decreases in total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol have been observed in studies.
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Reviews
The results of a survey conducted on ndrugs.com for Ecogest-M are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Ecogest-M. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
2 consumers reported frequency of use
How frequently do I need to take Ecogest-M? It was reported by ndrugs.com website users that Ecogest-M should ideally be taken Twice in a day as the most common frequency of the Ecogest-M. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Ecogest-M should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
Users
%
Twice in a day
2
100.0%
1 consumer reported doses
What doses of Ecogest-M drug you have used? The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Ecogest-M drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
Users
%
6-10mg
1
100.0%
Consumer reviews
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