Emeliv Uses

How do you administer this medicine?
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What is Emeliv?

Emeliv is used to treat the symptoms of a certain type of stomach problem called gastroparesis in patients with diabetes. It works by increasing the movements or contractions of the stomach and intestines. It relieves symptoms such as nausea, vomiting, heartburn, a feeling of fullness after meals, and loss of appetite. Emeliv is also used to treat heartburn for patients with gastroesophageal reflux disease (GERD). GERD is esophageal irritation from the backward flow of gastric acid into the esophagus.

Emeliv is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Emeliv is used in certain patients with the following medical conditions:

Emeliv indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Emeliv increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.

Emeliv is used short-term to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief of symptoms.

Emeliv is also used to treat slow gastric emptying in people with diabetes (also called diabetic gastroparesis), which can cause nausea, vomiting, heartburn, loss of appetite, and a feeling of fullness after meals.

How should I use Emeliv?

Follow the directions on your prescription label and read all medication guides. Use the medicine exactly as directed.

A Emeliv injection is given into a muscle or as an infusion into a vein. A healthcare provider will give the injection, usually during surgery, chemotherapy, or a medical procedure.

Emeliv oral is taken for only 4 to 12 weeks.

NEVER USE Emeliv IN LARGER AMOUNTS THAN RECOMMENDED, OR FOR LONGER THAN 12 WEEKS. High doses or long-term use of Emeliv can cause a serious movement disorder that may not be reversible. The longer you use Emeliv, the more likely you are to develop this movement disorder. The risk of this side effect is higher in diabetics and older adults (especially women).

Emeliv is usually taken 30 minutes before meals and at bedtime, or only with meals that usually cause heartburn. Follow your doctor's dosing instructions very carefully.

Do not use two different forms of Emeliv (such as tablets and oral syrup) at the same time.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

To take the orally disintegrating tablet (ODT):

Store at room temperature in a tightly-closed container, away from moisture and heat. Keep the bottle tightly closed.

After you stop taking Emeliv, you may have unpleasant withdrawal symptoms such as headache, dizziness, or nervousness.

Uses of Emeliv in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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How to use Emeliv injection

Emeliv description

Each ampoule of injection contains anhydrous Emeliv (as Emeliv) 10 mg in 2 mL and sodium chloride in water for injections. When necessary, pH is adjusted with sodium hydroxide and/or hydrochloric acid.

Emeliv is 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide HCl monohydrate. It has a molecular weight of 354.3 and its molecular formula is C14H22ClN3O2·HCl·H2O.

Emeliv hydrochloride occurs as a white or almost white, crystalline powder or crystals, very soluble in water, freely soluble in alcohol, sparingly soluble in methylene chloride, practically insoluble in ether.

Emeliv dosage

Usual Adult Emeliv Dose for Nausea/Vomiting:

Postoperative nausea and vomiting:

Parenteral: 10 to 20 mg IM at or near the end of surgery

Usual Adult Emeliv Dose for Gastroesophageal Reflux Disease:

Oral: 10 to 15 mg up to 4 times a day 30 minutes before meals and at bedtime, depending upon symptoms being treated and clinical response. Therapy should not exceed 12 weeks.

Usual Adult Emeliv Dose for Small Intestine Intubation:

If the tube has not passed the pylorus with conventional methods in 10 minutes, a single (undiluted) dose may be administered IV slowly over 1 to 2 minutes:

Adults and pediatric patients greater than or equal to 14 years: 10 mg IV as a single dose administered over 1 to 2 minutes.

Usual Adult Emeliv Dose for Radiographic Exam:

Adults and pediatric patients greater than or equal to 14 years: 10 mg IV as a single dose administered over 1 to 2 minutes to facilitate gastric emptying where delayed gastric emptying interferes with radiological examination of the stomach and/or small intestine.

Usual Adult Emeliv Dose for Gastroparesis:

During the earliest manifestations of diabetic gastric stasis, oral administration may be initiated. If severe symptoms are present, therapy should begin with IM or IV administration for up to 10 days until symptoms subside at which time the patient can be switched to oral therapy. Since diabetic gastric stasis is often recurrent, therapy should be reinstituted at the earliest manifestation.

Parenteral: 10 mg 4 times daily, IV (slowly over a 1 to 2 minute period) or IM for up to 10 days.

Oral: 10 mg 4 times daily, 30 minutes before meals and at bedtime, for 2 to 8 weeks depending on clinical response.

Usual Adult Emeliv Dose for Nausea/Vomiting -- Chemotherapy Induced:

IV infusion: 1 to 2 mg/kg/dose (depending on the emetogenic potential of the agent) IV (infused over a period of not less than 15 minutes) 30 minutes before administration of chemotherapy. The dose may be repeated twice at 2 hour intervals following the initial dose. If vomiting is still not suppressed, the same dose may be repeated 3 more times at 3 hour intervals.

For doses higher than 10 mg, the injection should be diluted in 50 mL of a parenteral solution. Normal saline is the preferred diluent.

If acute dystonic reactions occur, 50 mg of diphenhydramine hydrochloride may be injected IM.

Usual Adult Emeliv Dose for Migraine:

Use for treatment of migraine headaches is not an FDA approved indication; however, Emeliv has shown efficacy in studies at a dose of 10 to 20 mg IV once (used in combination with analgesics or ergot derivatives).

Usual Pediatric Emeliv Dose for Gastroesophageal Reflux Disease:

Emeliv is not approved by the FDA for gastroesophageal reflux disease in pediatric patients; however, the following doses have been studied:

Oral, IM, IV:

Infants and Children: 0.4 to 0.8 mg/kg/day in 4 divided doses

Usual Pediatric Emeliv Dose for Small Intestine Intubation:

Emeliv IV is approved by the FDA for pediatric use to facilitate small bowel intubation by causing gastric emptying where delayed gastric emptying interferes with radiological examination of the stomach and/or small intestine.

If the tube has not passed the pylorus with conventional methods in 10 minutes, a single (undiluted) dose may be administered IV slowly over 1 to 2 minutes:

Less than 6 years: 0.1 mg/kg IV as a single dose

6 to 14 years: 2.5 to 5 mg IV as a single dose

Children greater than 14 years: 10 mg as a single dose

Usual Pediatric Emeliv Dose for Nausea/Vomiting -- Chemotherapy Induced:

Emeliv is not approved by the FDA for chemotherapy induced nausea and vomiting in pediatric patients; however, the following doses have been studied:

IV:

1 to 2 mg/kg/dose IV every 30 minutes before chemotherapy and every 2 to 4 hours

Usual Pediatric Emeliv Dose for Nausea/Vomiting -- Postoperative:

Emeliv is not approved by the FDA for postoperative nausea and vomiting in pediatric patients; however, the following doses have been studied:

IV:

Children less than or equal to 14 years: 0.1 to 0.2 mg/kg/dose (maximum dose: 10 mg/dose); repeat every 6 to 8 hours as needed

Children greater than 14 years and Adults: 10 mg; repeat every 6 to 8 hours as needed

Emeliv interactions

See also:
What other drugs will affect Emeliv?

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Before taking Emeliv, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Emeliv.

Tell your doctor about all other medications you use, especially:

acetaminophen (Tylenol);

cyclosporine (Gengraf, Neoral, Sandimmune);

digoxin (digitalis, Lanoxin);

glycopyrrolate (Robinul);

levodopa (Larodopa, Atamet, Parcopa, Sinemet);

mepenzolate (Cantil);

tetracycline (Brodspec, Panmycin, Robitet, Sumycin, Tetracap, and others);

atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);

bladder or urinary medications such as darifenacin (Enablex), tolterodine (Detrol), or solifenacin (Vesicare);

bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);

irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), or propantheline (Pro-Banthine);

an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate); or

medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), haloperidol (Haldol), olanzapine (Zyprexa, Symbyax), prochlorperazine (Compazine), risperidone (Risperdal), thiothixene (Navane), and others.

Emeliv side effects

See also:
What are the possible side effects of Emeliv?

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Get emergency medical help if you have any of these signs of an allergic reaction to Emeliv: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Emeliv and call your doctor at once if you have any of these serious side effects:

tremors, or restless muscle movements in your eyes, tongue, jaw, or neck;

mask-like appearance of the face;

very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;

depressed mood, thoughts of suicide or hurting yourself;

hallucinations, anxiety, agitation, jittery feeling, trouble staying still;

swelling, fluid retention;

jaundice (yellowing of your skin or eyes); or

seizure (convulsions).

Less serious Emeliv side effects may include:

feeling restless, drowsy, tired, or dizzy;

headache, sleep problems (insomnia);

nausea, vomiting, diarrhea;

breast tenderness or swelling;

changes in your menstrual periods; or

urinating more than usual.

Emeliv contraindications

See also:
What is the most important information I should know about Emeliv?

You should not take this medication if you are allergic to Emeliv, or if you have bleeding or blockage in your stomach or intestines, epilepsy or other seizure disorder, or an adrenal gland tumor (pheochromocytoma).

Active ingredient matches for Emeliv:

Metoclopramide HCl in Singapore.


Unit description / dosage (Manufacturer)Price, USD
Emeliv 10 mg x 1000's$ 43.00

List of Emeliv substitutes (brand and generic names):

Briface-OPC 10 mg x 2 Blister x 20 Tablet
DHA Metoclopramide 10 mg x 1000 Tablet
Gingsuwel 5 mg
Metoran 10 mg/2 mL x 10 tube x 2 mL
Nausin 10 mg x 1000's
R-J Tab/Syrup 10 mg x 1, 000's
R-J Tab/Syrup 5 mg/5 mL x 30 mL
R-J Tab/Syrup 5 mg/5 mL x 1 gal
Syntomide 10 mg x 1's
Vincomid 10 mg/2 mL x 12 tube x 2 ml
Vomaine 5 mg/1 mL x 2 mL x 10's
Weiperan 10 mg x 1000's
YSPPulin 10 mg x 10 Blister x 1o Tablet
YSPPulin 10 mg x 1 Bottle 1000 Tablet

References

  1. PubChem. "metoclopramide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "metoclopramide". http://www.drugbank.ca/drugs/DB01233 (accessed September 17, 2018).
  3. MeSH. "Antiemetics". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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