Endofit Dosage

How times a day do you take this medicine?
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Dosage of Endofit in details

The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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1 tab daily without any break, taken preferably at the same time each day with some liquid as needed. Tablets must be taken continuously without regard to vaginal bleeding. When a pack is finished the next one should be started without interruption.

Tablet-taking can be started on any day of the menstrual cycle.

There is no experience with Endofit treatment >15 months in patients with endometriosis.

The efficacy of Endofit may be reduced in the event of missed tablets, vomiting and/or diarrhea (if occurring within 3-4 hrs after tab taking). In the event of missed tablet(s), the woman should take 1 tab only, as soon as she remembers, and should then continue the next day to take the tab at her usual time. A tablet not absorbed due to vomiting or diarrhea should likewise be replaced by 1 tablet.

Renal Impairment: There are no data suggesting the need for a dosage adjustment in patients with renal impairment.

Hepatic Impairment: Endofit is contraindicated in patients with present or past severe hepatic disease.

Administration: For oral use.

Endofit interactions

Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Endofit, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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Effects of Other Drugs on Endofit: Individual Enzyme-Inducers or Inhibitors (CYP3A4): Progestogens including Endofit are metabolized mainly by the cytochrome P-450 3A4 system (CYP3A4), located both in the intestinal mucosa and in the liver. Therefore, inducers or inhibitors of CYP3A4 may affect the progestogen drug metabolism.

An increased clearance of sex hormones due to enzyme induction may reduce the therapeutic effect of Endofit and may result in undesirable effects eg, changes in the uterine bleeding profile.

A reduced clearance of sex hormones due to enzyme inhibition may increase the exposure to Endofit and may result in undesirable effects.

Substances with Enzyme-Inducing Properties: Interactions can occur with drugs (eg, phenytoin, barbiturates, primidone, carbamazepine, rifampicin, and possibly also oxcarbazepine, topiramate, felbamate, griseofulvin, nevirapine and products containing St. John’s wort) that induce microsomal enzymes (eg, cytochrome P-450 enzymes) which can result in increased clearance of sex hormones.

Maximum enzyme induction is generally not seen for 2-3 weeks but may then be sustained for at least 4 weeks after the cessation of therapy.

The effect of the CYP3A4 inducer rifampicin was studied in healthy postmenopausal women. Co-administration of rifampicin with estradiol valerate/Endofit tablets led to significant decreases in steady-state concentrations and systemic exposures of Endofit and estradiol. The systemic exposure of Endofit and estradiol at steady state, measured by AUC (0-24 hrs), were decreased by 83% and 44%, respectively.

Substances with Enzyme-Inhibiting Properties: Known CYP3A4 inhibitors like azole antifungals (eg, ketoconazole, itraconazole, fluconazole), cimetidine, verapamil, macrolides (eg, erythromycin, clarithromycin and roxithromycin), diltiazem, protease inhibitors (eg, ritonavir, saquinavir, indinavir, nelfinavir), antidepressants (eg, nefazodone, fluvoxamine, fluoxetine) and grapefruit juice may increase plasma levels of progestogens and result in undesirable efffects.

In a study investigating the effect of CYP3A4 inhibitors (ketoconazole, erythromycin) on the combination of estradiol valerate/Endofit, steady-state Endofit plasma levels were increased. Co-administration with the strong inhibitor ketoconazole resulted in a 186% increase of AUC (0-24 hrs) at steady state for Endofit. When co-administered with the moderate inhibitor erythromycin, the AUC (0-24 hrs) of Endofit at steady state were increased by 62%.

The clinical relevance of these interactions is unknown.

Effects of Endofit on Other Drugs: Based on in vitro inhibition studies, a clinically relevant interaction of Endofit with the cytochrome P-450 enzyme mediated metabolism of other drugs is unlikely.

Note: The prescribing information of concomitant medication should be consulted to identify potential interactions.

Drug-Food Interactions: A standardized high fat meal did not affect the bioavailability of Endofit.

Other Forms of Interactions: The use of progestogens may influence the results of certain laboratory tests, including biochemical parameters of liver, thyroid, adrenal and renal function, plasma levels of (carrier) proteins (eg, corticosteroid-binding globulin and lipid/lipoprotein fractions), parameters of carbohydrate metabolism and parameters of coagulation and fibrinolysis. Changes generally remain within the normal laboratory range.

Incompatibilities: Not applicable.


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References

  1. DailyMed. "DIENOGEST; ESTRADIOL VALERATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. FDA/SPL Indexing Data. "46M3EV8HHE: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
  3. MeSH. "Hormone Antagonists". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Endofit are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Endofit. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported frequency of use

How frequently do I need to take Endofit?
It was reported by ndrugs.com website users that Endofit should ideally be taken Once in a day as the most common frequency of the Endofit. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Endofit should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
Users%
Once in a day1
100.0%


3 consumers reported doses

What doses of Endofit drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Endofit drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
Users%
1-5mg2
66.7%
11-50mg1
33.3%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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