What happens if I overdose Enzovexx?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately. Enzovexx patch may be harmful if swallowed.
Proper storage of Enzovexx patch:
Store Enzovexx patch at 77 degrees F (25 degrees C) in the sealed pouch. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Throw away any unused patches 3 months after opening the pouch. The pouch is not child-resistant. Keep Enzovexx patch out of the reach of children and away from pets.
Overdose of Enzovexx in details
Symptoms: There is no typical clinical picture resulting from Enzovexx overdosage. Overdosage can cause symptoms such as vomiting, gastrointestinal hemorrhage, diarrhea, dizziness, tinnitus or convulsions. In the event of significant poisoning, acute renal failure and liver damage are possible.
Therapeutic Measures: Management of acute poisoning with NSAIDs, including Enzovexx, essentially consists of supportive measures and symptomatic treatment. Supportive measures and symptomatic treatment should be given for complications such as hypotension, renal failure, convulsions, gastrointestinal disorder, and respiratory depression.
Special measures such as forced diuresis, dialysis, or hemoperfusion are probably of no help in eliminating NSAIDs, including Enzovexx, due to the high protein binding and extensive metabolism.
Activated charcoal may be considered after ingestion of a potentially toxic overdose, and gastric decontamination (e.g. vomiting, gastric lavage) after ingestion of a potentially life-threatening overdose.
Gastro-Resistant/SR Tablets: Activated charcoal may be considered after ingestion of a potentially toxic overdose, and gastric decontamination (e.g. vomiting, gastric lavage) after ingestion of a potentially life-threatening overdose.
What should I avoid while taking Enzovexx?
Ask a doctor or pharmacist before using any cold, allergy, or other pain medicine. Medicines similar to Enzovexx are contained in many combination medicines. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.
Avoid drinking alcohol. It may increase your risk of stomach bleeding.
Avoid exposure to sunlight or tanning beds. Enzovexx can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Enzovexx warnings
Enzovexx should be used cautiously with the elderly. In patients with congestive heart failure, hypertension, decreased renal, or hepatic function, history of gastrointestinal disease or those receiving anticoagulants.
Enzovexx 50 DT is recommended for short-term treatment only.
Use in Pregnancy and Lactation:
Enzovexx should not be used during pregnancy particularly the last three months owing to the possibility of uterine inertia and/or premature closure of the ductus arteriosus.
Enzovexx is excreted in breast milk, but in quantities so small that no undesirable effects on the infant are to be expected.
Management of acute poisoning with NSAIDs consists essentially of supportive and symptomatic measures. There is no typical clinical picture associated with overdosage of Enzovexx.
The following therapeutic measures should be taken in cases of overdosage:
Absorption should be prevented as soon as possible after the overdosage by means of gastric lavage and treatment with activated charcoal.
Supportive and symptomatic treatment should be given for complications such as hypotension, renal failure, convulsions, gastrointestinal irritation and respiratory depression.
Specific therapy such as forced diuresis, dialysis or haemoperfusion is unlikely to be helpful in accelerating the elimination of NSAIDs because of their high protein binding rate and extensive metabolism.
What should I discuss with my healthcare provider before taking Enzovexx?
Enzovexx can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking Enzovexx.
Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Enzovexx may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Enzovexx, especially in older adults.
You should not use Enzovexx if you are allergic to Enzovexx, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.
To make sure Enzovexx is safe for you, tell your doctor if you have:
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heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;
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a history of heart attack, stroke, or blood clot;
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a history of stomach ulcers or bleeding;
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asthma;
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liver or kidney disease;
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fluid retention.
Taking Enzovexx during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether Enzovexx passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Enzovexx is not approved for use by anyone younger than 18 years old.
Enzovexx precautions
Deterioration in renal function has been attributed to the concomitant use of Enzovexx and triamterene and to the concomitant use of Enzovexx and cyclosporin.
Enzovexx sodium has been associated with clinical exacerbation of porphyria and is considered unsafe in porphyric patients.
Use in pregnancy & lactation: In late pregnancy, Enzovexx should, as with other NSAIDs, be avoided because it will cause premature arteriosus. The effect of Enzovexx on labor and delivery in pregnant women are unknown. Because of the known effects of prostaglandin-inhibiting drugs on the fetal cardiovascular system (closure of ductus arteriosus), use of Enzovexx during late pregnancy should be avoided and as with other NSAIDs, it is possible that Enzovexx may inhibit uterine contractions and delay parturition.
Because of the potential of serious adverse reactions in nursing infants from Enzovexx, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
What happens if I miss a dose of Enzovexx?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "diclofenac". http://www.drugbank.ca/drugs/DB00586 (accessed September 17, 2018).
- MeSH. "Cyclooxygenase Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
