Erythromycin Estolate Uses

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Erythromycin Estolate indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Infectious-inflammatory diseases caused by microorganisms sensitive to erythromycin, including diphtheria, pertussis, trachoma, brucellosis, a disease Legionnaires, sore throat, scarlet fever, otitis media, sinusitis, cholecystitis, pneumonia, gonorrhea, syphilis. Also Erythromycin Estolate used for the treatment of infectious-inflammatory diseases caused by pathogens (eg staphylococci) are resistant to penicillin, tetracycline, chloramphenicol, streptomycin.

For external use: acne vulgaris.

For local use: the infectious-inflammatory diseases of eyes.

Erythromycin Estolate dosage

Adults: Usual Dose: 250 mg every 6 hrs. This may be increased up to ≥4 g daily according to the severity of the infection.

Children: Age, weight and severity of the infection are important factors in determining the proper dosage. The usual regimen is 30-50 mg/kg/day in divided doses. For more severe infections, this dosage may be doubled.

If administration is desired on a twice-a-day schedule in either adults or children, ½ of the total daily dose may be given every 12 hrs. Twice-a-day dosing is not recommended with doses >1 g daily are administered.

Streptococcal Infections: For the treatment of streptococcal pharyngitis and tonsillitis, the usual dosage range is 20-50 mg/kg/day in divided doses.

In the treatment of group A β-hemolytic streptococcal infections, a therapeutic dosage of erythromycin should be administered for at least 10 days.

In continuous prophylaxis of streptococcal infections in persons with a history of rheumatic heart disease, the dosage is 250 mg twice a day.

For prophylaxis against bacterial endocarditis in penicillin allergic patients with congenital heart disease, rheumatic or other acquired valvular heart disease when undergoing dental procedures or surgical procedures of the upper respiratory tract. The dosage schedule for adults is 1 g (20 mg/kg for children) orally 1 hr before the procedure and then 500 mg (10 mg/kg for children) orally 6 hrs later.

Primary Syphilis: A regimen of Erythromycin Estolate 20 g in divided doses over a period of 10 days has been shown to be effective in the treatment of primary syphilis.

Dysenteric Amebiasis: Adults: 250 mg 4 times daily for 10-14 days. Children: 30-50 mg/kg/day in divided doses for 10-14 days.

Pertussis: Although optimum dosage and duration of treatment have not been established, dosage of erythromycin utilized in reported clinical studies was 40-50 mg/kg/day, given in divided doses for 5-14 days.

Legionnaire's Disease: Although optimum doses have not been established, doses utilized in reported clinical data were those recommended (1-4 g Erythromycin Estolate daily in divided doses).

Conjunctivitis of the Newborn Caused by C. trachomatis:

Oral erythromycin suspension, 50 mg/kg/day in 4 divided doses for at least 2 weeks.

Pneumonia of Infancy Caused by C. trachomatis: Although the optimum duration of therapy has not been established, the recommended therapy is oral erythromycin suspension, 50 mg/kg/day in 4 divided doses for at least 3 weeks.

Urogenital Infections During Pregnancy Due to C. trachomatis: Although the optimum dose and duration of therapy have not been established, the suggested treatment is erythromycin, 500 mg orally 4 times a day for at least 7 days. For women who cannot tolerate this regimen, a decreased dose of 250 mg orally 4 times a day should be used for at least 14 days.

For adults with uncomplicated urethral, endocervical or rectal infections caused by C. trachomatis in whom tetracyclines are contraindicated or not tolerated, 500 mg orally 4 times a day for at least 7 days.

Erythromycin Estolate interactions

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With simultaneous use of Erythromycin Estolate with theophylline, aminophylline, caffeine, there is an increase in their concentration in blood plasma and thus increases the risk of toxic effects.

Erythromycin increases the concentrations of cyclosporine in the blood plasma and may increase the risk of nephrotoxicity.

Drugs that block tubular secretion prolongs T1/2 of erythromycin.

Incompatible with lincomycin, clindamycin and chloramphenicol (antagonism).

Erythromycin Estolate reduces the bactericidal action of beta-lactam antibiotics (penicillins, cephalosporins, carbapenems).

With simultaneous use of erythromycin increases the concentration of theophylline.

At the same time receiving chemotherapy, which is carried metabolism in the liver (carbamazepine, valproic acid, hexobarbital, phenytoin, alfentanil, dizopiramid, lovastatin, bromocriptine), may increase the concentration of these drugs in plasma (an inhibitor of microsomal liver enzymes).

IV injection of erythromycin increases the effects of ethanol (accelerating gastric emptying and decrease the duration of alcohol dehydrogenase in the gastric mucosa).

Erythromycin reduces the clearance of triazolam and midazolam and therefore may increase the pharmacological effects of benzodiazepines.

At the same time taking with terfenadine or astemizole may develop arrhythmias (fibrillation and ventricular flutter, ventricular tachycardia, until death); with dihydroergotamine or non hydrated ergot alkaloids may vasoconstriction to spasm, dysesthesia.

With simultaneous application Erythromycin Estolate slows elimination (increases the effect) of methylprednisolone, felodipine and anticoagulants of cumarine series.

In a joint appointment with lovastatin increased rhabdomyolysis.

Erythromycin increases the bioavailability of digoxin.

Erythromycin reduces the effectiveness of hormonal contraceptives.

Erythromycin Estolate side effects

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The most frequent side effects of erythromycin preparations are gastrointestinal (eg, abdominal cramping and discomfort) and are dose-related. Nausea, vomiting and diarrhea occur frequently with usual oral doses. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment.

During prolonged or repeated therapy, there is a possibility of overgrowth of nonsusceptible bacteria or fungi. If such infections arise, the drug should be discontinued and appropriate therapy instituted.

Mild allergic reactions eg, urticaria and other skin rashes have occurred. Serious allergic reactions, including anaphylaxis, have been reported.

There have been isolated reports of hearing loss and/or tinnitus in patients receiving erythromycin. The ototoxic effect of the drug is usually reversible with drug discontinuance. However, in rare instances involving IV administration, the ototoxic effect has been irreversible. Ototoxic effects occur chiefly in patients with renal or hepatic insufficiency and in patients receiving high doses of erythromycin.

Very rarely erythromycin has been associated with QT prolongation and ventricular arrhythmias, including ventricular tachycardia and torsade des pointes.

Several reports of infantile hypertrophic pyloric stenosis have been reported in newborn infants receiving various erythromycin products, including Erythromycin Estolate. Erythromycin should be used cautiously in the first 3 months of life.

Erythromycin Estolate contraindications

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Patients with known hypersensitivity to erythromycin. Patients taking terfenadine, astemizole, cisapride, pimozide, verapamil or diltiazem.

Patients with known history of sensitivity to Erythromycin Estolate and for those with preexisting liver disease.

Active ingredient matches for Erythromycin Estolate:

Erythromycin Estolate


Unit description / dosage (Manufacturer)Price, USD
Erythromycin Estolate / P.J. 100 mg/1 g x 1 g
Erythromycin Estolate / Root 250 mg
Erythromycin Estolate / Root 250 mg x Blister pk
Erythromycin Estolate / Astar 250 mg
Erythromycin Estolate / Chi Sheng 250 mg
Erythromycin Estolate / LITA 250 mg
Erythromycin Estolate / H.S.C 100 mg/1 g x 1 g

List of Erythromycin Estolate substitutes (brand and generic names):

Ciresto Dry 30 ml Syrup (Oboi Laboratories (Ciron Drugs & Pharmaceuticals Pvt Ltd))$ 0.04
Citamycin P 125 mg Tablet (Citadel Fine Pharma (P) Ltd.)$ 0.03
CITAMYCIN P TABLET 1 strip / 10 tablets each (Citadel Fine Pharma (P) Ltd.)$ 0.30
Citamycin P NA Tablet (Citadel Fine Pharma (P) Ltd.)$ 0.03
250 mg x 10's (Bactolac)$ 0.46
125 mg x 5 mL x 60ml (Bactolac)$ 0.39
125 mg x 10's (Bactolac)$ 0.10
Erocyn 250mg TAB / 10 (Bactolac)$ 0.46
Erocyn 125mg x 5mL LIQD / 60ml (Bactolac)$ 0.39
Erocyn 125mg JR-TAB / 10 (Bactolac)$ 0.10
EROCYN tab 250 mg x 10's (Bactolac)$ 0.46
EROCYN oral liqd 125 mg x 5 mL x 60ml (Bactolac)$ 0.39
EROCYN P- tab 125 mg x 10's (Bactolac)$ 0.10
Erocyn 250mg TAB / 10 (Bactolac)$ 0.46
Erocyn 125mg x 5mL LIQD / 60ml (Bactolac)$ 0.39
Erocyn 125mg JR-TAB / 10 (Bactolac)$ 0.10
250 mg x 200's
Eroma 250mg TAB / 200
Eroma 250mg TAB / 200
Eryo Dry Syrup 125 mg/5 mL x 60 mL (Vesco Pharma)
Eryo Dry Syrup dry syr 125 mg/5 mL 60 mL x 1's (Vesco Pharma)
Erythromycin E 250 mg x 1000's
Ilosone oral drops 100 mg/mL 10 mL x 1's (Aspen)$ 4.61
Ilosone DS oral susp 250 mg/5 mL 60 mL x 1's (Aspen)$ 9.44
Ilosone oral susp 125 mg/5 mL 60 mL x 1's (Aspen)$ 6.47
Suprith 30 ml Suspension (Neon Laboratories Ltd)$ 0.07
T Mycin Kid 125 mg Tablet (Hamax Pharmaceuticals)$ 0.02
Throt 250 mg Tablet (Mamta Pharmaceuticals)$ 0.07
Throt Kid 125 mg Tablet (Mamta Pharmaceuticals)$ 0.03
Trithrocin 250 mg Tablet (Trio Remedies Pvt.Ltd)$ 0.07
Walosone 25 mg/1 mL x 1 mL
Walosone 25 mg/1 mL x 30 mL
Walosone 25 mg/1 mL x 60 mL

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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