Etodolac Uses

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What is Etodolac?

Etodolac (Etodolac) is a nonsteroidal anti-inflammatory drug (NSAID). Etodolac works by reducing hormones that cause inflammation and pain in the body.

Etodolac is used to treat mild to moderate pain, osteoarthritis, or rheumatoid arthritis.

Etodolac may also be used for purposes not listed in this medication guide.

Etodolac indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Carefully consider the potential benefits and risks of Etodolac Extended-Release Tablets and other treatment options before deciding to use Etodolac Extended-Release Tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

Etodolac Extended-Release Tablets are indicated:

*
For relief of signs and symptoms of juvenile arthritis
*
For relief of the signs and symptoms of rheumatoid arthritis
*
For relief of the signs and symptoms of osteoarthritis

How should I use Etodolac?

Use Etodolac extended-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about the proper use of Etodolac extended-release tablets.

Uses of Etodolac in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Etodolac is used to relieve painful conditions of the bone, joints and soft tissues such as inflammatory arthritis (rheumatoid arthritis) and advanced osteoarthritis.

Etodolac description

Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.

Etodolac dosage

Etodolac Dosage

Generic name: Etodolac

Dosage form: Capsules and Tablets

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Carefully consider the potential benefits and risks of Etodolac and other treatment options before deciding to use Etodolac. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

After observing the response to initial therapy with Etodolac, the dose and frequency should be adjusted to suit an individual patient's needs. As with other NSAIDs, the lowest dose and longest dosing interval should be sought for each patient. Therefore, after observing the response to initial therapy with Etodolac, the dose and frequency should be adjusted to suit an individual patient's needs.

Dosage adjustment of Etodolac is generally not required in patients with mild to moderate renal impairment. Etodolac should be used with caution in such patients, because, as with other NSAIDs, it may further decrease renal function in some patients with impaired renal function.

Analgesia

The recommended total daily dose of Etodolac for acute pain is up to 1000 mg, given as 200-400 mg every 6 to 8 hours. Doses of Etodolac greater than 1000 mg/day have not been adequately evaluated in well-controlled clinical trials.

Osteoarthritis and Rheumatoid Arthritis

The recommended starting dose of Etodolac for the management of the signs and symptoms of osteoarthritis or rheumatoid arthritis is: 300 mg b.i.d., t.i.d., or 400 mg b.i.d., or 500 mg b.i.d. A lower dose of 600 mg/day may suffice for long-term administration. Physicians should be aware that doses above 1000 mg/day have not been adequately evaluated in well-controlled clinical trials.

In chronic conditions, a therapeutic response to therapy with Etodolac is sometimes seen within one week of therapy, but most often is observed by two weeks. After a satisfactory response has been achieved, the patient's dose should be reviewed and adjusted as required.

More about Etodolac (Etodolac)

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Other formulations

Related treatment guides

Etodolac interactions

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What other drugs will affect Etodolac?

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Drug Interactions ACE-inhibitors

Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.

Antacids

The concomitant administration of antacids has no apparent effect on the extent of absorption of Etodolac. However, antacids can decrease the peak concentration reached by 15% to 20% but have no detectable effect on the time-to-peak.

Aspirin

When Etodolac is administered with aspirin, its protein binding is reduced, although the clearance of free Etodolac is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of Etodolac and aspirin is not generally recommended because of the potential of increased adverse effects.

Cyclosporine, Digoxin, Methotrexate

Etodolac, like other NSAIDs, through effects on renal prostaglandins, may cause changes in the elimination of these drugs leading to elevated serum levels of cyclosporine, digoxin, methotrexate, and increase toxicity. Nephrotoxicity associated with cyclosporine may also be enhanced. Patients receiving these drugs who are given Etodolac, or any other NSAID, and particularly those patients with altered renal function, should be observed for the development of the specific toxicities of these drugs. NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.

Diuretics

Etodolac has no apparent pharmacokinetic interaction when administered with furosemide or hydrochlorothiazide. Nevertheless, clinical studies, as well as post marketing observations have shown that Etodolac can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for sings of renal failure, as well as to assure diuretic efficacy.

Glyburide

Etodolac has no apparent pharmacokinetic interaction when administered with glyburide.

Lithium

NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. The mean minimum lithium concentration increased 15% and the renal clearance was decreased by approximately 20%. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.

Phenylbutazone

Phenylbutazone causes increase (by about 80%) in the free fraction of Etodolac. Although in vivo studies have not been done to see if Etodolac clearance is changed by coadministration of phylbutazone, it is not recommended that they be coadministered.

Phenytoin

Etodolac has no apparent pharmacokinetic interaction when administered with phenytoin.

Warfarin

The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than that of users of either drug alone. Short-term pharmacokinetic studies have demonstrated that concomitant administration of warfarin and Etodolac results in reduced protein binding of warfarin, but there was no change in the clearance of free warfarin. There was no significant difference in the pharmacodynamic effect of warfarin administered alone and warfarin administered with Etodolac as measured by prothrombin time. Thus, concomitant therapy with warfarin and Etodolac should not require dosage adjustment of either drug. However, caution should be exercised because there have been a few spontaneous reports of prolonged prothrombin times, with or without bleeding, in Etodolac-treated patients receiving concomitant warfarin therapy.

Drug/Laboratory Test Interactions

The urine of patients who take Etodolac can give a false-positive reaction for urinary bilirubin (urobilin) due to the presence of phenolic metabolites of Etodolac. Diagnostic dip-stick methodology, used to detect ketone bodies in urine, has resulted in false-positive findings in some patients treated with Etodolac. Generally, this phenomenon has not been associated with other clinically significant events. No dose relationship has been observed.

Etodolac treatment is associated with a small decrease in serum uric acid levels. In clinical trials, mean decreases of 1 to 2 mg/dL were observed in arthritic patients receiving Etodolac (600 mg to 1000 mg/day) after 4 weeks of therapy. These levels then remained stable for up to 1 year of therapy.

Etodolac side effects

See also:
What are the possible side effects of Etodolac?

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A total of 1552 patients were exposed to Etodolac Extended-Release Tablets in controlled clinical studies of at least 4 weeks in length and using daily doses in the range of 400 to 1200 mg. In the tabulations below, adverse event rates are generally categorized based on the incidence of events in the first 30 days of treatment with Etodolac Extended-Release Tablets. As with other NSAIDs, the cumulative adverse event rates may increase significantly over time with extended therapy.

In patients taking NSAIDs, including Etodolac Extended-Release Tablets, the most frequently reported adverse experiences occurring in approximately 1 to 10% of patients are: gastrointestinal experiences including:

*
Adverse events that were observed in < 1% of patients in the first 30 days of treatment with Etodolac Extended-Release Tablets in clinical trials.
abdominal pain constipation diarrhea
dyspepsia flatulence GI ulcers (gastric/duodenal)*
gross bleeding/perforation* nausea vomiting
other events including:
abnormal renal function* anemia* asthenia
dizziness edema* elevated liver enzymes*
headaches hypertension increased bleeding time*
infection pharyngitis pruritus
rashes rhinitis tinnitus*

Additional NSAID Adverse Experiences Reported Occasionally with NSAIDs or Etodolac Extended-Release Tablets Include

Body as a whole - allergic reaction, anaphylactic/anaphylactoid reactions (including shock), chills, fever, sepsis

Cardiovascular system - congestive heart failure, flushing, palpitations, tachycardia, syncope, vasculitis (including necrotizing and allergic)

Digestive system - anorexia, cholestatic hepatitis, cholestatic jaundice, dry mouth, duodenitis, eructation, esophagitis, gastritis, gastric/peptic ulcers, glossitis, hepatic failure, hepatitis, hematemesis, intestinal ulceration, jaundice, liver necrosis, melena, pancreatitis, rectal bleeding, stomatitis

Hemic and lymphatic system - agranulocytosis, ecchymosis, eosinophilia, hemolytic anemia, leukopenia, neutropenia, pancytopenia, purpura, thrombocytopenia

Metabolic and nutritional - hyperglycemia in previously controlled diabetic patients

Nervous system - anxiety, confusion, depression, dream abnormalities, insomnia, nervousness, paresthesia, somnolence, tremors, vertigo

Respiratory system - asthma, dyspnea, pulmonary infiltration with eosinophilia

Skin and appendages - angioedema, cutaneous vasculitis with purpura, erythema multiforme, hyperpigmentation, sweating, urticaria, vesiculobullous rash

Special senses - blurred vision, photophobia, transient visual disturbances

Urogenital system - dysuria, elevated BUN, oliguria/polyuria, proteinuria, renal failure, renal insufficiency, renal papillary necrosis, serum creatinine increase, urinary frequency

Other NSAID Adverse Reactions, Which Occur Rarely Are

Body as a whole - anaphylactic reactions, appetite changes, death

Cardiovascular system - arrhythmia, cerebrovascular accident, hypotension, myocardial infarction

Digestive system - colitis, esophagitis with or without stricture or cardiospasm, thirst, ulcerative stomatitis

Hemic and lymphatic system - aplastic anemia, lymphadenopathy

Metabolic and nutritional - change in weight

Nervous system - coma, convulsions, hallucinations, meningitis

Respiratory - bronchitis, pneumonia, respiratory depression, sinusitis

Skin and appendages - alopecia, exfoliative dermatitis, maculopapular rash, photosensitivity, skin peeling, Stevens-Johnson syndrome, toxic epidermal necrosis

Special senses - conjunctivitis, deafness, hearing impairment, taste perversion

Urogenital system - cystitis, hematuria, interstitial nephritis, leukorrhea, renal calculus, uterine bleeding irregularities

Etodolac contraindications

See also:
What is the most important information I should know about Etodolac?

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use Etodolac. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking Etodolac. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to Etodolac (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.

Do not drink alcohol while taking Etodolac. Alcohol can increase the risk of stomach bleeding caused by Etodolac.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Etodolac can make your skin more sensitive to sunlight and sunburn may result.



Active ingredient matches for Etodolac:

Etodolac


Unit description / dosage (Manufacturer)Price, USD
Tablet; Oral; Etodolac 400 mg
Capsule; Oral; Etodolac 200 mg
Capsule; Oral; Etodolac 300 mg
Tablet; Oral; Etodolac 500 mg
Tablet, Extended Release; Oral; Etodolac 400 mg
Tablet, Extended Release; Oral; Etodolac 500 mg
Tablet, Extended Release; Oral; Etodolac 600 mg
Tablet; Oral; Etodolac400 mg
Etodolac CR 600 mg 24 Hour tablet$ 2.76
Lodine 400 mg tablet$ 2.65
Lodine 500 mg tablet$ 1.80
Etodolac CR 500 mg 24 Hour tablet$ 1.60
Etodolac 500 mg tablet$ 1.52
Etodolac 400 mg tablet$ 1.50
Etodolac CR 400 mg 24 Hour tablet$ 1.46
Etodolac 300 mg capsule$ 1.31
Apo-Etodolac 200 mg Capsule$ 0.80
Apo-Etodolac 300 mg Capsule$ 0.80
Etodolac / Sinphar 200 mg
Etodolac / Center 200 mg
Etodolac capsule 200 mg (Aa Pharma Inc (Canada))
Etodolac capsule 300 mg (Aa Pharma Inc (Canada))
Etodolac capsule 300 mg/1 (Pd Rx Pharmaceuticals, Inc. (US))
Etodolac tablet, film coated, extended release 600 mg/1 (Zydus Pharmaceuticals (USA, US) Inc.)
Etodolac tablet 400 mg/1 (DIRECT RX (US))
Etodolac tablet, coated 400 mg/1 (Eon Labs, Inc. (US))
Etodolac tablet, film coated 400 mg/1 (STAT Rx USA LLC (US))
Etodolac tablet, film coated, extended release 400 mg/1 (Dispensing Solutions, Inc. (US))
Etodolac tablet, film coated 500 mg/1 (Teva Pharmaceuticals Usa, Inc. (US))
Etodolac tablet, extended release 400 mg/1 (bryant ranch prepack (US))
Etodolac tablet, extended release 600 mg/1 (Northstar Rx LLC (US))
Etodolac capsule 200 mg/1 (KAISER FOUNDATION HOSPITALS (US))
Etodolac tablet 500 mg/1 (DIRECT RX (US))
Etodolac tablet, coated 500 mg/1 (Eon Labs, Inc. (US))
Etodolac tablet, extended release 500 mg/1 (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC (US))
Etodolac capsule, gelatin coated 300 mg/1 (Rebel Distributors Corp (US))
Etodolac tablet, film coated, extended release 500 mg/1 (Unit Dose Services (US))

List of Etodolac substitutes (brand and generic names):

Etodon 200 mg x 10's (Shinlon)
Etodon 200 mg x 500's (Shinlon)
400 mg x 10's (Medico HC)$ 2.37
Etofact 400mg TAB / 10 (Medico HC)$ 2.37
ETOFACT tab 400 mg x 10's (Medico HC)$ 2.37
Etofact 400mg TAB / 10 (Medico HC)$ 2.37

References

  1. DailyMed. "ETODOLAC: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "etodolac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "etodolac". http://www.drugbank.ca/drugs/DB00749 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Etodolac are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Etodolac. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


Consumer reported price estimates

No survey data has been collected yet


2 consumers reported time for results

To what extent do I have to use Etodolac before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 month and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Etodolac. To get the time effectiveness of using Etodolac drug by other patients, please click here.
Users%
1 month1
50.0%
1 day1
50.0%


2 consumers reported age

Users%
> 602
100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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