Exodolan Uses

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What is Exodolan?

Exodolan (Exodolan) is a nonsteroidal anti-inflammatory drug (NSAID). Exodolan works by reducing hormones that cause inflammation and pain in the body.

Exodolan is used to treat mild to moderate pain, osteoarthritis, or rheumatoid arthritis.

Exodolan may also be used for purposes not listed in this medication guide.

Exodolan indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Carefully consider the potential benefits and risks of Exodolan Extended-Release Tablets and other treatment options before deciding to use Exodolan Extended-Release Tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

Exodolan Extended-Release Tablets are indicated:

*
For relief of signs and symptoms of juvenile arthritis
*
For relief of the signs and symptoms of rheumatoid arthritis
*
For relief of the signs and symptoms of osteoarthritis

How should I use Exodolan?

Use Exodolan extended-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about the proper use of Exodolan extended-release tablets.

Uses of Exodolan in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Exodolan is used to relieve painful conditions of the bone, joints and soft tissues such as inflammatory arthritis (rheumatoid arthritis) and advanced osteoarthritis.

Exodolan description

Exodolan is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.

Exodolan dosage

Exodolan Dosage

Generic name: Exodolan

Dosage form: Capsules and Tablets

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Carefully consider the potential benefits and risks of Exodolan and other treatment options before deciding to use Exodolan. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

After observing the response to initial therapy with Exodolan, the dose and frequency should be adjusted to suit an individual patient's needs. As with other NSAIDs, the lowest dose and longest dosing interval should be sought for each patient. Therefore, after observing the response to initial therapy with Exodolan, the dose and frequency should be adjusted to suit an individual patient's needs.

Dosage adjustment of Exodolan is generally not required in patients with mild to moderate renal impairment. Exodolan should be used with caution in such patients, because, as with other NSAIDs, it may further decrease renal function in some patients with impaired renal function.

Analgesia

The recommended total daily dose of Exodolan for acute pain is up to 1000 mg, given as 200-400 mg every 6 to 8 hours. Doses of Exodolan greater than 1000 mg/day have not been adequately evaluated in well-controlled clinical trials.

Osteoarthritis and Rheumatoid Arthritis

The recommended starting dose of Exodolan for the management of the signs and symptoms of osteoarthritis or rheumatoid arthritis is: 300 mg b.i.d., t.i.d., or 400 mg b.i.d., or 500 mg b.i.d. A lower dose of 600 mg/day may suffice for long-term administration. Physicians should be aware that doses above 1000 mg/day have not been adequately evaluated in well-controlled clinical trials.

In chronic conditions, a therapeutic response to therapy with Exodolan is sometimes seen within one week of therapy, but most often is observed by two weeks. After a satisfactory response has been achieved, the patient's dose should be reviewed and adjusted as required.

More about Exodolan (Exodolan)

Consumer resources

Professional resources

Other formulations

Related treatment guides

Exodolan interactions

See also:
What other drugs will affect Exodolan?

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Drug Interactions ACE-inhibitors

Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.

Antacids

The concomitant administration of antacids has no apparent effect on the extent of absorption of Exodolan. However, antacids can decrease the peak concentration reached by 15% to 20% but have no detectable effect on the time-to-peak.

Aspirin

When Exodolan is administered with aspirin, its protein binding is reduced, although the clearance of free Exodolan is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of Exodolan and aspirin is not generally recommended because of the potential of increased adverse effects.

Cyclosporine, Digoxin, Methotrexate

Exodolan, like other NSAIDs, through effects on renal prostaglandins, may cause changes in the elimination of these drugs leading to elevated serum levels of cyclosporine, digoxin, methotrexate, and increase toxicity. Nephrotoxicity associated with cyclosporine may also be enhanced. Patients receiving these drugs who are given Exodolan, or any other NSAID, and particularly those patients with altered renal function, should be observed for the development of the specific toxicities of these drugs. NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.

Diuretics

Exodolan has no apparent pharmacokinetic interaction when administered with furosemide or hydrochlorothiazide. Nevertheless, clinical studies, as well as post marketing observations have shown that Exodolan can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for sings of renal failure, as well as to assure diuretic efficacy.

Glyburide

Exodolan has no apparent pharmacokinetic interaction when administered with glyburide.

Lithium

NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. The mean minimum lithium concentration increased 15% and the renal clearance was decreased by approximately 20%. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.

Phenylbutazone

Phenylbutazone causes increase (by about 80%) in the free fraction of Exodolan. Although in vivo studies have not been done to see if Exodolan clearance is changed by coadministration of phylbutazone, it is not recommended that they be coadministered.

Phenytoin

Exodolan has no apparent pharmacokinetic interaction when administered with phenytoin.

Warfarin

The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than that of users of either drug alone. Short-term pharmacokinetic studies have demonstrated that concomitant administration of warfarin and Exodolan results in reduced protein binding of warfarin, but there was no change in the clearance of free warfarin. There was no significant difference in the pharmacodynamic effect of warfarin administered alone and warfarin administered with Exodolan as measured by prothrombin time. Thus, concomitant therapy with warfarin and Exodolan should not require dosage adjustment of either drug. However, caution should be exercised because there have been a few spontaneous reports of prolonged prothrombin times, with or without bleeding, in Exodolan-treated patients receiving concomitant warfarin therapy.

Drug/Laboratory Test Interactions

The urine of patients who take Exodolan can give a false-positive reaction for urinary bilirubin (urobilin) due to the presence of phenolic metabolites of Exodolan. Diagnostic dip-stick methodology, used to detect ketone bodies in urine, has resulted in false-positive findings in some patients treated with Exodolan. Generally, this phenomenon has not been associated with other clinically significant events. No dose relationship has been observed.

Exodolan treatment is associated with a small decrease in serum uric acid levels. In clinical trials, mean decreases of 1 to 2 mg/dL were observed in arthritic patients receiving Exodolan (600 mg to 1000 mg/day) after 4 weeks of therapy. These levels then remained stable for up to 1 year of therapy.

Exodolan side effects

See also:
What are the possible side effects of Exodolan?

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A total of 1552 patients were exposed to Exodolan Extended-Release Tablets in controlled clinical studies of at least 4 weeks in length and using daily doses in the range of 400 to 1200 mg. In the tabulations below, adverse event rates are generally categorized based on the incidence of events in the first 30 days of treatment with Exodolan Extended-Release Tablets. As with other NSAIDs, the cumulative adverse event rates may increase significantly over time with extended therapy.

In patients taking NSAIDs, including Exodolan Extended-Release Tablets, the most frequently reported adverse experiences occurring in approximately 1 to 10% of patients are: gastrointestinal experiences including:

*
Adverse events that were observed in < 1% of patients in the first 30 days of treatment with Exodolan Extended-Release Tablets in clinical trials.
abdominal pain constipation diarrhea
dyspepsia flatulence GI ulcers (gastric/duodenal)*
gross bleeding/perforation* nausea vomiting
other events including:
abnormal renal function* anemia* asthenia
dizziness edema* elevated liver enzymes*
headaches hypertension increased bleeding time*
infection pharyngitis pruritus
rashes rhinitis tinnitus*

Additional NSAID Adverse Experiences Reported Occasionally with NSAIDs or Exodolan Extended-Release Tablets Include

Body as a whole - allergic reaction, anaphylactic/anaphylactoid reactions (including shock), chills, fever, sepsis

Cardiovascular system - congestive heart failure, flushing, palpitations, tachycardia, syncope, vasculitis (including necrotizing and allergic)

Digestive system - anorexia, cholestatic hepatitis, cholestatic jaundice, dry mouth, duodenitis, eructation, esophagitis, gastritis, gastric/peptic ulcers, glossitis, hepatic failure, hepatitis, hematemesis, intestinal ulceration, jaundice, liver necrosis, melena, pancreatitis, rectal bleeding, stomatitis

Hemic and lymphatic system - agranulocytosis, ecchymosis, eosinophilia, hemolytic anemia, leukopenia, neutropenia, pancytopenia, purpura, thrombocytopenia

Metabolic and nutritional - hyperglycemia in previously controlled diabetic patients

Nervous system - anxiety, confusion, depression, dream abnormalities, insomnia, nervousness, paresthesia, somnolence, tremors, vertigo

Respiratory system - asthma, dyspnea, pulmonary infiltration with eosinophilia

Skin and appendages - angioedema, cutaneous vasculitis with purpura, erythema multiforme, hyperpigmentation, sweating, urticaria, vesiculobullous rash

Special senses - blurred vision, photophobia, transient visual disturbances

Urogenital system - dysuria, elevated BUN, oliguria/polyuria, proteinuria, renal failure, renal insufficiency, renal papillary necrosis, serum creatinine increase, urinary frequency

Other NSAID Adverse Reactions, Which Occur Rarely Are

Body as a whole - anaphylactic reactions, appetite changes, death

Cardiovascular system - arrhythmia, cerebrovascular accident, hypotension, myocardial infarction

Digestive system - colitis, esophagitis with or without stricture or cardiospasm, thirst, ulcerative stomatitis

Hemic and lymphatic system - aplastic anemia, lymphadenopathy

Metabolic and nutritional - change in weight

Nervous system - coma, convulsions, hallucinations, meningitis

Respiratory - bronchitis, pneumonia, respiratory depression, sinusitis

Skin and appendages - alopecia, exfoliative dermatitis, maculopapular rash, photosensitivity, skin peeling, Stevens-Johnson syndrome, toxic epidermal necrosis

Special senses - conjunctivitis, deafness, hearing impairment, taste perversion

Urogenital system - cystitis, hematuria, interstitial nephritis, leukorrhea, renal calculus, uterine bleeding irregularities

Exodolan contraindications

See also:
What is the most important information I should know about Exodolan?

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use Exodolan. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking Exodolan. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to Exodolan (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.

Do not drink alcohol while taking Exodolan. Alcohol can increase the risk of stomach bleeding caused by Exodolan.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Exodolan can make your skin more sensitive to sunlight and sunburn may result.



Active ingredient matches for Exodolan:

Etodolac in Portugal.


List of Exodolan substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Etura 500mg TAB / 10 (Dr. Reddy's)
Febret 200 mg x 5 Blister x 10 Tablet (Ranbaxy)
Febret 400 mg x 5 Blister x 10 Tablet (Ranbaxy)
FREEUP ER 600MG TABLET 1 strip / 10 tablets each (Sanofi India Ltd)$ 1.73
Freeup 600mg Tablet ER (Sanofi India Ltd)$ 0.17
Freeup ER 600 mg Tablet (Universal Medicare Ltd.)$ 0.17
Capsule; Oral; Etodolac 200 mg
Capsule; Oral; Etodolac 300 mg
Higesic-P Etodolac 400 mg, paracetamol500 mg. TAB / 10 (Olcare)$ 1.59
HIGESIC-P tab 10's (Olcare)$ 1.59
Jenac 200 mg x 20's
Jenac 200 mg x 1000's
Kosmin 200 mg x 10 Blister x 10 Tablet
Lacoxa 400 mg x 1000's
LACOXA 100MG TABLET 1 strip / 10 tablets each (Abbott India Ltd)$ 1.37
LACOXA 200MG TABLET 1 strip / 10 tablets each (Abbott India Ltd)$ 2.41
LACOXA 50MG TABLET 1 strip / 10 tablets each (Abbott India Ltd)$ 0.78
Lacoxa 100mg Tablet (Abbott India Ltd)$ 0.15
Lacoxa 10mg Injection (Abbott India Ltd)$ 0.14
Lacoxa 200mg Tablet (Abbott India Ltd)$ 0.27
Lacoxa 50mg Tablet (Abbott India Ltd)$ 0.09
600 mg x 10's (Lexus)
Letodo 600mg ER-TAB / 10 (Lexus)
LETODO ER tab 600 mg x 10's (Lexus)
Letodo 600mg ER-TAB / 10 (Lexus)
Capsule; Oral; Etodolac 200 mg (Algol)
Capsule; Oral; Etodolac 300 mg (Algol)
Tablet, Film-Coated; Oral; Etodolac 200 mg (Algol)
Tablet, Film-Coated; Oral; Etodolac 300 mg (Algol)
Tablet; Oral; Etodolac 400 mg (Algol)
Tablet; Oral; Etodolac 500 mg (Algol)
Lodine capsule, gelatin coated 300 mg/1 (Algol)
Lodine tablet, film coated 400 mg/1 (Algol)
Tablet, Retard; Oral; Etodolac 400 mg
Tablet, Retard; Oral; Etodolac 600 mg
Tablet, Sustained Release; Oral; Etodolac 600 mg
Tablet, Extended Release; Oral; Etodolac 400 mg (Wyeth)

References

  1. DailyMed. "ETODOLAC: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "etodolac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "etodolac". http://www.drugbank.ca/drugs/DB00749 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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