Actions of Farlutal Depot in details
Pharmacotherapeutic Group: Progestogens. ATC Code: L02AB.
Pharmacology: Farlutal Depot has the pharmacological action of a progestogen.
Pharmacokinetics: Farlutal Depot is absorbed from the gastrointestinal tract with a single oral dose of 10-250 mg. The time taken to reach the peak serum concentration (Tmax) was 2-6 hrs and the average peak serum concentration (Cmax) was 13-46.89 mg/mL.
Unmetabolised Farlutal Depot is highly plasma protein bound.
Farlutal Depot is metabolised in the liver.
Farlutal Depot is primarily metabolised by fecal excretion as glucoronide conjugated metabolite.
Metabolised Farlutal Depot is excreted more rapidly and in a greater percentage following oral doses than after aqueous IM injection.
Toxicology: Preclinical Safety Data: No further preclinical safety data available.
How should I take Farlutal Depot?
A nurse or other trained health professional will give you Farlutal Depot in a hospital or clinic. Farlutal Depot is given as a shot into one of your muscles (usually in the buttocks or upper arm).
If you are using Farlutal Depot®: Farlutal Depot is initially given on a weekly basis, but the frequency may be less often over time.
If you are using Farlutal Depot CI® (contraceptive injection):
- To make using hormonal contraceptives as safe and reliable as possible, you should understand how and when to use them and what effects may be expected.
- Farlutal Depot comes with patient information insert. Read them carefully and make sure you understand them before receiving Farlutal Depot. If you have any questions, ask your doctor.
- Your doctor must make sure you are not pregnant before you start treatment with Farlutal Depot. For most women, this means you must receive your first shot during the first 5 days of a normal menstrual period. You will need to receive Farlutal Depot every 3 months (12 to 14 weeks). Be sure to keep all appointments with your doctor to receive your injections.
- If you plan to start Farlutal Depot after having a baby, you should receive your first shot within 5 days after your baby is born. If you plan to breastfeed your new baby, talk to your doctor about when to get your first shot. Some doctors may suggest waiting 6 weeks before getting your first shot, but others may suggest getting the shot sooner after the baby is born. If you wait 6 weeks, talk to your doctor about using an alternative form of birth control.
- If you are switching from another method of birth control, carefully follow your doctor’s instructions about when to have your first injection of Farlutal Depot.
- You need to have enough calcium and vitamin D in your diet. Your doctor might suggest that you take supplements.
Missed Dose
Call your doctor or pharmacist for instructions.
You must have your shot of Farlutal Depot CI® (contraceptive injection) every 12 to 14 weeks to prevent pregnancy. If you do not get another shot after 14 weeks, talk with your doctor. You may need to use another form of birth control and wait until your next menstrual period before starting the shots again.
Farlutal Depot administration
Farlutal Depot is injected into a muscle or under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.
Farlutal Depot may be given once per week or once every 3 months, depending on why you are using the medication. Follow your doctor's instructions.
Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.
You may have breakthrough bleeding while using Farlutal Depot. Tell your doctor if this bleeding continues or is very heavy.
This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Farlutal Depot.
Your doctor will need to see you on a regular basis while you are using this medication. Do not miss any appointments.
Store at room temperature away from moisture and heat.
Farlutal Depot pharmacology
Mechanism of Action
Farlutal Depot CI (Farlutal Depot [MPA]), when administered at the recommended dose to women every 3 months, inhibits the secretion of gonadotropins which, in turn, prevents follicular maturation and ovulation and results in endometrial thinning. These actions produce its contraceptive effect.
Pharmacodynamics
No specific pharmacodynamic studies were conducted with Farlutal Depot CI.
Pharmacokinetics
Absorption
Following a single 150 mg IM dose of Farlutal Depot CI in eight women between the ages of 28 and 36 years old, Farlutal Depot concentrations, measured by an extracted radioimmunoassay procedure, increase for approximately 3 weeks to reach peak plasma concentrations of 1 to 7 ng/mL.
Distribution
Plasma protein binding of MPA averages 86%. MPA binding occurs primarily to serum albumin. No binding of MPA occurs with sex-hormone-binding globulin (SHBG).
Metabolism
MPA is extensively metabolized in the liver by P450 enzymes. Its metabolism primarily involves ring A and/or side-chain reduction, loss of the acetyl group, hydroxylation in the 2-, 6-, and 21-positions or a combination of these positions, resulting in more than 10 metabolites.
Excretion
The concentrations of Farlutal Depot decrease exponentially until they become undetectable (<100 pg/mL) between 120 to 200 days following injection. Using an unextracted radioimmunoassay procedure for the assay of Farlutal Depot in serum, the apparent half-life for Farlutal Depot following IM administration of Farlutal Depot CI is approximately 50 days. Most Farlutal Depot metabolites are excreted in the urine as glucuronide conjugates with only minor amounts excreted as sulfates.
Specific Populations
The effect of hepatic and/or renal impairment on the pharmacokinetics of Farlutal Depot CI is unknown.
References
- DailyMed. "MEDROXYPROGESTERONE ACETATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- NCIt. "Medroxyprogesterone Acetate: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Medroxyprogesterone acetate: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Farlutal Depot are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Farlutal Depot. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported administration
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Information checked by Dr. Sachin Kumar, MD Pharmacology
