Fenofibrate Uses

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What is Fenofibrate?

Fenofibrate (Fenofibrate) helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries).

Fenofibrate is used to treat high cholesterol and high triglyceride levels.

Fenofibrate may also be used for purposes not listed in this medication guide.

Fenofibrate indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Treatment of Severe Hypertriglyceridemia

Fenofibrate is indicated as adjunctive therapy to diet to reduce ​triglycerides (TG) in patients with severe hypertriglyceridemia. Improving glycemic control in diabetic patients showing fasting chylomicronemia will usually obviate the need for pharmacological intervention. Markedly elevated levels of serum triglycerides (e.g. > 2,000 mg/dL) may increase the risk of developing pancreatitis. The effect of Fenofibrate therapy on reducing this risk has not been adequately studied.

Treatment of Primary Hypercholesterolemia or Mixed Dyslipidemia

Fenofibrate is indicated as adjunctive therapy to diet to reduce elevated low-density lipoprotein cholesterol (LDL-C), total cholesterol (Total-C), triglycerides (TG), and apolipoprotein B (Apo B), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hypercholesterolemia or mixed dyslipidemia.

Limitations of Use

​ Fenofibrate at a dose equivalent to 135 mg of Fenofibrate did not reduce coronary heart disease morbidity and mortality in 2 large, randomized controlled trials of patients with type 2 diabetes mellitus.

General Considerations for Treatment

Laboratory studies should be performed to establish that lipid levels are abnormal before instituting Fenofibrate therapy.

Every reasonable attempt should be made to control serum lipids with non-drug methods including appropriate diet, exercise, weight loss in obese patients, and control of any medical problems such as diabetes mellitus and hypothyroidism that may be contributing to the lipid abnormalities. Medications known to exacerbate hypertriglyceridemia (beta-blockers, thiazides, estrogens) should be discontinued or changed if possible, and excessive alcohol intake should be addressed before triglyceride-lowering drug therapy is considered. If the decision is made to use lipid-altering drugs, the patient should be instructed that this does not reduce the importance of adhering to diet.

Drug therapy is not indicated for patients who have elevations of chylomicrons and plasma triglycerides, but who have normal levels of VLDL.

How should I use Fenofibrate?

Use Fenofibrate capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Some brands of Fenofibrate capsules should be taken with food. Some brands may be taken with or without food. Ask your pharmacist if you should take your brand of Fenofibrate capsules with food.
  • Swallow Fenofibrate capsules whole. Do not open, crush, dissolve, or chew before swallowing. If you cannot swallow Fenofibrate capsules whole, tell your doctor. You may need a different medicine.
  • Take Fenofibrate capsules with a full glass of water (8 oz [240 mL]).
  • If you also take a bile acid-binding resin (eg, cholestyramine), do not take it within 4 to 6 hours before or 1 hour after taking Fenofibrate capsules. Check with your doctor if you have any questions.
  • Take Fenofibrate capsules on a regular schedule to get the most benefit from it.
  • Taking Fenofibrate capsules at the same time each day will help you remember to take it.
  • Continue to take Fenofibrate capsules even if you feel well. Do not miss any doses.
  • If you miss a dose of Fenofibrate capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Fenofibrate capsules.

Uses of Fenofibrate in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Hypercholesterolemia or mixed dyslipidemia: Adjunctive therapy to diet for the reduction of low-density lipoprotein cholesterol (LDL-C), total cholesterol (total-C), triglycerides, and apolipoprotein B (apo B), and to increase high-density lipoprotein cholesterol (HDL-C) in adults with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson types IIa and IIb). Use lipid-altering agents in addition to a diet restricted in saturated fat and cholesterol when response to diet and nonpharmacological interventions alone has been inadequate.

Note: While FDA-approved for hypercholesterolemia, Fenofibrate is not a first- or second-line choice; other agents may be more suitable (ACC/AHA [Stone 2013]). In addition, use is not recommended to lower LDL-C or raise HDL-C in the absence of hypertriglyceridemia.

Hypertriglyceridemia: Adjunctive therapy to diet for treatment of adult patients with severe hypertriglyceridemia (Fredrickson types IV and V hyperlipidemia).

Off Label Uses

Primary biliary cholangitis

Data from a single-center, retrospective cohort study support the use of Fenofibrate (in combination with ursodiol) in patients with primary biliary cholangitis (PBC) who have had an incomplete biochemical response to ursodiol monotherapy and showed significant improvement in alkaline phosphatase, a reduction in hepatic decompensation, and transplant-free survival improvement.

Fenofibrate description

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Each film-coated tablet contains Fenofibrate BP 160 mg. It also contains the following excipients: Pregelatinized starch maize, povidone, sodium lauryl sulphate, microcrystalline cellulose, crospovidone, anhydrous colloidal silica, sodium stearyl fumarate, purified water and opadry AMB OY-B-28920.

Fenofibrate is a lipid-regulating agent. The empirical formula is C20H21O4Cl and the molecular weight is 360.83. Fenofibrate is 2-[4-(4-chlorobenzoyl) phenoxy]-2-methyl-propanoic acid, 1-methylethyl ester.

Fenofibrate dosage

General Considerations

Patients should be placed on an appropriate lipid-lowering diet before receiving Fenofibrate, and should continue this diet during treatment with Fenofibrate. Fenofibrate capsules can be given without regard to meals.

Patients should be advised to swallow Fenofibrate capsules whole. Do not open, crush, dissolve or chew capsules.

The initial treatment for dyslipidemia is dietary therapy specific for the type of lipoprotein abnormality. Excess body weight and excess alcoholic intake may be important factors in hypertriglyceridemia and should be addressed prior to any drug therapy. Physical exercise can be an important ancillary measure. Diseases contributory to hyperlipidemia, such as hypothyroidism or diabetes mellitus should be looked for and adequately treated. Estrogen therapy, thiazide diuretics and beta-blockers, are sometimes associated with massive rises in plasma triglycerides, especially in subjects with familial hypertriglyceridemia. In such cases, discontinuation of the specific etiologic agent may obviate the need for specific drug therapy of hypertriglyceridemia.

Lipid levels should be monitored periodically and consideration should be given to reducing the dosage of Fenofibrate if lipid levels fall significantly below the targeted range.

Therapy should be withdrawn in patients who do not have an adequate response after two months of treatment with the maximum recommended dose of 90 mg once daily.

Primary Hypercholesterolemia And Mixed Dyslipidemia

The initial dose of Fenofibrate is 90 mg per day.

Severe Hypertriglyceridemia

The initial dose is 30 to 90 mg per day. Dosage should be individualized according to patient response, and should be adjusted if necessary following repeat lipid determinations at 4 to 8 week intervals. The maximum dose is 90 mg per day.

Impaired Renal Function

Treatment with Fenofibrate should be initiated at a dose of 30 mg per day in patients having mild to moderately impaired renal function, and increased only after evaluation of the effects on renal function and lipid levels at this dose. The use of Fenofibrate should be avoided in patients with severe renal impairment.

Geriatric Patients

Dose selection for the elderly should be made on the basis of renal function.

How supplied

Dosage Forms And Strengths

  • Fenofibrate®(Fenofibrate) capsules, 30 mg are size '4' capsules with opaque light green cap and opaque light green body, imprinted with LUPIN logo and “Fenofibrate” in black ink on body, and “30” in black ink on cap, containing white to off-white pellets.
  • Fenofibrate®(Fenofibrate) capsules, 90 mg are size '3' capsules with opaque dark green cap and opaque white body, imprinted with LUPIN logo and “Fenofibrate” in black ink on body, and “90” in black ink on cap, containing white to off-white pellets.

Storage And Handling

Fenofibrate® (Fenofibrate) Capsules, 30 mg are size '4' capsules with opaque light green cap and opaque light green body, imprinted with LUPIN logo and “Fenofibrate” in black ink on body, and “30” in black ink on cap, containing white to off-white pellets.

NDC 27437 -107 -06 30's Bottle

Fenofibrate® (Fenofibrate) Capsules, 90 mg are size '3' capsules with opaque dark green cap and opaque white body, imprinted with LUPIN logo and “Fenofibrate” in black ink on body, and “90” in black ink on cap, containing white to off-white pellets.

NDC 27437 -108 -06 30's Bottle

NDC 27437 -108 -09 90's Bottle

NDC 27437 -108 -01 100's Bottle

Storage

Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) in a tightly closed container.

Manufactured for: Lupin Pharma, Baltimore, Maryland 21202 United States. Manufactured by: Lupin Limited, Goa -403 722 INDIA OR Lupin Limited, Pithampur (M.P.) -454 775 INDIA. Address Medical Inquiries to: Lupin Pharma Medical Inquiries, 111 South Calvert Street, 21Floor Baltimore, MD 21202 or Call: 1-800-399-2561. Revised: August 2015

Fenofibrate interactions

See also:
What other drugs will affect Fenofibrate?

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Anticoagulants: Fenofibrate enhances oral anticoagulant effect and may increase risk of bleeding. Therefore, this combination is not recommended.

Potentiation of coumarin-type anticoagulant effects has been observed with prolongation of the PT/INR.

Caution should be exercised when coumarin anticoagulants are given in conjunction with Fenofibrate. The dosage of the anticoagulants should be reduced to maintain the PT/INR at the desired level to prevent bleeding complications. Frequent PT/INR determinations are advisable until it has been definitely determined that the PT/INR has stabilized.

Hydroxy methylglutaryl coenzyme A (HMG-CoA) Reductase Inhibitors (Statins): The combined use of Fenofibrate and HMG-CoA reductase inhibitors should be avoided unless the benefit of further alterations in lipid levels is likely to outweigh the increased risk of this drug combination.

The risk of serious muscle toxicity is increased if Fenofibrate is used concomitantly with HMG-CoA reductase inhibitors or other fibrates. Such combination therapy should be used with caution and patients monitored closely for signs of muscle toxicity.

Bile Acid Resins: Since bile acid sequestrants may bind other drugs given concurrently, patients should take Fenofibrate at least 1 hr before or 4-6 hrs after a bile acid binding resin to avoid impeding its absorption.

Immunosuppressants: Immunosuppressants eg, cyclosporine and tacrolimus can produce nephrotoxicity with decreases in CrCl and rises in serum creatinine, and because renal excretion is the primary elimination route of fibrate drugs including Fenofibrate, there is a risk that an interaction will lead to deterioration. The benefits and risks of using Fenofibrate with immunosuppressants and other potentially nephrotoxic agents should be carefully considered and the lowest effective dose employed and renal function monitored.

Some severe cases of reversible renal function impairment have been reported during concomitant administration of Fenofibrate and cyclosporine. The renal function of these patients must therefore be closely monitored and the treatment with Fenofibrate stopped in the case of severe alteration of laboratory parameters.

Cytochrome P450 (CYP450) Enzymes: In vitro studies using human liver microsomes indicate that Fenofibrate and fenofibric acid are not inhibitors of CYP450 isoforms CYP3A4, CYP2D6, CYP2E1 or CYP1A2. They are weak inhibitors of CYP2C19 and CYP2A6 and mild to moderate inhibitors of CYP2C9 at therapeutic concentrations. Patients co-administered Fenofibrate and CYP2C19, CYP2A6 and especially CYP2C9 metabolised drugs with a narrow therapeutic index should be carefully monitored and if necessary, dose adjustment of these drugs is recommended.

Fenofibrate side effects

See also:
What are the possible side effects of Fenofibrate?

Clinical Trials Experience

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.

Fenofibric acid is the active metabolite of Fenofibrate. Adverse events reported by 2% or more of patients treated with Fenofibrate and greater than placebo during double-blind, placebocontrolled trials are listed in Table 1. Adverse events led to discontinuation of treatment in 5.0% of patients treated with Fenofibrate and in 3.0% treated with placebo. Increases in liver tests were the most frequent events, causing discontinuation of Fenofibrate treatment in 1.6% of patients in double-blind trials.

Table 1: Adverse Events Reported by 2% or More of Patients Treated with Fenofibrate and Greater than Placebo During the Double-Blind, Placebo-Controlled Trials

BODY SYSTEM Adverse Event Fenofibrate*

(N = 439)

Placebo

(N = 365)

BODY AS A WHOLE
Abdominal Pain 4.6% 4.4%
Back Pain 3.4% 2.5%
Headache 3.2% 2.7%
DIGESTIVE
Nausea 2.3% 1.9%
Constipation 2.1% 1.4%
INVESTIGATIONS
Abnormal Liver Tests 7.5% 1.4%
Increased AST 3.4% 0.5%
Increased ALT 3.0% 1.6%
Increased Creatine Phosphokinase 3.0% 1.4%
RESPIRATORY
Respiratory Disorder 6.2% 5.5%
Rhinitis 2.3% 1.1%
* Dosage equivalent to 135 mg Fenofibrate

Clinical trials with Fenofibrate did not include a placebo-control arm. However, the adverse event profile of Fenofibrate was generally consistent with that of Fenofibrate. The following adverse events not listed above were reported in ≥ 3% of patients taking Fenofibrate alone:

Gastrointestinal Disorders: Diarrhea, dyspepsia

General Disorders and Administration Site Conditions: Pain

Infections and Infestations: Nasopharyngitis, sinusitis, upper respiratory tract infection

Musculoskeletal and Connective Tissue Disorders: Arthralgia, myalgia, pain in extremity

Nervous System Disorders: Dizzinesss

Postmarketing Experience

The following adverse events have been identified during postapproval use of Fenofibrate: rhabdomyolysis, pancreatitis, renal failure, muscle spasms, acute renal failure, hepatitis, cirrhosis, anemia, asthenia, and severely depressed HDL-cholesterol levels.

Because these events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Fenofibrate contraindications

See also:
What is the most important information I should know about Fenofibrate?

Hypersensitivity to Fenofibrate or to any of the excipients of Fenofibrate NT 145 mg, Fenofibrate Supra 160 mg and Fenofibrate 67M.

Patients with hepatic insufficiency (including biliary cirrhosis, and unexplained persistent liver function abnormality) and renal insufficiency.

Known photoallergy or phototoxic reaction during treatment with fibrates or ketoprofen, chronic or acute pancreatitis with the exception of acute pancreatitis due to severe hypertriglyceridemia, gallbladder disease and severe chronic kidney disease.

Fenofibrate NT 145 mg/Fenofibrate Supra 160 mg: It should not be taken by patients allergic to peanut or arachis oil or soya/soybean lecithin or related products due to the risk of hypersensitivity reactions.

Use in pregnancy: Fenofibrate NT 145 mg/Fenofibrate 67M: There are no adequate data from the use of Fenofibrate in pregnant woman. Animal studies have not demonstrated and teratogenic effects. Embryotoxic effects have been shown at doses in the range of maternal toxicity. The potential risk for humans is unknown. Therefore, film-coated tablet should only be used during pregnancy after a careful benefit/risk assessment.

Fenofibrate Supra 160 mg is contraindicated during pregnancy, in the absence of data. If unexpected pregnancy occurs while taking Fenofibrate, treatment should be interrupted and consult a doctor.

Use in lactation: It is unknown whether Fenofibrate is excreted in human milk. A risk to the newborns/infants cannot be excluded. Fenofibrate Supra 160 mg is contraindicated during breastfeeding in the absence of data. Therefore, Fenofibrate should not be used during breastfeeding in nursing mother.

Use in children: Fenofibrate 67M: The safety and efficacy of Fenofibrate in children have not yet been established. Only limited pediatric data are available. Therefore, the use of Fenofibrate is not recommended in pediatric subjects <18 years.



Active ingredient matches for Fenofibrate:

Fenofibrate


Unit description / dosage (Manufacturer)Price, USD
Capsule; Oral; Fenofibrate 100 mg
Capsule; Oral; Fenofibrate 200 mg
Capsule; Oral; Fenofibrate 300 mg
Capsule; Oral; Fenofibrate 67 mg
Tablet, Film-Coated; Oral; Fenofibrate 160 mg
Tablet; Oral; Fenofibrate 160 mg
Tablet; Oral; Fenofibrate 200 mg
Tablet; Oral; Fenofibrate 67 mg
Tablet; Oral; Fenofibrate 120 mg
Tablet; Oral; Fenofibrate 40 mg
Tablet; Oral; Fenofibrate 100 mg
Tablet; Oral; Fenofibrate 300 mg
Tablet; Oral; Fenofibrate 54 mg
Tablet; Oral; Fenofibrate 107 mg
Triglide 160 mg tablet$ 6.39
Fenoglide 120 mg tablet$ 5.17
Antara 130 mg capsule$ 5.13
Tricor 145 mg tablet$ 4.69
Lipofen 150 mg capsule$ 3.55
Lofibra 200 mg capsule$ 3.25
Lofibra 160 mg tablet$ 3.11
Fenofibrate Micronized 200 mg capsule$ 2.77
Fenofibrate 160 mg$ 2.47
Fenofibrate 160 mg tablet$ 2.38
Lofibra 134 mg capsule$ 2.03
Antara 43 mg capsule$ 1.80
Fenofibrate Micronized 134 mg capsule$ 1.79
Fenoglide 40 mg tablet$ 1.72
Tricor 48 mg tablet$ 1.63
Triglide 50 mg tablet$ 1.49
Lipidil Supra 160 mg Tablet$ 1.40
Lofibra 67 mg capsule$ 1.26
Lipidil Micro 200 mg Capsule$ 1.23
Lipidil Supra 100 mg Tablet$ 1.22
Apo-Feno-Micro 200 mg Capsule$ 1.14
Fenofibrate Micro 200 mg Capsule$ 1.14
Mylan-Fenofibrate Micro 200 mg Capsule$ 1.14
Novo-Fenofibrate Micronized 200 mg Capsule$ 1.14
Pms-Fenofibrate Micro 200 mg Capsule$ 1.14
Ratio-Fenofibrate Mc 200 mg Capsule$ 1.14
Fenofibrate Micronized 67 mg capsule$ 1.00
Lofibra 54 mg tablet$ 0.99
Fenofibrate 54 mg tablet$ 0.81
Apo-Feno-Super 160 mg Tablet$ 0.79
Novo-Fenofibrate-S 160 mg Tablet$ 0.79
Sandoz Fenofibrate S 160 mg Tablet$ 0.79
Apo-Feno-Super 100 mg Tablet$ 0.68
Novo-Fenofibrate-S 100 mg Tablet$ 0.68
Sandoz Fenofibrate S 100 mg Tablet$ 0.68
Apo-Fenofibrate 100 mg Capsule$ 0.64
Apo-Feno-Micro 67 mg Capsule$ 0.45
Novo-Fenofibrate Micronized 67 mg Capsule$ 0.45
Fenofibrate 100 mg x 1000's
Fenofibrate tablet 48 mg/1 (Teva Pharmaceuticals USA Inc (US))
Fenofibrate tablet 145 mg/301 (Northwind Pharmaceuticals (US))
Fenofibrate capsule 150 mg/1 (ANI Pharmaceuticals, Inc. (US))
Fenofibrate tablet 145 mg/1 (Zydus Pharmaceuticals USA Inc (US))
Fenofibrate tablet 40 mg/1 (Global Pharmaceuticals, Division of Impax Laboratories Inc. (US))
Fenofibrate tablet 120 mg/1 (Oceanside Pharmaceuticals (US))
Fenofibrate capsule 43 mg/1 (Lupin Pharmaceuticals, Inc. (US))
Fenofibrate capsule 50 mg/1 (H2 Pharma, Llc (US))
Fenofibrate capsule 130 mg/1 (Lupin Pharmaceuticals, Inc. (US))
Fenofibrate tablet, film coated 145 mg/1 (Camber Pharmaceuticals, Inc. (US))
Fenofibrate tablet 160 mg/1 (Unit Dose Services (US))
Fenofibrate tablet, film coated 160 mg/1 (Mylan Pharmaceuticals Inc. (US))
Fenofibrate capsule 134 mg/1 (American Health Packaging (US))
Fenofibrate capsule 67 mg/1 (Impax Generics (US))
Fenofibrate capsule 200 mg/1 (Ncs Health Care Of Ky, Inc Dba Vangard Labs (US))
Fenofibrate tablet, coated 54 mg/1 (Karalex Pharma LLC (US))
Fenofibrate tablet, coated 145 mg/1 (Aurobindo Pharma Limited (US))
Fenofibrate tablet 160 mg/301 (Northwind Pharmaceuticals (US))
Fenofibrate tablet, film coated 54 mg/1 (Proficient Rx LP (US))
Fenofibrate tablet 54 mg/1 (KAISER FOUNDATION HOSPITALS (US))
Fenofibrate tablet, coated 160 mg/1 (Karalex Pharma LLC (US))
Fenofibrate tablet, film coated 48 mg/1 (Mylan Pharmaceuticals Inc. (US))
Fenofibrate tablet, coated 48 mg/1 (Aurobindo Pharma Limited (US))

List of Fenofibrate substitutes (brand and generic names):

Fenofibrate DOMESCO 100 mg x 3 Blister x 10 Tablet
Fenofibrate DOMESCO 100 mg x 10 Blister x 10 Tablet
Fenofibrate DOMESCO 200 mg x 3 Blister x 10 Tablet
Fenofibrate Ethypharm 200 mg
Fenofibrate GPO FC tab 160 mg 3 x 10's (GPO)
Capsule; Oral; Fenofibrate 134 mg
Capsule; Oral; Fenofibrate 200 mg
Capsule; Oral; Fenofibrate 67 mg

References

  1. DailyMed. "FENOFIBRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "fenofibrate". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "fenofibrate". http://www.drugbank.ca/drugs/DB01039 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Fenofibrate are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Fenofibrate. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported useful

Was the Fenofibrate drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Useful1
100.0%


Consumer reported price estimates

No survey data has been collected yet


Consumer reported time for results

No survey data has been collected yet


2 consumers reported age

Users%
> 602
100.0%


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