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Fertifol 0.4mg Pregnancy |
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Fertifol 0.4mg has been assigned to pregnancy category A by the FDA. During pregnancy, Fertifol 0.4mg is usually used for the treatment of megaloblastic anemia. Fertifol 0.4mg requirements are increased during pregnancy, and deficiency may result in fetal harm. Studies involving pregnant women have failed to reveal evidence that Fertifol 0.4mg increases the risk of fetal abnormalities if administered during pregnancy. Fertifol 0.4mg should only be used during pregnancy if clearly needed.
The recommended daily allowance of Fertifol 0.4mg during pregnancy is 400 to 800 mcg/day. Some experts recommend daily doses of 1 mg for twin pregnancies. The Centers of Disease Control (CDC) in the US have recommended 4 mg/day of Fertifol 0.4mg at least 4 weeks BEFORE conception through the first 3 months of pregnancy for women who have had an infant or fetus with a neural tube defect and 400 mcg/day for all women of childbearing age. Interestingly, neonates with normal serum folate concentrations have been born to folate-deficient mothers. It appears that the fetus can extract folate from maternal plasma, convert folate to a form that is not available for reverse transfer, and use it for its own advantage. Dietary Fertifol 0.4mg is available from green leaves, such as asparagus, broccoli, spinach, and lettuce--each of which contains greater than 1 mg Fertifol 0.4mg per 100 grams dry weight. Excessive cooking can remove or destroy the food content of folate.
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In one study, lactating mothers were given 1 mg of Fertifol 0.4mg per day. There were significant correlations between the maternal and infant plasma and RBC folate concentrations. The average maternal plasma Fertifol 0.4mg concentration was 5.9 ng/mL, which correlated with an average milk Fertifol 0.4mg level of 141.4 ng/mL and an average infant plasma Fertifol 0.4mg concentration of 29 ng/mL. The calculated total intake of Fertifol 0.4mg by nursing infants was 14 to 25 mcg/kg/day. Colostrum is relatively low in folate, but milk folate increases as lactation proceeds. Folate levels in breast-fed infants are significantly higher than in the mothers.
Fertifol 0.4mg is actively excreted into human milk. No adverse effects in nursing infants have been associated with the use of Fertifol 0.4mg during lactation. Fertifol 0.4mg is considered compatible with breast-feeding by the American Academy of Pediatrics. The recommended maternal daily allowance of Fertifol 0.4mg during lactation is 500 mcg. Supplementation is not typically needed in mothers with good nutritional habits.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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