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Fertogen-F Pregnancy |
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Fertogen-F has been assigned to pregnancy category A by the FDA. During pregnancy, Fertogen-F is usually used for the treatment of megaloblastic anemia. Fertogen-F requirements are increased during pregnancy, and deficiency may result in fetal harm. Studies involving pregnant women have failed to reveal evidence that Fertogen-F increases the risk of fetal abnormalities if administered during pregnancy. Fertogen-F should only be used during pregnancy if clearly needed.
The recommended daily allowance of Fertogen-F during pregnancy is 400 to 800 mcg/day. Some experts recommend daily doses of 1 mg for twin pregnancies. The Centers of Disease Control (CDC) in the US have recommended 4 mg/day of Fertogen-F at least 4 weeks BEFORE conception through the first 3 months of pregnancy for women who have had an infant or fetus with a neural tube defect and 400 mcg/day for all women of childbearing age. Interestingly, neonates with normal serum folate concentrations have been born to folate-deficient mothers. It appears that the fetus can extract folate from maternal plasma, convert folate to a form that is not available for reverse transfer, and use it for its own advantage. Dietary Fertogen-F is available from green leaves, such as asparagus, broccoli, spinach, and lettuce--each of which contains greater than 1 mg Fertogen-F per 100 grams dry weight. Excessive cooking can remove or destroy the food content of folate.
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In one study, lactating mothers were given 1 mg of Fertogen-F per day. There were significant correlations between the maternal and infant plasma and RBC folate concentrations. The average maternal plasma Fertogen-F concentration was 5.9 ng/mL, which correlated with an average milk Fertogen-F level of 141.4 ng/mL and an average infant plasma Fertogen-F concentration of 29 ng/mL. The calculated total intake of Fertogen-F by nursing infants was 14 to 25 mcg/kg/day. Colostrum is relatively low in folate, but milk folate increases as lactation proceeds. Folate levels in breast-fed infants are significantly higher than in the mothers.
Fertogen-F is actively excreted into human milk. No adverse effects in nursing infants have been associated with the use of Fertogen-F during lactation. Fertogen-F is considered compatible with breast-feeding by the American Academy of Pediatrics. The recommended maternal daily allowance of Fertogen-F during lactation is 500 mcg. Supplementation is not typically needed in mothers with good nutritional habits.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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