Finagrip Actions

How do you administer this medicine?
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Consists of Chlorphenamine, Ibuprofen, Pseudoephedrine

Actions of Chlorphenamine (Finagrip) in details

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Chlorphenamine (Finagrip) Citadel Fine Pharmaceuticals is a broad-spectrum antimicrobial drug of fluoroquinolone group with bactericidal action. Inhibits DNA gyrase and inhibits the synthesis of bacterial DNA. Highly active against most gram-negative bacteria: Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, Shigella spp., Salmonella spp., Neisseria meningitidis, Neisseria gonorrhoeae.

Chlorphenamine (Finagrip) Citadel Fine Pharmaceuticals is active against Staphylococcus spp. (including strains producing and not producing penicillinase, methicillin-resistant strains), some strains of Enterococcus spp., Campylobacter spp., Legionella spp., Mycoplasma spp., Chlamydia spp., Mycobacterium spp.

ciprofloxacin is active against bacteria producing beta-lactamases.

Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides resistant to ciprofloxacin. The effect on Treponema pallidum is studied not enough.

Chlorphenamine (Finagrip) administration

May be taken with or without food.

Chlorphenamine (Finagrip) pharmacology

Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. Chlorphenamine (Finagrip) is cell cycle phase-nonspecific.

Actions of Ibuprofen (Finagrip) in details

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Pharmacology: Pharmacodynamics: Ibuprofen (Finagrip) is a propionic acid derivative with analgesic, anti-inflammatory and antipyretic activity. Ibuprofen (Finagrip) therapeutic effects are thought to result from its inhibitory effect on the enzyme cyclooxygenase, which results in a marked reduction in prostaglandin synthesis.

Experimental data suggest that Ibuprofen (Finagrip) may competitively inhibit the effect of low-dose aspirin on platelet aggregation when they are dosed concomitantly. Some pharmacodynamics studies show that when single doses of Ibuprofen (Finagrip) 400 mg was taken within 8 hrs before or within 30 min after immediate release aspirin dosing (81 mg), a decreased effect of acetylsalicylic acid/aspirin on the formation of thromboxane or platelet aggregation occurred. Although there are uncertainties regarding extrapolation of these data to the clinical situation, the possibility that regular, long-term use of Ibuprofen (Finagrip) may reduce the cardioprotective effect of low-dose acetylsalicylic acid cannot be excluded. No clinically relevant effect is considered to be likely for occasional Ibuprofen (Finagrip) use.

Pharmacokinetics: Ibuprofen (Finagrip): Ibuprofen (Finagrip) is rapidly absorbed from the gastrointestinal tract, peak serum concentrations occurring 1-2 hrs after administration.

Ibuprofen (Finagrip): The elimination half-life (t½) of Ibuprofen (Finagrip) is approximately 2 hrs. Ibuprofen (Finagrip) is metabolised in the liver to 2 inactive metabolites and these, together with unchanged Ibuprofen (Finagrip), are excreted by the kidney either as such or as conjugates. Excretion by the kidney is both rapid and complete. Ibuprofen (Finagrip) is extensively bound to plasma proteins.

How should I take Ibuprofen (Finagrip)?

Use Ibuprofen (Finagrip) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

Do not take more than your recommended dose. An Ibuprofen (Finagrip) overdose can damage your stomach or intestines. The maximum amount of Ibuprofen (Finagrip) for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount of Ibuprofen (Finagrip) needed to get relief from your pain, swelling, or fever.

A child's dose of Ibuprofen (Finagrip) is based on the age and weight of the child. Carefully follow the dosing instructions provided with children's Ibuprofen (Finagrip) for the age and weight of your child. Ask a doctor or pharmacist if you have questions.

Take Ibuprofen (Finagrip) with food or milk to lessen stomach upset.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

The Ibuprofen (Finagrip) chewable tablet must be chewed before you swallow it.

If you use this medicine long-term, you may need frequent medical tests.

Store at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Ibuprofen (Finagrip) administration

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Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Do not take more of this medication than is recommended. An overdose of Ibuprofen (Finagrip) can cause damage to your stomach or intestines. The maximum amount of Ibuprofen (Finagrip) for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount of Ibuprofen (Finagrip) needed to get relief from your pain, swelling, or fever.

Take Ibuprofen (Finagrip) with food or milk to lessen stomach upset.

Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

The Ibuprofen (Finagrip) chewable tablet must be chewed before you swallow it.

If you take Ibuprofen (Finagrip) for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.

Store at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

Ibuprofen (Finagrip) pharmacology

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Ibuprofen (Finagrip) tablets contain Ibuprofen (Finagrip) which possesses analgesic and antipyretic activities. Its mode of action, like that of other NSAIDs, is not completely understood, but may be related to prostaglandin synthetase inhibition.

In clinical studies in patients with rheumatoid arthritis and osteoarthritis, Ibuprofen (Finagrip) tablets have been shown to be comparable to aspirin in controlling pain and inflammation and to be associated with a statistically significant reduction in the milder gastrointestinal side effects. Ibuprofen (Finagrip) tablets may be well tolerated in some patients who have had gastrointestinal side effects with aspirin, but these patients when treated with Ibuprofen (Finagrip) tablets should be carefully followed for signs and symptoms of gastrointestinal ulceration and bleeding. Although it is not definitely known whether Ibuprofen (Finagrip) tablets causes less peptic ulceration than aspirin, in one study involving 885 patients with rheumatoid arthritis treated for up to one year, there were no reports of gastric ulceration with Ibuprofen (Finagrip) tablets whereas frank ulceration was reported in 13 patients in the aspirin group (statistically significant p<.001).

Gastroscopic studies at varying doses show an increased tendency toward gastric irritation at higher doses. However, at comparable doses, gastric irritation is approximately half that seen with aspirin. Studies using 51Cr-tagged red cells indicate that fecal blood loss associated with Ibuprofen (Finagrip) tablets in doses up to 2400 mg daily did not exceed the normal range, and was significantly less than that seen in aspirin-treated patients.

In clinical studies in patients with rheumatoid arthritis, Ibuprofen (Finagrip) tablets have been shown to be comparable to indomethacin in controlling the signs and symptoms of disease activity and to be associated with a statistically significant reduction of the milder gastrointestinal and CNS side effects.

Ibuprofen (Finagrip) tablets may be used in combination with gold salts and/or corticosteroids.

Controlled studies have demonstrated that Ibuprofen (Finagrip) tablets are a more effective analgesic than propoxyphene for the relief of episiotomy pain, pain following dental extraction procedures, and for the relief of the symptoms of primary dysmenorrhea.

In patients with primary dysmenorrhea, Ibuprofen (Finagrip) tablets have been shown to reduce elevated levels of prostaglandin activity in the menstrual fluid and to reduce resting and active intrauterine pressure, as well as the frequency of uterine contractions. The probable mechanism of action is to inhibit prostaglandin synthesis rather than simply to provide analgesia.

The Ibuprofen (Finagrip) in Ibuprofen (Finagrip) tablets is rapidly absorbed. Peak serum Ibuprofen (Finagrip) levels are generally attained one to two hours after administration. With single doses up to 800 mg, a linear relationship exists between amount of drug administered and the integrated area under the serum drug concentration vs time curve. Above 800 mg, however, the area under the curve increases less than proportional to increases in dose. There is no evidence of drug accumulation or enzyme induction.

The administration of Ibuprofen (Finagrip) tablets either under fasting conditions or immediately before meals yields quite similar serum Ibuprofen (Finagrip) concentration-time profiles. When Ibuprofen (Finagrip) tablets are administered immediately after a meal, there is a reduction in the rate of absorption but no appreciable decrease in the extent of absorption. The bioavailability of the drug is minimally altered by the presence of food.

A bioavailability study has shown that there was no interference with the absorption of Ibuprofen (Finagrip) when Ibuprofen (Finagrip) tablets were given in conjunction with an antacid containing both aluminum hydroxide and magnesium hydroxide.

Ibuprofen (Finagrip) is rapidly metabolized and eliminated in the urine. The excretion of Ibuprofen (Finagrip) is virtually complete 24 hours after the last dose. The serum half-life is 1.8 to 2.0 hours.

Studies have shown that following ingestion of the drug, 45% to 79% of the dose was recovered in the urine within 24 hours as metabolite A (25%), (+)-2-[p-(2hydroxymethyl-propyl) phenyl] propionic acid and metabolite B (37%), (+)-2-[p-(2carboxypropyl)phenyl] propionic acid; the percentages of free and conjugated Ibuprofen (Finagrip) were approximately 1% and 14%, respectively.

Actions of Pseudoephedrine (Finagrip) in details

Pseudoephedrine (Finagrip) acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, Pseudoephedrine (Finagrip) produces vasoconstriction. Pseudoephedrine (Finagrip) relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, Pseudoephedrine (Finagrip) releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors.

How should I take Pseudoephedrine (Finagrip)?

Use Pseudoephedrine (Finagrip) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.

Do not give Pseudoephedrine (Finagrip) to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Take this medicine with a full glass of water. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time. You may need to shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

Do not take Pseudoephedrine (Finagrip) for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash. If you need surgery, tell the surgeon ahead of time that you are using Pseudoephedrine (Finagrip). You may need to stop using the medicine for a short time.

Store Pseudoephedrine (Finagrip) at room temperature away from moisture and heat.

Pseudoephedrine (Finagrip) administration

Do not crush ER drug product, swallow whole. May administer with or without food. Sudafed 24 Hour tablet may not completely dissolve and appear in stool.

Bariatric surgery: Tablet, extended release: Some institutions may have specific protocols that conflict with these recommendations; refer to institutional protocols as appropriate. ER tablets should be swallowed whole. Do not crush or chew. IR tablet, chewable tablet, capsule, oral solution, syrup, and suspension formulations are available. If safety and efficacy can be effectively monitored, no change in formulation or administration is required after bariatric surgery.

Pseudoephedrine (Finagrip) pharmacology

Pseudoephedrine (Finagrip) is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts Pseudoephedrine (Finagrip) hydrochloride and Pseudoephedrine (Finagrip) sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/Pseudoephedrine (Finagrip). Unlike antihistamines, which modify the systemic histamine-mediated allergic response, Pseudoephedrine (Finagrip) only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral Pseudoephedrine (Finagrip) over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa).



References

  1. DailyMed. "PSEUDOEPHEDRINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "IBUPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. DailyMed. "ACETAMINOPHEN; ASPIRIN; CAFFEINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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