Fixoline Uses

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Fixoline indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Bromazepam is an intermediate-acting tranquiliser, prescribed for the treatment of moderate to severe anxiety and panic disorders and for the short-term treatment of insomnia. Unlike the benzodiazepine alprazolam it does not possess any antidepressant qualities.

In low doses it diminishes anxiety and tension. In higher doses the sedative and muscle-relaxant properties appear.

Uses of Fixoline in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Fixoline is used (as an additive treatment) for relieving painful stiffness or constriction in various diseases of the muscles, nerves, spine and the joints.

Fixoline description

Fixoline is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizure-prone individuals.

Fixoline dosage


Muscle spasms

Adult: Initially, 16 mg daily.


Muscle spasms

Adult: Up to 8 mg daily.

Fixoline interactions


LEXOTAN undergoes hepatic microsomal oxidation via the cytochrome P450 liver enzymes.

Therefore, caution should be taken in patients taking medicines that inhibit the P450 liver enzymes (e.g. azole antifungals, macrolide antibiotics, HIV protease inhibitors, calcium channel blocking agents).

LEXOTAN undergoes oxidative metabolism and, consequently, may interact with disulfiram or cimetidine resulting in increased plasma levels of LEXOTAN. Patients should be observed closely for evidence of enhanced benzodiazepine response during concomitant treatment with either disulfiram or cimetidine; some patients may require a reduction in benzodiazepine dosage.

The benzodiazepines, including LEXOTAN, produce additive CNS depressant effects when coadministered with other medications which themselves produce CNS depression e.g. barbiturates, alcohol, sedatives, antidepressants, hypnotics, anxiolytics, phenothiazines and other antipsychotics,

skeletal muscle relaxants, antihistamines, narcotic analgesics and anaesthetics.

Alcohol should be avoided in patients receiving LEXOTAN.

In the case of narcotic analgesics enhancement of euphoria may also occur, leading to an increase in psychic drug dependence.

The anticholinergic effects of atropine and similar medicines, antihistamines and antidepressants may be potentiated.

Interactions have been reported between some benzodiazepines and anticonvulsants, with changes in the serum concentration of the benzodiazepine or anticonvulsant. It is recommended that patients be observed for altered responses when benzodiazepines and anticonvulsants are prescribed together and that serum level monitoring of the anticonvulsant be performed more frequently.

Interference with Clinical, Laboratory or Other Tests:

Minor EEG changes, usually low voltage fast activity, of no known clinical significance, has been

reported with benzodiazepine administration.

Fixoline side effects


Photosensitivity reactions,Fixoline Tablets and capsules may cause irritation of the digestive system. Therefore, your doctor Fixoline tablets / capsules during your use of gastric protective drugs may tell you to use. Follow your doctor’s instructions.

If diarrhea occurs In such a situation should reduce your dosage. Fixoline rest, physical therapy and other measures, including pain relief is only one part of the complete treatment program.

Avoid drinking alcohol. Alkol Fixoline alcohol may increase some side effects.

Fixoline contraindications

If you are allergic to any drugs, or if you have any of the following conditions inform your doctor before using Fixoline:

kidney disease;

bleeding problems; The drugs prevent blood clotting [warfarin sodium ( Coumadin )] utilization.

Active ingredient matches for Fixoline:

Thiocolchicoside in Turkey.

List of Fixoline substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Fenpan-T Aceclofenac 100 mg, thiocolchicoside 4 mg. TAB / 10$ 1.75
Kedac-T Aceclofenac 100 mg, thiocolchicoside 4 mg. TAB / 10 (Aden Healthcare)$ 2.14
KEDAC-T tab 10's (Aden Healthcare)$ 2.14
Kolchilax 4mg Capsule (Psychotropics India Ltd)$ 0.14
Kolchilax 8mg Capsule (Psychotropics India Ltd)$ 0.25
MIOFREE - 4 CAPSULE 1 strip / 10 capsules each (Lupin)$ 1.71
MIOFREE cap 4 mg x 10's (Lupin)$ 1.71
MIOFREE cap 8 mg x 10's (Lupin)$ 3.05
Miofree 4mg Capsule (Lupin)$ 0.19
Mobiwok 4mg CAP / 10 (Wockhardt (Merind))
Mobiwok 8mg CAP / 10 (Wockhardt (Merind))
Mobiwok 4mg AMP / 2ml (Wockhardt (Merind))
MOBIWOK 4 MG CAPSULE 1 strip / 10 capsules each (Wockhardt (Merind))$ 1.48
MOBIWOK cap 4 mg x 10's (Wockhardt (Merind))$ 1.54
MOBIWOK cap 8 mg x 10's (Wockhardt (Merind))$ 2.72
MOBIWOK inj 4 mg x 2ml (Wockhardt (Merind))$ 0.41
Mobiwok 4mg Capsule (Wockhardt (Merind))$ 0.15
Capsule; Oral; Thiocolchicoside 4 mg (Sanofi-aventis)
4 mg x 100's (Obsurge)
Muscodol 4mg CAP / 100 (Obsurge)
MUSCODOL 150 MG TABLET 1 strip / 10 tablets each (Obsurge)$ 1.21


  1. PubChem. "Thiocolchicoside". (accessed September 17, 2018).
  2. DrugBank. "Thiocolchicoside". (accessed September 17, 2018).
  3. MeSH. "MeSH Tree: MeSH (Medical Subject Headings) is the NLM controlled vocabulary thesaurus used for indexing articles for PubMed.". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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