Bromazepam is an intermediate-acting tranquiliser, prescribed for the treatment of moderate to severe anxiety and panic disorders and for the short-term treatment of insomnia. Unlike the benzodiazepine alprazolam it does not possess any antidepressant qualities.
In low doses it diminishes anxiety and tension. In higher doses the sedative and muscle-relaxant properties appear.
Fixoline is used (as an additive treatment) for relieving painful stiffness or constriction in various diseases of the muscles, nerves, spine and the joints.
Fixoline is a muscle relaxant with anti-inflammatory and analgesic effects. It acts as a competitive GABAA receptor antagonist and also glycine receptor antagonist with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizure-prone individuals.
Adult: Initially, 16 mg daily.
Adult: Up to 8 mg daily.
LEXOTAN undergoes hepatic microsomal oxidation via the cytochrome P450 liver enzymes.
Therefore, caution should be taken in patients taking medicines that inhibit the P450 liver enzymes (e.g. azole antifungals, macrolide antibiotics, HIV protease inhibitors, calcium channel blocking agents).
LEXOTAN undergoes oxidative metabolism and, consequently, may interact with disulfiram or cimetidine resulting in increased plasma levels of LEXOTAN. Patients should be observed closely for evidence of enhanced benzodiazepine response during concomitant treatment with either disulfiram or cimetidine; some patients may require a reduction in benzodiazepine dosage.
The benzodiazepines, including LEXOTAN, produce additive CNS depressant effects when coadministered with other medications which themselves produce CNS depression e.g. barbiturates, alcohol, sedatives, antidepressants, hypnotics, anxiolytics, phenothiazines and other antipsychotics,
skeletal muscle relaxants, antihistamines, narcotic analgesics and anaesthetics.
Alcohol should be avoided in patients receiving LEXOTAN.
In the case of narcotic analgesics enhancement of euphoria may also occur, leading to an increase in psychic drug dependence.
The anticholinergic effects of atropine and similar medicines, antihistamines and antidepressants may be potentiated.
Interactions have been reported between some benzodiazepines and anticonvulsants, with changes in the serum concentration of the benzodiazepine or anticonvulsant. It is recommended that patients be observed for altered responses when benzodiazepines and anticonvulsants are prescribed together and that serum level monitoring of the anticonvulsant be performed more frequently.
Interference with Clinical, Laboratory or Other Tests:
Minor EEG changes, usually low voltage fast activity, of no known clinical significance, has been
reported with benzodiazepine administration.
Photosensitivity reactions,Fixoline Tablets and capsules may cause irritation of the digestive system. Therefore, your doctor Fixoline tablets / capsules during your use of gastric protective drugs may tell you to use. Follow your doctor’s instructions.
If diarrhea occurs In such a situation should reduce your dosage. Fixoline rest, physical therapy and other measures, including pain relief is only one part of the complete treatment program.
Avoid drinking alcohol. Alkol Fixoline alcohol may increase some side effects.
If you are allergic to any drugs, or if you have any of the following conditions inform your doctor before using Fixoline:
bleeding problems; The drugs prevent blood clotting [warfarin sodium ( Coumadin )] utilization.
Thiocolchicoside in Turkey.
List of Fixoline substitutes (brand and generic names)
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|Unit description / dosage (Manufacturer)||Price, USD|
|Fenpan-T Aceclofenac 100 mg, thiocolchicoside 4 mg. TAB / 10||$ 1.75|
|Haliver 0.25% (Greece)|
|Kedac-T Aceclofenac 100 mg, thiocolchicoside 4 mg. TAB / 10 (Aden Healthcare)||$ 2.14|
|KEDAC-T tab 10's (Aden Healthcare)||$ 2.14|
|Kolchilax 4mg Capsule (Psychotropics India Ltd)||$ 0.14|
|Kolchilax 8mg Capsule (Psychotropics India Ltd)||$ 0.25|
|MIOFREE - 4 CAPSULE 1 strip / 10 capsules each (Lupin)||$ 1.71|
|MIOFREE cap 4 mg x 10's (Lupin)||$ 1.71|
|MIOFREE cap 8 mg x 10's (Lupin)||$ 3.05|
|Miofree 4mg Capsule (Lupin)||$ 0.19|
|Miotens contratture e Dolore (Italy)|
|Mobiwok 4mg CAP / 10 (Wockhardt (Merind))|
|Mobiwok 8mg CAP / 10 (Wockhardt (Merind))|
|Mobiwok 4mg AMP / 2ml (Wockhardt (Merind))|
|MOBIWOK 4 MG CAPSULE 1 strip / 10 capsules each (Wockhardt (Merind))||$ 1.48|
|MOBIWOK cap 4 mg x 10's (Wockhardt (Merind))||$ 1.54|
|MOBIWOK cap 8 mg x 10's (Wockhardt (Merind))||$ 2.72|
|MOBIWOK inj 4 mg x 2ml (Wockhardt (Merind))||$ 0.41|
|Mobiwok 4mg Capsule (Wockhardt (Merind))||$ 0.15|
|Capsule; Oral; Thiocolchicoside 4 mg (Sanofi-aventis)|
|4 mg x 100's (Obsurge)|
|Muscodol 4mg CAP / 100 (Obsurge)|
|MUSCODOL 150 MG TABLET 1 strip / 10 tablets each (Obsurge)||$ 1.21|
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Information checked by Dr. Sachin Kumar, MD Pharmacology