Flupentixol/Melitracen Uses

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Flupentixol/Melitracen indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Anxiety, depression, asthenia. Psychogenic depressions, depressive neuroses. Masked depression. Psychosomatic affections accompanied by anxiety & apathy. Menopausal depression.

Flupentixol/Melitracen description

Each tablet contains flupentixol (as dihydrochloride) 0.5 mg and melitracen (as hydrochloride) 10 mg.

Flupentixol/Melitracen also contains the following excipients: Tablet Core: Lactose monohydrate, potato starch, talc, gelatin, magnesium stearate. Coating: Gelatin, sucrose, sucrose powder, Flupentixol/Melitracen colour (erythrosine E127 and indigotine E132). Polishing Wax: Capol 1295 (a mixture of beeswax, white and carnauba wax).

Flupentixol/Melitracen dosage

Adults: Usually 2 tablets daily, morning and noon. In severe cases, the morning dose may be increased to 2 tablets. Maximum Dose: 4 tablets daily.

Elderly (>65 years): 1 tablet in the morning. In severe cases, 1 tablet in the morning and 1 at noon.

Maintenance Dose: Usually 1 tablet in the morning.

In cases of insomnia or severe restlessness, additional treatment with a sedative in the acute phase is recommended.

Reduced Renal and Liver Function: Flupentixol/Melitracen can be given in the recommended doses.

Administration: The tablets are swallowed with water.

Flupentixol/Melitracen interactions


Contraindicated Combinations: Monoamine oxidase inhibitors [nonselective as well as selective A (moclobemide) and B (selegiline)], risk of "serotonin syndrome".

Inadvisable Combinations: Sympathomimetic Agents: Melitracen may potentiate the cardiovascular effects of adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine (eg, as contained in local and general anaesthetics and nasal decongestants).

Adrenergic Neurone Blockers: Flupentixol/Melitracen may counteract the antihypertensive effects of guanethidine, betanidine, reserpine, clonidine and methyldopa. It is advisable to review all antihypertensive therapy during treatment with tricyclic antidepressants.

Anticholinergic Agents: Tricyclic antidepressants may potentiate the effects of these drugs on the eye, central nervous system (CNS), bowel and bladder; concomitant use of these should be avoided due to an increased risk of paralytic ileus, hyperpyrexia.

Drugs Which May Increase the QT Interval: Increases in the QT interval related to antipsychotic treatment may be exacerbated by the co-administration of other drugs known to significantly increase the QT interval. Co-administration of such drugs should be avoided. Relevant classes include: Class Ia and III antiarrhythmics (eg, quinidine, amiodarone, sotalol, dofetilide); some antipsychotics (eg, thioridazine); some macrolides (eg, erythromycin); some antihistamine (eg, terfenadine, astemizole); some quinolone antibiotics (eg, gatifloxacin, moxifloxacin).

The list mentioned is not exhaustive and other individual drugs known to significantly increase QT interval (eg, cisapride, lithium) should be avoided.

Drugs known to cause electrolyte disturbances eg, thiazide diuretica (hypokalaemia) and drugs known to increase the plasma concentration of flupentixol should also be used with caution as they may increase the risk of QT prolongation and malignant arrhythmias.

Combinations Requiring Precautions for Use: Central Nervous System Depressants: Flupentixol/Melitracen may enhance the effects of alcohol, barbiturates and other CNS depressants.

Lithium: Concomitant use of Flupentixol/Melitracen and lithium increases the risk of neurotoxicity.

Levodopa: Flupentixol/Melitracen may reduce the effect of levodopa and increase the risk of cardiac side effects.

Incompatibilities: Not applicable.

Flupentixol/Melitracen side effects


Dryness of the mouth, dizziness, tremor, nervousness, blurred vision and insomnia are the most frequent adverse effects and occur commonly.

In the listing as follows, the following convention is used: MedDRA system organ class or preferred term.

Frequencies are defined as: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000 to <1/1,000); very rare (<1/10,000); or not known (cannot be estimated from available data).

Post-Marketing: Isolated cases of cholestatic hepatitis have been reported.

Reporting of Suspected Adverse Reactions: Reporting of suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system.

Flupentixol/Melitracen contraindications

Hypersensitivity to flupentixol or melitracen or to any of the excipients of Flupentixol/Melitracen.

Circulatory collapse, depressed level of consciousness due to any cause (eg, intoxication with alcohol, barbiturates or opiates), coma, blood disorders, phaeochromocytoma.

Recent myocardial infarction. Any degree of atrioventricular block or disorders of cardiac rhythm and coronary artery insufficiency.

Concomitant treatment with monoamine oxidase inhibitors (MAOIs) is contraindicated. Simultaneous administration of melitracen and MAOIs may cause serotonin syndrome (a combination of symptoms, possibly including agitation, confusion, tremor, myoclonus and hyperthermia).

As with other tricyclic antidepressants, melitracen should not be given to patients receiving MAOIs. Treatment with Flupentixol/Melitracen may be instituted 14 days after discontinuation of nonselective MAOIs and minimum 1 day after discontinuation of moclobemide and selegiline. Treatment with MAOIs may be introduced 14 days after discontinuation of Flupentixol/Melitracen.

Active ingredient matches for Flupentixol/Melitracen:


List of Flupentixol/Melitracen substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Flupen-M Flupentixol 0.5mg, melitracen10mg TAB / 10$ 0.71
Fluxit 20 mg Capsule (Alpic Remedies Ltd.)$ 0.03
Forcalm flupentixol 10mg, melitracen0.5mg TAB / 10 (Unichem Laboratories Ltd.)$ 0.71
10's (Unichem Laboratories Ltd.)$ 0.71
Forcalm 10+0.5 Tablet (Unichem Laboratories Ltd.)$ 0.07
FORCALM 10MG/0.5MG TABLET 1 strip / 10 tablets each (Unichem Laboratories Ltd.)$ 0.78
Franxit Flupenthixol 0.5 mg, Melitracen 10 mg. TAB / 10 (Intas Pharmaceuticals Ltd.)$ 0.68
10's (Intas Pharmaceuticals Ltd.)$ 0.68
Franxit 10+0.5 Tablet (Intas Pharmaceuticals Ltd.)$ 0.08
FRANXIT 0.5 MG/10 MG TABLET 1 strip / 10 tablets each (Intas Pharmaceuticals Ltd.)$ 0.86
Franxit 0.5 mg/10 mg Tablet (Intas Pharmaceuticals Ltd.)$ 0.09
Fycida-M Flupenthixol 0.5 mg, Melitracen 10 mg. TAB / 100
Melicen -FP flupentixol 0.5mg, melitracen10mg FC-TAB / 100$ 7.94
Melixol 1000's
MELIXOL 10MG/0.5MG TABLET 1 strip / 10 tablets each (Reliance Formulation Pvt Ltd)$ 0.81
Melixol 10 mg/0.5 mg Tablet (Reliance Formulation Pvt Ltd)$ 0.08
Meliyos Flupentixol 0.5 mg, Melitracenhydrochloride 10 mg. TAB / 10$ 0.79
10's$ 0.79
10's$ 0.76
Melthix flupentixol 0.5mg, melitracen10mg SC-TAB / 10$ 0.76
MELTHIX 0.5MG/10MG TABLET 1 strip / 10 tablets each (Molekule India Pvt Ltd)$ 0.91
Melthix flupentixol 0.5mg, melitracen10mg SC-TAB / 10$ 0.76
Melxol Flupentixol 0.5 mg, Melitracenhydrochloride 10 mg. TAB / 10$ 0.94
10's$ 0.94
Modaxit Flupentixol 0.5 mg, Melitracen10 mg. TAB / 10$ 0.87
10's$ 0.87
Moody Flupentixol dihydrochloride0.5 mg, Melitracenhydrochloride 10 mg. TAB / 100$ 7.62
100's$ 7.62
MOODY 0.5MG/10MG TABLET 1 strip / 10 tablets each (Cure Quick Pharmaceuticals)$ 0.76
Moody 0.5 mg/10 mg Tablet (Cure Quick Pharmaceuticals)$ 0.08
Novoxit Flupentixol 0.5 mg, Melitracen10 mg. TAB / 100 (Novogen Captab Biotec (Novo Nordisk Pharma India Ltd))$ 8.33


  1. PubChem. "Flupentixol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "Flupentixol". http://www.drugbank.ca/drugs/DB00875 (accessed September 17, 2018).
  3. MeSH. "Antipsychotic Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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