What happens if I overdose Fluvir?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include nausea or vomiting.
Proper storage of Fluvir suspension:
Store Fluvir suspension in the refrigerator for up to 17 days. Do not freeze. Fluvir suspension may be stored at room temperature for up to 10 days. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fluvir suspension out of the reach of children and away from pets.
Overdose of Fluvir in details
Reports of overdoses with Fluvir capsules have been received from clinical trials and during postmarketing experience. In the majority of cases reporting overdose, no adverse reactions were reported. Adverse reactions reported following overdose were similar in nature to those observed with therapeutic doses of Fluvir capsules.
What should I avoid while taking Fluvir?
Do not use a nasal flu vaccine (FluMist) within 48 hours after taking Fluvir. Fluvir may interfere with the drug action of FluMist, making the vaccine less effective. Follow your doctor's instructions.
Fluvir warnings
Serious Skin/Hypersensitivity Reactions
Cases of anaphylaxis and serious skin reactions including toxic epidermal necrolysis, Stevens-Johnson Syndrome, and erythema multiforme have been reported in postmarketing experience with Fluvir capsules. Stop Fluvir capsules and institute appropriate treatment if an allergic-like reaction occurs or is suspected. The use of Fluvir capsules is contraindicated in patients with known serious hypersensitivity to Fluvir capsules.
Neuropsychiatric Events
There have been postmarketing reports (mostly from Japan) of delirium and abnormal behavior leading to injury, and in some cases resulting in fatal outcomes, in patients with influenza who were receiving Fluvir capsules. Because these events were reported voluntarily during clinical practice, estimates of frequency cannot be made but they appear to be uncommon based on Fluvir capsules usage data. These events were reported primarily among pediatric patients and often had an abrupt onset and rapid resolution. The contribution of Fluvir capsules to these events has not been established. Influenza can be associated with a variety of neurologic and behavioral symptoms that can include events such as hallucinations, delirium, and abnormal behavior, in some cases resulting in fatal outcomes. These events may occur in the setting of encephalitis or encephalopathy but can occur without obvious severe disease. Closely monitor Fluvir capsules-treated patients with influenza for signs of abnormal behavior. If neuropsychiatric symptoms occur, evaluate the risks and benefits of continuing Fluvir capsules for each patient.
Risk of Bacterial Infections
There is no evidence for efficacy of Fluvir capsules in any illness caused by pathogens other than influenza viruses. Serious bacterial infections may begin with influenza-like symptoms or may coexist with or occur as complications during the course of influenza. Fluvir capsules have not been shown to prevent such complications. Prescribers should be alert to the potential for secondary bacterial infections and treat them as appropriate.
What should I discuss with my healthcare provider before taking Fluvir?
Some medical conditions may interact with Fluvir suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have kidney problems, liver problems, heart problems, breathing problems, or mood or mental problems
- if you have a history of fructose (fruit sugar) intolerance
Some MEDICINES MAY INTERACT with Fluvir suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Intranasal live attenuated influenza vaccine because its effectiveness may be decreased by Fluvir suspension
- Anticoagulants (eg, warfarin) or medicines for arrhythmias (eg, sotalol) because the risk of their side effects may be increased with Fluvir suspension
This may not be a complete list of all interactions that may occur. Ask your health care provider if Fluvir suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Fluvir precautions
Serious Skin/Hypersensitivity Reactions
Cases of anaphylaxis and serious skin reactions including toxic epidermal necrolysis, Stevens-Johnson Syndrome, and erythema multiforme have been reported in postmarketing experience with Fluvir capsules. Stop Fluvir capsules and institute appropriate treatment if an allergic-like reaction occurs or is suspected. The use of Fluvir capsules is contraindicated in patients with known serious hypersensitivity to Fluvir capsules.
Neuropsychiatric Events
There have been postmarketing reports (mostly from Japan) of delirium and abnormal behavior leading to injury, and in some cases resulting in fatal outcomes, in patients with influenza who were receiving Fluvir capsules. Because these events were reported voluntarily during clinical practice, estimates of frequency cannot be made but they appear to be uncommon based on Fluvir capsules usage data. These events were reported primarily among pediatric patients and often had an abrupt onset and rapid resolution. The contribution of Fluvir capsules to these events has not been established. Influenza can be associated with a variety of neurologic and behavioral symptoms that can include events such as hallucinations, delirium, and abnormal behavior, in some cases resulting in fatal outcomes. These events may occur in the setting of encephalitis or encephalopathy but can occur without obvious severe disease. Closely monitor Fluvir capsules-treated patients with influenza for signs of abnormal behavior. If neuropsychiatric symptoms occur, evaluate the risks and benefits of continuing Fluvir capsules for each patient.
Risk of Bacterial Infections
There is no evidence for efficacy of Fluvir capsules in any illness caused by pathogens other than influenza viruses. Serious bacterial infections may begin with influenza-like symptoms or may coexist with or occur as complications during the course of influenza. Fluvir capsules have not been shown to prevent such complications. Prescribers should be alert to the potential for secondary bacterial infections and treat them as appropriate.
What happens if I miss a dose of Fluvir?
Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 2 hours away. Do not take extra medicine to make up the missed dose.
References
- DrugBank. "oseltamivir". http://www.drugbank.ca/drugs/DB00198 (accessed September 17, 2018).
- MeSH. "Antiviral Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
