Forticef Uses

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What is Forticef?

Forticef is in a group of drugs called cephalosporin (SEF a low spor in) antibiotics. It works by fighting bacteria in your body.

Forticef is used to treat many different types of infections caused by bacteria.

Forticef may also be used for other purposes not listed in this medication guide.

Forticef indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Forticef (Forticef) is indicated in the treatment of the following infections when caused by susceptible strains of the designated microorganisms:

Otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, staphylococci, and Streptococcus pyogenes

Note: (β-lactamase-negative, ampicillin-resistant (BLNAR) strains of Haemophilus influenzae should be considered resistant to Forticef despite apparent in vitro susceptibility of some BLNAR strains.

Lower respiratory tract infections, including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae, and Streptococcus pyogenes

Note: β-lactamase-negative, ampicillin-resistant (BLNAR) strains of Haemophilus influenzae should be considered resistant to Forticef despite apparent in vitro susceptibility of some BLNAR strains.

Pharyngitis and Tonsillitis, caused by Streptococcus pyogenes

Note: Penicillin is the usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever. Forticef (Forticef) is generally effective in the eradication of streptococci from the nasopharynx; however, substantial data establishing the efficacy of Forticef (Forticef) in the subsequent prevention of rheumatic fever are not available at present.

Urinary tract infections, including pyelonephritis and cystitis, caused by Escherichia coli, Proteus mirabilis, Klebsiella spp., and coagulase-negative staphylococci

Skin and skin structure infections caused by Staphylococcus aureus and Streptococcus pyogenes

Appropriate culture and susceptibility studies should be performed to determine susceptibility of the causative organism to Forticef.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Forticef (Forticef) and other antibacterial drugs, Forticef (Forticef) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

How should I use Forticef?

Use Forticef extended-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Forticef extended-release tablets.

Uses of Forticef in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Forticef is used to treat respiratory tract infections such as inflammation of tonsils (tonsillitis), nasopharynx (area of the upper throat that lies behind the nose), throat (pharyngitis) or air passages (bronchitis), lung (pneumonia); sinus infection (sinusitis), urinary tract infections such as urinary bladder infection (cystitis) or kidney infection (pyelonephritis); skin and soft tissue infections, and middle ear infections (otitis media).

Forticef description

Each 5 mL of suspension contains Cefaclor monohydrate equivalent to anhydrous Forticef 125 mg.

Forticef also contains sodium benzoate 0.03 g as preservative.

Forticef dosage

Forticef (Forticef) is administered orally.

Adults - The usual adult dosage is 250 mg every 8 hours. For more severe infections (such as pneumonia) or those caused by less susceptible organisms, doses may be doubled.

Pediatric patients - The usual recommended daily dosage for pediatric patients is 20 mg/kg/day in divided doses every 8 hours. In more serious infections, otitis media, and infections caused by less susceptible organisms, 40 mg/kg/day are recommended, with a maximum dosage of 1 g/day.

Forticef Suspension

20 mg/kg/day

Weight 125 mo/5 mL 250 mg/5 mL
9 kg 1/2 tsp t.i.d.
18 kg 1 tsp t.i.d. 1/2 tsp t.i.d.
40 mg/kg/day
9 kg 1 tsp t.i.d. 1/2 tsp t.i.d.
18 kg 1 tsp t.i.d.

B.I.D. Treatment Option - For the treatment of otitis media and pharyngitis, the total daily dosage may be divided and administered every 12 hours.

Forticef (Forticef) Suspension

20 mg/kg/day

(Pharyngitis)

Weight 187 ms/5 mL 375 ms/5 mL
9 kg 1/2 tsp b.i.d.
18 kg 1 tsp b.i.d. 1/2 tsp b.i.d.
40 mg/kg/day

(Otitis Media)

9 kg 1 tsp b.i.d. 1/2 tsp b.i.d.
18 kg 1 tsp b.i.d.

Forticef (Forticef) may be administered in the presence of impaired renal function. Under such a condition, the dosage usually is unchanged.

In the treatment of p-hemolytic streptococcal infections, a therapeutic dosage of Forticef (Forticef) should be administered for at least 10 days.

How supplied

Pulvules:

250 mg, purple and white (No. 3061) - (RxPak* of 15)

NDC 0002-3061-15; (100s)

NDC 0002-3061-02; (ID After mixing, store in a refrigerator. Shake well before using. Keep tightly closed. The mixture may be kept for 14 days without significant loss of potency. Discard unused portion after 14 days.

Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F)

Literature revised March 28, 2003. Manufactured by: Eli Lilly Italia, S.p. A. Sesto Florentino (Firenze), Italy for Eli Lilly and Company Indianapolis, IN 46285, USA. FDA Rev date: 3/17/2004

Forticef interactions

See also:
What other drugs will affect Forticef?

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Patients receiving Forticef may show a false-positive reaction for glucose in the urine with tests that use Benedict's and Fehling's solutions and also with Clinitest tablets but not with Tes-Tape (Glucose enzymatic test strip, USP, Lilly).

There have been rare reports of increased anticoagulant effect when Forticef and oral anticoagulants were administered concomitantly.

As with other β-lactam antibiotics, the renal excretion of Forticef is inhibited by probenecid.

Forticef side effects

See also:
What are the possible side effects of Forticef?

Clinical Trials

There were 3272 patients treated with multiple doses of Forticef extended-release tablets in controlled clinical trials and an additional 211 subjects in pharmacology studies. There were no deaths in these trials thought to be related to toxicity from Forticef extended-release tablets. Treatment was discontinued in 1.7% of patients due to adverse events thought to be possibly or probably drug-related.

The following adverse clinical and laboratory events were reported during the Forticef extended-release tablets clinical trials conducted in North America at doses of 375 mg or 500 mg BID; however, relatedness of the adverse events to the drug was not assigned by clinical investigators during the trials.

Adverse reactions occurring during the clinical trials with Forticef extended-release tablets with an incidence of less than 1% but greater than 0.1% included the following (listed alphabetically):

Accidental injury, anorexia, anxiety, arthralgia, asthma, bronchitis, chest pain, chills, congestive heart failure, conjunctivitis, constipation, dizziness, dysmenorrhea, dyspepsia, dysuria, ear pain, edema, fever, flatulence, flu syndrome, gastritis, infection, insomnia, leukorrhea, lung disorder, maculopapular rash, malaise, menstrual disorder, myalgia, nausea and vomiting, neck pain, nervousness, nocturia, otitis media, pain, palpitation, peripheral edema, rash, respiratory disorder, sinusitis, somnolence, surgical procedure, sweating, tremor, urticaria, vomiting.

NOTE: One case of serum-sickness-like reaction was reported among the 3272 adult patients treated with Forticef extended-release tablets during the controlled clinical trials. These reactions have also been reported with the use of Forticef in other oral formulations and are seen more frequently in pediatric patients than in adults. These reactions are characterized by findings of erythema multiforme, rash, and other skin manifestations accompanied by arthritis/arthralgia, with or without fever, and differ from classic serum sickness in that there is infrequently associated lymphadenopathy and proteinuria, no circulating immune complexes and no evidence to date of sequelae of the reaction. While further investigation is ongoing, serum-sickness-like reactions appear to be due to hypersensitivity and more often occur during or following a second (or subsequent) course of therapy with Forticef. Such reactions have been reported with overall occurrence ranging from 1 in 200 (0.5%) in one focused trial; to 2 in 8346 (0.024%) in overall clinical trials (with an incidence in pediatric patients in clinical trials of 0.055%); to 1 in 38,000 (0.003%) in spontaneous event reports. Signs and symptoms usually occur a few days after initiation of therapy and subside within a few days after cessation of therapy. Occasionally these reactions have resulted in hospitalization, usually of short duration (median hospitalization = 2 to 3 days, based on postmarketing surveillance studies). In those patients requiring hospitalization, the symptoms have ranged from mild to severe at the time of admission with more of the severe reactions occurring in pediatric patients.

In Postmarketing Experience

In addition to the events reported during clinical trials with Forticef extended-release tablets, the following adverse experiences are among those that have been reported during worldwide postmarketing surveillance: allergic reaction, anaphylactoid reaction, angioedema, face edema, hypotension, Stevens-Johnson syndrome, syncope, paresthesia, vasodilatation and vertigo.

Other Adverse Reactions Associated With Other Formulations of Forticef

In addition to the above, the following other adverse reactions and altered laboratory tests have been associated with Forticef in other oral formulations:

Clinical

Severe hypersensitivity reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, and anaphylaxis, have been reported rarely. Anaphylactoid events may be manifested by solitary symptoms, including angioedema, edema (including face and limbs), paresthesias, syncope, or vasodilatation. Anaphylaxis may be more common in patients with a history of penicillin allergy. Rarely, hypersensitivity symptoms may persist for several months.

Symptoms of pseudomembranous colitis may appear either during or after antibiotic treatment.

Laboratory

Abnormal urinalysis, eosinophilia, leukopenia, neutropenia, transient elevations in AST, and transient thrombocytopenia have been reported.

Cephalosporin-Class Reactions

In addition to the adverse reactions listed above, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:

Clinical

Confusion, erythema multiforme, genital pruritus, hepatic dysfunction including cholestasis, hemolytic anemia, reversible hyperactivity, hypertonia, and reversible interstitial nephritis.

Laboratory

Positive direct Coombs’ test.

Forticef contraindications

See also:
What is the most important information I should know about Forticef?

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Forticef extended-release tablets are contraindicated in patients with known hypersensitivity to Forticef and other cephalosporins.

Active ingredient matches for Forticef:

Cefaclor in Oman.


List of Forticef substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Forifek 125 mg/5 mL x 60 mL x 1's (Caprifarmindo)$ 7.86
Fracef 125 mg x 1 Packs (Frank Medilink)
Fracef 250 mg Injection (Frank Medilink)$ 0.51
Fracef 1000 mg Injection (Frank Medilink)$ 1.11
Fracef 500 mg Injection (Frank Medilink)$ 0.71
Gcef 1000 mg Injection (Greenray Pharmaceuticals (P) Ltd)$ 1.06
Gcef 500 mg Injection (Greenray Pharmaceuticals (P) Ltd)$ 0.70
Gcef 250 mg Injection (Greenray Pharmaceuticals (P) Ltd)$ 0.46
Suspension; Oral; Cefaclor 125 mg / 5 ml
Suspension; Oral; Cefaclor 250 mg / 5 ml
Tablet; Oral; Cefaclor Monohydrate 375 mg
Geof-Cefaclor 125 mg x 1 Bottle x 60 mL
HALCLOR Capsule/ Tablet / 250mg / 10 units (Hindustan Antibiotics Ltd.)$ 3.25
Halclor 250mg CAP / 1 (Hindustan Antibiotics Ltd.)$ 3.25
250 mg x 1's (Hindustan Antibiotics Ltd.)$ 3.25
Halclor 250 mg Capsule (Hindustan Antibiotics Ltd.)$ 0.33
HALCLOR cap 250 mg x 10's (Hindustan Antibiotics Ltd.)$ 3.25
Halclor 250mg CAP / 1 (Hindustan Antibiotics Ltd.)$ 3.25
HALOCEF Liquid / 125mg per 5ml / 30ml units (Otsira Genetica (Aristo Pharmaceuticals Pvt Ltd.))$ 0.95
HALOCEF Drops / 50mg per ml / 10ml units (Otsira Genetica (Aristo Pharmaceuticals Pvt Ltd.))$ 0.65
Halocef 250mg CAP / 6 (Otsira Genetica (Aristo Pharmaceuticals Pvt Ltd.))$ 1.83
Halocef 500mg CAP / 3 (Otsira Genetica (Aristo Pharmaceuticals Pvt Ltd.))$ 1.81
250 mg x 6's (Otsira Genetica (Aristo Pharmaceuticals Pvt Ltd.))$ 1.83
500 mg x 3's (Otsira Genetica (Aristo Pharmaceuticals Pvt Ltd.))$ 1.81
Halocef 50 mg Syrup (Otsira Genetica (Aristo Pharmaceuticals Pvt Ltd.))$ 0.02
Halocef 500 mg Capsule (Otsira Genetica (Aristo Pharmaceuticals Pvt Ltd.))$ 0.60
Halocef 250 mg Capsule (Otsira Genetica (Aristo Pharmaceuticals Pvt Ltd.))$ 0.30
HALOCEF 125MG SUSPENSION 1 bottle / 30 ML suspension each (Otsira Genetica (Aristo Pharmaceuticals Pvt Ltd.))$ 1.10

References

  1. DailyMed. "CEFACLOR: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "cefaclor". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "cefaclor". http://www.drugbank.ca/drugs/DB00833 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Forticef are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Forticef. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

2 consumers reported useful

Was the Forticef drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Useful2
100.0%


1 consumer reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Forticef drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Expensive1
100.0%


2 consumers reported time for results

To what extent do I have to use Forticef before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 1 day and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Forticef. To get the time effectiveness of using Forticef drug by other patients, please click here.
Users%
1 day1
50.0%
3 days1
50.0%


9 consumers reported age

Users%
16-294
44.4%
< 13
33.3%
> 601
11.1%
46-601
11.1%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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