Fructofuranose Uses

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What is Fructofuranose?

Fructofuranose is a type of sugar. It is broken down in the large intestine into mild acids that draw water into the colon, which helps soften the stools.

Fructofuranose is used to treat chronic constipation.

Fructofuranose is sometimes used to treat or prevent certain conditions of the brain that are caused by liver failure, which can lead to confusion, problems with memory or thinking, behavior changes, tremors, feeling irritable, sleep problems, loss of coordination, and loss of consciousness.

Fructofuranose may also be used for purposes not listed in this medication guide.

Fructofuranose indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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For the prevention and treatment of portal-systemic encephalopathy, including the stages of hepatic pre-coma and coma.

Controlled studies have shown that Fructofuranose therapy reduces the blood ammonia levels by 25–50%; this is generally paralleled by an improvement in the patients' mental state and by an improvement in EEG patterns. The clinical response has been observed in about 75% of patients, which is at least as satisfactory as that resulting from neomycin therapy. An increase in patients' protein tolerance is also frequently observed with Fructofuranose solution therapy. In the treatment of chronic portal-systemic encephalopathy, Fructofuranose solution has been given for over 2 years in controlled studies.

How should I use Fructofuranose?

Use Fructofuranose crystals as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Fructofuranose crystals.

Uses of Fructofuranose in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This medication is a laxative used to treat constipation. It may help to increase the number of bowel movements per day and the number of days you have a bowel movement. Fructofuranose is a colonic acidifier that works by increasing stool water content and softening the stool. It is a man-made sugar solution.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug, but may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if has been so prescribed by your health care professional.

This drug is also used to treat or prevent complications of liver disease (hepatic encephalopathy).

How to use Fructofuranose

Take this medication by mouth, usually once daily for constipation, or as directed by your doctor. If you are taking the solution, to improve the taste, you may mix it into fruit juice, water, milk, or a soft dessert. If you are using the crystals in packets, dissolve the contents of the packet in half a glass of water (4 ounces or 120 milliliters), or as directed by your doctor.

Use this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. Dosage is based on your medical condition and response to therapy.

It may take up to 48 hours to have a bowel movement. Inform your doctor if your condition persists or worsens.

Fructofuranose description

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Fructofuranose syrup, which contains Lactulose with other sugars eg, galactose and lactose, is used in the treatment of constipation and hepatic encephalopathy. Fructofuranose is a disaccharide, a sugar molecule composed of 2 smaller sugar molecules bonded together, in this case, fructose and galactose. Fructofuranose is a solid substance that is very soluble in water and has a sweet taste. It is sweeter than lactose but not as sweet as fructose. Chemically, Fructofuranose is also known as 4-O-β-D-galactopyranosyl-D-fructofuranose. The molecular formula is C12H22O11 with a molecular weight of 342.3 daltons.

Fructofuranose dosage

Fructofuranose Dosage

Generic name: Fructofuranose 10g in 15mL

Dosage form: oral solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Oral

Adult

The usual adult oral dosage is 30 to 45 mL (2 to 3 tablespoonfuls, containing 20 g to 30 g of Fructofuranose Solution) three or four times daily. The dosage may be adjusted every day or two to produce 2 or 3 soft stools daily.

Hourly doses of 30 to 45 mL of Fructofuranose Solution may be used to induce the rapid laxation indicated in the initial phase of the therapy of portal-systemic encephalopathy. When the laxative effect has been achieved, the dose of Fructofuranose Solution may then be reduced to the recommended daily dose. Improvement in the patient's condition may occur within 24 hours but may not begin before 48 hours or even later.

Continuous long-term therapy is indicated to lessen the severity and prevent the recurrence of portal-systemic encephalopathy. The dose of Fructofuranose Solution for this purpose is the same as the recommended daily dose.

Pediatric

Very little information on the use of Fructofuranose in pediatric patients has been recorded. As with adults, the subjective goal in proper treatment is to produce 2 to 3 soft stools daily. On the basis of information available, the recommended initial daily oral dose in infants is 2.5 to 10 mL in divided doses. For older pediatric patients, the total daily dose is 40 to 90 mL. If the initial dose causes diarrhea, the dose should be reduced immediately. If diarrhea persists, Fructofuranose Solution should be discontinued.

Rectal

When the adult patient is in the impending coma or coma stage of portal-systemic encephalopathy and the danger of aspiration exists, or when the necessary endoscopic or intubation procedures physically interfere with the administration of the recommended oral doses, Fructofuranose Solution may be given as a retention enema via a rectal balloon catheter. Cleansing enemas containing soapsuds or other alkaline agents should not be used.

Three hundred mL of Fructofuranose Solution should be mixed with 700 mL of water or physiologic saline and retained for 30 to 60 minutes. Fructofuranose Solution enema may be repeated every 4 to 6 hours. If the enema is inadvertently evacuated too promptly, it may be repeated immediately.

The goal of treatment is reversal of the coma stage in order that the patient may be able to take oral medication. Reversal of coma may take place within 2 hours of the first enema in some patients. Fructofuranose Solution, given orally in the recommended doses, should be started before Fructofuranose Solution by enema is stopped entirely.

More about Fructofuranose (Fructofuranose)

Consumer resources

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Related treatment guides

Fructofuranose interactions

See also:
What other drugs will affect Fructofuranose?

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No laxative should be taken within 2 hrs of another medication because the desired effect of the other medication may be reduced.

Antacids: Antacids given concurrently with Fructofuranose may inhibit the desired Fructofuranose-induced drop in colonic pH. Therefore, a possible lack of desired effect of treatment should be taken into consideration before such drugs are given concomitantly with Fructofuranose.

Neomycin: In some situations, neomycin administered together with Fructofuranose is more effective than either one alone.

Although, theoretically, the elimination of certain colonic bacteria by neomycin and possibly other anti-infective agents may interfere with the desired degradation of Fructofuranose and thus prevent the acidification of colonic contents. There have been some reports that Fructofuranose-fermenting bacteria are relatively resistant to neomycin, which may explain why a combination could work in some cases. The status of the Fructofuranose-treated patients should be closely monitored in the event of concomitant oral antibiotic therapy.

Fructofuranose side effects

See also:
What are the possible side effects of Fructofuranose?

Summary of the Safety Profile: Flatulence may occur during the 1st few days of treatment. As a rule, it disappears after a few days. When dosages higher than instructed are used, abdominal pain and diarrhea may occur. In such cases, the dosage should be decreased.

If high doses (normally only associated with, hepatic encephalopathy or portal systemic encephalopathy) are used for an extended period of time, the patient may experience an electrolyte imbalance due to diarrhea.

List of Adverse Reactions: The following undesirable effects have been experienced with the following indicated frequencies in Fructofuranose-treated patients in placebo-controlled clinical trials: Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1000 to <1/100); rare (≥1/10,000 to <1/1000); very rare (<1/10,000). Gastrointestinal Disorders: Very Common: Diarrhea. Common: Flatulence, abdominal pain, nausea, vomiting.

Investigations: Uncommon: Electrolyte imbalance due to diarrhea.

Paediatric Population: The safety profile in children is expected to be similar as in adults.

Fructofuranose contraindications

See also:
What is the most important information I should know about Fructofuranose?

Since KRISTALOSEā„¢ (D-Fructofuranose) for

Oral Solution contains galactose (less than 0.3 g/10 g as a total sum with lactose), it is contraindicated in patients who require a low galactose diet.

Active ingredient matches for Fructofuranose:

Lactulose


List of Fructofuranose substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Fresky NA Solution (Aamorb (St. Morison))$ 2.53
Syrup; Oral; Lactulose 670 mg / ml (Melisana)
Liquid; Oral; Lactulose 667 mg / ml (Genpharm)
Solution; Oral, Rectal; Lactulose 10 g / 15 ml
Generlac solution 10 g/15mL (Morton Grove Pharmaceuticals, Inc. (US))
GENTALOSE SYRUP 1 bottle / 100 ML syrup each (Biocon)$ 1.25
GENTALOSE SYRUP 1 bottle / 200 ML syrup each (Biocon)$ 2.41
GENTALOSE SYRUP 1 bottle / 500 ML syrup each (Biocon)$ 5.54
GENTALOSE oral liqd 10 g x 15 mL x 100ml (Biocon)$ 1.25
GENTALOSE oral liqd 10 g x 15 mL x 200ml (Biocon)$ 2.41
GENTALOSE oral liqd 10 g x 15 mL x 500ml (Biocon)$ 5.54
Syrup; Oral; Lactulose 0.67 g / ml (Gerard)
GEROLAC 10 GM SYRUP 1 bottle / 100 ML syrup each (Orchid Chemicals & Pharmaceuticals Ltd)$ 1.30
Gerolac 10gm Syrup (Orchid Chemicals & Pharmaceuticals Ltd)$ 1.30
Syrup; Oral; Lactulose 667 mg / ml
GUSH Liquid / 10gm per 15ml / 140ml units (Panacea Biotec Ltd)$ 1.25
Gush 10g/15mL SYR / 140ml (Panacea Biotec Ltd)$ 1.25
10 g x 15 mL x 140ml (Panacea Biotec Ltd)$ 1.25
Gush 140 ml Syrup (Panacea Biotec Ltd)$ 0.13
GUSH 10 GM/3.5 GM POWDER 1 box / 90 GM powder each (Panacea Biotec Ltd)$ 3.48
GUSH syr 10 g x 15 mL x 140ml (Panacea Biotec Ltd)$ 1.25
Gush 10g/15mL SYR / 140ml (Panacea Biotec Ltd)$ 1.25
Hapylac 200 ml Syrup (Shree Raj Pharmaceuticals)$ 0.18
Harilax 100 ml Suspension (Servocare Lifesciences)$ 0.05
Hepalac 66.7 % x 120 mL (Berlin Pharm)
Hepalac 66.7 % x 1 L (Berlin Pharm)
Hepalac syr 66.7 % 100 mL x 1's (Berlin Pharm)
Syrup; Oral; Lactulose (Medice)
Solution; Oral, Rectal; Lactulose 10 g / 15 ml (Copley)
HEPTULAC FIBER SOLUTION 1 bottle / 200 ML solution each (Cipla Ltd)$ 3.25

References

  1. DailyMed. "LACTULOSE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "lactulose". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "lactulose". http://www.drugbank.ca/drugs/DB00581 (accessed September 17, 2018).

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