Frumid Uses

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What is Frumid?

Frumid belongs to a group of medicines called loop diuretics (also known as water pills). Frumid is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine.

Frumid is also used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Frumid is available only with your doctor's prescription.

Frumid indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Parenteral therapy should be reserved for patients unable to take oral medication or for patients in emergency clinical situations.

Edema: Frumid is indicated in adults and pediatric patients for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Frumid is particularly useful when an agent with greater diuretic potential is desired.

Frumid is indicated as adjunctive therapy in acute pulmonary edema. The intravenous administration of Frumid is indicated when a rapid onset of diuresis is desired, e.g., in acute pulmonary edema.

If gastrointestinal absorption is impaired or oral medication is not practical for any reason, Frumid is indicated by the intravenous or intramuscular route.

Parenteral use should be replaced with oral Frumid as soon as practical.

How should I use Frumid?

Use Frumid solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Frumid solution.

Uses of Frumid in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Frumid is used to reduce extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, and kidney disease. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen.

This drug is also used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

Frumid is a "water pill" (diuretic) that causes you to make more urine. This helps your body get rid of extra water and salt.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to decrease a high level of calcium in the blood (hypercalcemia).

How to use Frumid

Read the Patient Information Leaflet if available from your pharmacist before you start taking Frumid and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, with or without food, usually once or twice daily. It is best to avoid taking this medication within 4 hours of your bedtime to prevent having to get up to urinate.

Dosage is based on your medical condition, age, and response to treatment. For children, the dose is also based on weight. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose or take it more often than directed.

Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) of the day as directed. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Sucralfate, cholestyramine, and colestipol can decrease the absorption of Frumid. If you are taking any of these drugs, separate the timing of each dose from Frumid by at least 2 hours.

Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings remain high or increase).

Frumid description

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A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Frumid has also been administered orally in the treatment of trypanosomiasis.

Frumid dosage

Frumid Dosage

Generic name: Frumid 20mg

Dosage form: tablet

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Edema

Therapy should be individualized according to patient response to gain maximal therapeutic response and to determine the minimal dose needed to maintain that response.

Adults -- The usual initial dose of Frumid is 20 to 80 mg given as a single dose. Ordinarily a prompt diuresis ensues. If needed, the same dose can be administered 6 to 8 hours later or the dose may be increased. The dose may be raised by 20 or 40 mg and given not sooner than 6 to 8 hours after the previous dose until the desired diuretic effect has been obtained. The individually determined single dose should then be given once or twice daily (eg, at 8 am and 2 pm). The dose of Frumid may be carefully titrated up to 600 mg/day in patients with clinically severe edematous states.

Edema may be most efficiently and safely mobilized by giving Frumid on 2 to 4 consecutive days each week.

When doses exceeding 80 mg/day are given for prolonged periods, careful clinical observation and laboratory monitoring are particularly advisable.

Geriatric patients -- In general, dose selection for the elderly patient should be cautious, usually starting at the low end of the dosing range.

Pediatric patients -- The usual initial dose of oral Frumid in pediatric patients is 2 mg/kg body weight, given as a single dose. If the diuretic response is not satisfactory after the initial dose, dosage may be increased by 1 or 2 mg/kg no sooner than 6 to 8 hours after the previous dose. Doses greater than 6 mg/kg body weight are not recommended. For maintenance therapy in pediatric patients, the dose should be adjusted to the minimum effective level.

Hypertension

Therapy should be individualized according to the patient’s response to gain maximal therapeutic response and to determine the minimal dose needed to maintain the therapeutic response.

Adults -- The usual initial dose of Frumid for hypertension is 80 mg, usually divided into 40 mg twice a day. Dosage should then be adjusted according to response. If response is not satisfactory, add other antihypertensive agents.

Changes in blood pressure must be carefully monitored when Frumid is used with other antihypertensive drugs, especially during initial therapy. To prevent excessive drop in blood pressure, the dosage of other agents should be reduced by at least 50% when Frumid is added to the regimen. As the blood pressure falls under the potentiating effect of Frumid, a further reduction in dosage or even discontinuation of other antihypertensive drugs may be necessary.

Geriatric patients -- In general, dose selection and dose adjustment for the elderly patient should be cautious, usually starting at the low end of the dosing range.

More about Frumid (Frumid)

Consumer resources

Professional resources

Related treatment guides

Frumid interactions

See also:
What other drugs will affect Frumid?

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Apo-Frumid may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function. Except in life-threatening situations, avoid this combination.

Apo-Frumid should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity. Patients receiving high doses of salicylates concomitantly with Frumid, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.

Apo-Frumid has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine.

Lithium generally should not be given with diuretics because they reduce lithiums renal clearance and add a high risk of lithium toxicity.

Apo-Frumid may add to or potentiate the therapeutic effect of other antihypertensive drugs. Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs.

Apo-Frumid may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still be used effectively.

Tablets

Simultaneous administration of sucralfate and Frumid tablets may reduce the natriuretic and antihypertensive effects of Frumid. Patients receiving both drugs should be observed closely to determine if the desired diuretic and/or antihypertensive effect of Frumid is achieved. The intake of Frumid and sucralfate should be separated by at least two hours.

Tablets, Injection, and

Oral Solution

One study in six subjects demonstrated that the combination of Frumid and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency. There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when Frumid was used in conjunction with NSAIDs.

Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of Frumid in some patients by inhibiting prostaglandin synthesis. Indomethacin may also affect plasma renin levels, aldosterone excretion, and renin profile evaluation. Patients receiving both indomethacin and Frumid should be observed closely to determine if the desired diuretic and/or antihypertensive effect of Frumid is achieved.

Frumid side effects

See also:
What are the possible side effects of Frumid?

Applies to Frumid: oral solution, oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by Frumid (the active ingredient contained in Frumid). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Frumid:

Rare

Incidence not known:

If any of the following symptoms of overdose occur while taking Frumid, get emergency help immediately:

Symptoms of overdose:

Minor Side Effects

Some of the side effects that can occur with Frumid may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:

Frumid contraindications

See also:
What is the most important information I should know about Frumid?

Hypersensitivity to Frumid or any component of the formulation; anuria

Canadian labeling: Additional contraindications (not in US labeling): Hypersensitivity to sulfonamide-derived drugs; complete renal shutdown; hepatic coma and precoma; uncorrected states of electrolyte depletion, hypovolemia, dehydration, or hypotension; jaundiced newborn infants or infants with disease(s) capable of causing hyperbilirubinemia and possibly kernicterus; breast-feeding. Note: Manufacturer labeling for Frumid Special and Frumid Special Injection also includes: GFR <5 mL/minute or GFR >20 mL/minute; hepatic cirrhosis; renal failure accompanied by hepatic coma and precoma; renal failure due to poisoning with nephrotoxic or hepatotoxic substances.

Note: Although the approved product labeling states this medication is contraindicated with other sulfonamide-containing drug classes, the scientific basis of this statement has been challenged. See “Warnings/Precautions” for more detail.



Active ingredient matches for Frumid:

Furosemide in Philippines.


Unit description / dosage (Manufacturer)Price, USD
Frumid / amp 10 mg/1 mL x 2 mL x 10's

List of Frumid substitutes (brand and generic names):

Frumide 40+5 Tablet (Gnosis Pharmaceuticals (P) Ltd)$ 0.02
FRUMIDE 40MG/5MG TABLET 1 strip / 10 tablets each (Gnosis Pharmaceuticals (P) Ltd)$ 0.09
Frumide 40 mg/5 mg Tablet (Gnosis Pharmaceuticals (P) Ltd)$ 0.01
FRUMIDE 40MG/5MG TABLET (Gnosis Pharmaceuticals (P) Ltd)$ 0.02
Tablet; Oral; Furosemide 40 mg (Hexal)
Tablets; Oral; Furosemide 40 mg (Hexal)
Injectable; Injection; Furosemide 10 mg / ml (Korea United Pharma)
Tablets; Oral; Furosemide 20 mg (Korea United Pharma)
Tablets; Oral; Furosemide 40 mg (Korea United Pharma)
Frusema 20 mg x 100's (Korea United Pharma)$ 0.13
Frusema 40 mg x 100's (Korea United Pharma)$ 0.23
Frusema / amp 20 mg/2 mL x 100's (Korea United Pharma)$ 144.76
Frusema tab 20 mg 100's (Korea United Pharma)
Frusema tab 40 mg 100's (Korea United Pharma)
Frusemide 40 mg x 1, 000's (Kokad Pharmaceutical Laboratories Ltd)
Frusemide 10 mg Injection (Kokad Pharmaceutical Laboratories Ltd)$ 0.05
Injectable; Injection; Furosemide 10 mg / ml
Injectable; Injection; Furosemide 10 mg / ml
FRUSEMIDE 40MG TABLET 1 strip / 10 tablets each (Jan Aushadhi)$ 0.07
Frusemide DHA 40 mg x 1000's (DHA)
Frusemide DHA tab 40 mg 10 x 10 x 10's (DHA)
Tablet; Oral; Furosemide 40 mg
Tablets; Oral; Furosemide 40 mg
Frusemide-Hameln 20 mg/2 mL x 2 mL x 10's (Hameln Pharma Plus)$ 90.00
Frusemide-Hameln inj 20 mg/2 mL 2 mL x 10 x 1's (Hameln Pharma Plus)
40 mg x 10's (Geno Pharmaceuticals Ltd.)$ 0.06
100 mg x 10's (Geno Pharmaceuticals Ltd.)$ 0.07
Tablets; Oral; Furosemide 40 mg (Geno Pharmaceuticals Ltd.)
Tablets; Oral; Furosemide 100 mg (Geno Pharmaceuticals Ltd.)

References

  1. DailyMed. "FUROSEMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "furosemide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "furosemide". http://www.drugbank.ca/drugs/DB00695 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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