Gardenal oral Pregnancy

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Pregnancy of Gardenal oral in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.

According to some reports the use of Gardenal oral as an anticonvulsant during pregnancy leads to disruption of blood clotting in a newborn and can cause bleeding in the early postpartum period (usually within the first 24 hours after birth).

If barbiturates are used during childbirth there are encouraged to take delivery in intensive care availability.

Barbiturates are excreted in breast milk. Receiving barbiturates by nursing mother may cause CNS depression in the infant.

Rhea Gardenal oral as an inducer of microsomal oxidation enzymes in the liver and increases its detoxifying function, reduces the concentration of bilirubin in serum. This property makes it appropriate use of Gardenal oral in hemolytic disease of the newborn.

Gardenal oral breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

Not recommended. Excreted into human milk: Yes Comments: -Breastfed infants should be monitored for sedation, weight gain, and developmental milestones, especially in younger infants who are exclusively breastfed or during concomitant use with psychotropic drug combinations. -If toxicity is a concern, infant serum concentration of this drug should be obtained.

Excretion of this drug into breastmilk is highly variable. Breastfed infants showed increased sedation and suckling difficulties compared to infants that were not exposed to this drug. Reports of infantile spasms and withdrawal symptoms in infants occurred after abrupt discontinuation. Since this drug is excreted in breastmilk, methemoglobinemia is another potential risk.

See references

References for pregnancy information

  1. "Product Information. Gardenal oral." Lilly, Eli and Company, Indianapolis, IN.
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

References for breastfeeding information

  1. "Product Information. Gardenal oral." Lilly, Eli and Company, Indianapolis, IN.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Cerner Multum, Inc. "Australian Product Information." O 0
  4. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL:" ([cited 2013 -]):



  1. PubMed Health. "Phenobarbital (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". (accessed September 17, 2018).
  2. Human Metabolome Database (HMDB). "Phenobarbital: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". (accessed September 17, 2018).
  3. LiverTox. "Phenobarbital: LIVERTOX provides up-to-date, accurate, and easily accessed information on the diagnosis, cause, frequency, patterns, and management of liver injury attributable to prescription and nonprescription medications, herbals and dietary supplements. ". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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