Gascol warnings
Low-phosphate diets: Aluminium hydroxide in patients with low-phosphate diets may lead to phosphate depletion accompanied by increased resorption and urinary excretion of calcium with the risk of osteomalacia.
Chronic renal failure: Osteomalacia, and also encephalopathy and dementia, have occurred in patients with chronic renal failure who received relatively high doses of aluminium hydroxide as a phosphate-binding agent. Hypermagnesemia has occurred after the excessive use of magnesium-containing antacids and especially in renal insufficiency. Symptoms may include flushing of the skin, thirst, hypotension due to peripheral vasodilatation, drowsiness, confusion, loss of tendon reflexes due to neuromuscular blockade, muscle weakness, respiratory depression, cardiac arrhythmias, coma, and cardiac arrest.
References
- DailyMed. "MAGNESIUM HYDROXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "Dimethicone - DrugBank". http://www.drugbank.ca/drugs/DB11074 (accessed September 17, 2018).
- DrugBank. "Magnesium Hydroxide". http://www.drugbank.ca/drugs/DB09104 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
