Gentamicin 80 Mg Actions

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Actions of Gentamicin 80 Mg in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Gentamicin 80 Mg is a broad-spectrum antibiotic of the aminoglycoside group. It is bactericidal by interfering with normal bacterial protein synthesis and has a sustained post-antibiotic effect against susceptible pathogens. The spectrum of action covers gram-negative and gram-positive organisms, among them so-called "problem germs" which are resistant to other antibiotics. In general, the following pathogens are highly susceptible: E. coli, Proteus, Shigella, Salmonella, Klebsiella, Aerobacter, Pseudomonas, Providencia, Haemophilus, gonococci as well as staphylococci including penicillin-resistant and penicillinase-producing strains.

Pharmacokinetics: Gentamicin 80 Mg is administered IM or IV.

Oral doses are not absorbed from the gut. The plasma elimination t½ is about 2 hrs. Gentamicin 80 Mg is not metabolized, but eliminated in a microbiologically active form along renal pathways, principally by glomerular filtration. The resident intestinal flora is unaffected.

How should I take Gentamicin 80 Mg?

For patients using the eye drop form of Gentamicin 80 Mg:

For patients using the eye ointment form of Gentamicin 80 Mg:

To help clear up your infection completely, keep using Gentamicin 80 Mg for the full time of treatment, even if your symptoms have disappeared. Do not miss any doses.

Dosing

The dose of Gentamicin 80 Mg will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Gentamicin 80 Mg. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed Dose

If you miss a dose of Gentamicin 80 Mg, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Gentamicin 80 Mg administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
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IM: Administer by deep IM route if possible.

IV: Infuse over 30 to 120 minutes.

Some penicillins (eg, carbenicillin, ticarcillin, and piperacillin) have been shown to inactivate aminoglycosides in vitro. This has been observed to a greater extent with tobramycin and Gentamicin 80 Mg, while amikacin has shown greater stability against inactivation. Concurrent use of these agents may pose a risk of reduced antibacterial efficacy in vivo, particularly in the setting of profound renal impairment. However, definitive clinical evidence is lacking. If combination penicillin/aminoglycoside therapy is desired in a patient with renal dysfunction, separation of doses (if feasible), and routine monitoring of aminoglycoside levels, CBC, and clinical response should be considered.

Intraventricular (off-label route): Use preservative-free preparations only. When administered through a ventricular drain, clamp drain for 15 to 60 minutes before opening the drain to allow Gentamicin 80 Mg solution to equilibrate in the cerebrospinal fluid (IDSA [Tunkel 2004]; IDSA [Tunkel 2017]).

Gentamicin 80 Mg pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.
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Gentamicin 80 Mg is a wide spectrum antibiotic that provides highly effective topical treatment in primary and secondary bacterial infections of the skin. Gentamicin 80 Mg Cream USP, 0.1% may clear infections that have not responded to other topical antibiotic agents. In primary skin infections such as impetigo contagiosa, treatment three or four times daily with Gentamicin 80 Mg Cream USP, 0.1% usually clears the lesions promptly. In secondary skin infections, Gentamicin 80 Mg Cream USP, 0.1% aids in the treatment of the underlying dermatosis by controlling the infection. Bacteria susceptible to the action of Gentamicin 80 Mg include sensitive strains of Streptococci (group A beta-hemolytic, alpha-hemolytic), Staphylococcus aureus (coagulase positive, coagulase negative, and some penicillinase-producing strains), and the gram-negative bacteria, Pseudomonas aeruginosa, Aerobacteraerogenes, Escherichia coli, Proteus vulgaris and Klebsiella pneumoniae.

References

  1. DailyMed. "GENTAMICIN SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. NCIt. "Gentamicin C1: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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