Gestopan Uses

Is this medication very expensive?

What is Gestopan?

Improving food digestion in patients who cannot digest food properly because they have a pancreas problem (exocrine pancreatic insufficiency) caused by cystic fibrosis or certain other conditions. It may also be used for other conditions as determined by your doctor.

Gestopan delayed-release capsules is a digestive enzyme combination. It works by helping the body to digest protein, starch, and fat.

Gestopan indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Gestopan (pancrelipase delayed-release minimicrospheres) Capsules are indicated for patients with pancreatic exocrine insufficiency as is often associated with:

  • cystic fibrosis
  • chronic pancreatitis
  • post-pancreatectomy
  • post-gastrointestinal bypass surgery (e.g., Billroth II gastroenterostomy)
  • ductal obstruction from neoplasm (e.g., of the pancreas or common bile duct)

How should I use Gestopan?

Use Gestopan delayed-release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Gestopan delayed-release capsules by mouth with each meal or snack as directed by your doctor. Do not take without food.
  • Swallow Gestopan delayed-release capsules whole with enough liquid to swallow it completely. Do not break, crush, chew, or hold Gestopan delayed-release capsules in your mouth before swallowing. Doing so may increase the risk of mouth or tongue irritation from Gestopan delayed-release capsules. Follow with a glass of water or juice. Contact your doctor if you experience mouth or tongue irritation while taking Gestopan delayed-release capsules.
  • If you cannot swallow the capsule whole, you may open it and sprinkle the contents over soft, bland food. Do NOT crush or chew the contents of the capsule. Ask your doctor or pharmacist if you have questions about what kind of food can be mixed with Gestopan delayed-release capsules.
  • If you mix the medicine with food, swallow the entire mixture right away. Do not save it for use at a later time. Drink a glass of water or juice after you swallow the mixture.
  • Continue to take Gestopan delayed-release capsules even if you feel well. Do not miss any doses.
  • If you miss a dose of Gestopan delayed-release capsules, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once or take a dose without a snack or a meal.

Ask your health care provider any questions you may have about how to use Gestopan delayed-release capsules.

Uses of Gestopan in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

This medication contains digestive enzymes to help break down and digest fats, starch, and proteins in food. It is used in conditions where the pancreas cannot make or does not release enough digestive enzymes into the small intestines to digest the food (e.g., chronic pancreatitis, cystic fibrosis, cancer of the pancreas, post-pancreatectomy, post-gastrointestinal bypass surgery).

How to use Gestopan

Some brands of this medication have a Medication Guide provided by your pharmacist. If one is available, read the Medication Guide before your start taking this medication and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth with meals and snacks as directed by your doctor. Swallow the capsule whole. Do not crush or chew the capsules or keep the capsules in your mouth. Doing so can irritate the mouth and also change the way the medication works.

If swallowing is difficult, then the capsule may be opened and the contents mixed in a small amount of liquid or soft food that does not need to be chewed (such as room-temperature applesauce). Do not mix the contents of the capsule with alkaline food or liquid (such as milk, ice cream, tea). Consult your doctor or pharmacist for more information about what foods/liquids (such as infant formula, breast milk) to avoid when mixing. Swallow the food or liquid right away, making sure not to chew the medication. Drink a glass of water or juice after swallowing the food to make sure all the medication is swallowed. Do not save the medication mixture for later.

Dosage is based on your medical condition, diet, weight, and response to treatment. Do not take more capsules in a day than prescribed by your doctor. Your condition will not improve any faster, and your risk of side effects will increase.

Drink plenty of fluids while taking this medication unless your doctor tells you otherwise.

Use this medication regularly to get the most benefit from it. Take it with every meal or snack.

If your doctor has recommended that you follow a special diet, it is very important to follow the diet to get the most benefit from this medication.

Do not change brands or dosage forms of pancrelipase without consulting your doctor or pharmacist. Different products may contain different amounts of the digestive enzymes.

Inform your doctor if your condition persists or worsens.

Gestopan description


Each minimicrospheres capsule contains pancreas powder 150 mg corresponding to Amylase (Gestopan) 8,000 Ph Eur units, Lipase (Gestopan) 10,000 Ph Eur units and Protease (Gestopan) 600 Ph Eur units produced from porcine pancreatic tissue.

Excipients/Inactive Ingredients: Pellet Core: Macrogol 4000.

Pellet Coating: Hypromellose phthalate, cetyl alcohol, triethyl citrate, dimethicone 1,000.

Capsule: Gelatin, iron oxide (E172), titanium dioxide (E171), sodium lauryl sulphate.

Gestopan dosage

Clinical experience should dictate initial starting dose. Doses should be taken during meals or snacks, not before or after. Do not take without food.

Adults and Children Over 6 Years Old

Usual initial starting dosage is two to four Gestopan (pancrelipase delayed-release minimicrospheres) Capsules per meal or snack.

Children Under 6 Years Old

The exact dosage of Gestopan (pancrelipase delayed-release minimicrospheres) Capsules should be selected based on clinical experience for this age group. Patients can be started on one to two capsules per meal or snack.

For cystic fibrosis patients, typical doses are 1,500 - 3,000 USP Lipase (Gestopan) units/kg/meal. Dosage should be adjusted according to the severity of the disease, control of steatorrhea and maintenance of good nutritional status. Doses in excess of 6,000 USP Lipase (Gestopan) units/kg/meal are not recommended.

Dose increases, if required, should occur with careful monitoring of body weight and stool fat content. When changing strengths of pancreatic enzyme products, care should be taken to maintain equivalent Lipase (Gestopan) units for each divided dosage.

It is important to ensure adequate hydration of patients at all times while taking pancreatic enzymes.

Where swallowing of capsules is difficult, the capsules may be carefully opened and the MINIMICROSPHERES added to a small amount of soft food, with a pH less than 5.5. The soft food should be swallowed immediately without chewing and followed with a glass of water or juice to insure swallowing.

How supplied

Gestopan MINIMICROSPHERES (Pancrelipase Delayed-release Capsules, USP) are available in a two-piece gelatin capsule (orange opaque top half, blue opaque bottom half) imprinted in white with "SOLVAY" and "1205". Each capsule contains tan-colored delayed-release MINIMICROSPHERES of pancrelipase supplied in bottles of:

100.......NDC 0032-1205-01

250.......NDC 0032-1205-07

Gestopan (pancrelipase delayed-release minimicrospheres) Capsules must be stored at 25

Gestopan interactions

See also:
What other drugs will affect Gestopan?


Antacids should not be taken concomitantly with Gestopan as the alkaline pH may destroy the enteric-coating.

Gestopan side effects

See also:
What are the possible side effects of Gestopan?

Applies to pancrelipase: oral capsule, oral capsule delayed release, oral powder, oral tablet, oral tablet chewable

As well as its needed effects, pancrelipase may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking pancrelipase, check with your doctor immediately:


  • Skin rash or hives
With high doses
  • Bowel blockage
  • diarrhea
  • nausea
  • stomach cramps or pain
With very high doses
  • Blood in the urine
  • joint pain
  • swelling of the feet or lower legs
With powder dosage form or powder from opened capsules - if breathed in
  • Shortness of breath
  • stuffy nose
  • tightness in the chest
  • trouble breathing
With tablets - if held in mouth
  • Irritation of the mouth
Incidence not known:
  • Cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • itching
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • severe stomach pain
  • unusual tiredness or weakness

Minor Side Effects

Some pancrelipase side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

  • Blurred vision
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • sweating
  • unexplained weight loss
  • vomiting
Less common:
  • Abnormal feces
  • anxiety
  • bloated
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • depression
  • excess air or gas in the stomach or intestines
  • fever
  • frequent bowel movements
  • full feeling
  • muscle aches
  • nightmares
  • passing gas
  • runny nose
  • seizures
  • shakiness
  • slurred speech
  • sore throat
Incidence not known:
  • Difficulty having a bowel movement (stool)
  • difficulty with moving
  • muscle aching or cramping
  • muscle pains or stiffness
  • muscle spasm
  • swollen joints

Gestopan contraindications

See also:
What is the most important information I should know about Gestopan?

you are allergic to any ingredient in Gestopan Delayed-Release Capsules or to pork protein.

you have inflammation of the pancreas (pancreatitis) or a flare-up of long-term pancreas problems.

Active ingredient matches for Gestopan:

Amylase/lipase/protease in Vietnam.

Unit description / dosage (Manufacturer)Price, USD
Gestopan 10 Blister x 10 Tablet

List of Gestopan substitutes (brand and generic names):

Capsule; Oral; Amylase 8000 IU; Lipase 10, 000 units; Protease 600 IU
Capsule; Oral; Amylase 18, 000 IU; Lipase 25, 000 units; Protease 1000 IU
Capsule; Oral; Amylase 25, 000 IU; Lipase 40, 000 units; Protease 1600 IU
Capsule; Oral; Lipase 30, 000 units; Protease 8, 000 units; Amylase 30, 000 units
Panlipase Cap Lipase 25000 u, protease 62500u, amylase 74700 u. CAP / 10 (Sun (Solares))$ 5.71
PANLIPASE CAP cap 10's (Sun (Solares))$ 5.71
Tablet, Enteric Coated; Oral; Amylase 12, 000 IU; Lipase 20, 000 units; Protease 900 IU
Protase 100 x 10's
Protase 10 Blister x 10 Tablet
Tablet; Oral; Amylase 110 units; Lipase 18 units; Protease 95 units
Sancase 100 Tablet


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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