Glucosamine Actions

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Actions of Glucosamine in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Glucosamine contains a unique combination of chondroitin and Glucosamine to help maintain healthy joints.

Glucosamine Sulphate: A special ingredient to help keep joints in good shape. Glucosamine is naturally required by the body for the production of collagen to cushion the joints (cartilage) and synovial fluid which bathes and lubricates them. It is present in the formulation in the preferred potassium form, with minerals for improved absorption.

Ginger Extract: A spice commonly associated with joint health.

Chondroitin Sulphate: Helps form the proteins that maintain cartilage elasticity and works synergistically with Glucosamine to help maintain joint health. Glucosamine contains a high quality low molecular weight (LMW) form of chondroitin.

Trace Minerals and Vitamins: Including antioxidant vitamins C, E, and D to help maintain strong bones.

Pharmacology: Tablet: Glucosamine Sulfate: Glucosamine is essential for normal glycosaminoglycan synthesis, which begins with the synthesis of a core protein pool that is transported to specialized compartments within secretory cells eg, cartilage cells. Next, sugar residues, including glucosamines, are added to the core protein, followed by the rapid addition of an extremely large number of long glycosaminoglycan chains. The addition of sulfur to the aminosugar residues occurs almost simultaneously in cartilage cells and in cells from which connective tissue is developed (fibroblasts). Thus, one hypothesis for enhanced cartilage repair is to provide sufficient Glucosamine to ensure rapid synthesis of glycosaminoglycans. Enhanced synthesis of glycosaminoglycans and proteoglycans may then be able to overcome the degradation that occurs during joint disease and after injury.

It has been suggested that the health benefit of oral Glucosamine in osteoarthritis, a disease characterized by a net loss of joint cartilage and an increase in the amount of enzymes that break down proteoglycans may be due to increased synthesis of cartilage proteoglycans.

Chondroitin Sulfate: Chondroitin increases the ability of joint cartilage to retain water and cushions the joint, improving both lubrication and nourishment of the joint cartilage. Chondroitin sulfate, like Glucosamine sulfate, stimulates the chondrocytes to produce more of the building blocks of collagen and the cartilage matrix.

Chondroitin supplementation modulates the balance between catabolism and anabolism in joint tissues and tips the scales toward repair by inhibiting the actions of the enzyme-destroying cartilage. At the same time, chondroitin sulfate also alters the cellular environment to promote nourishment and holds at bay other enzymes that would reduce nutrient transport to the cartilage. The overall impact of chondroitin sulfate supplementation complements the effects of Glucosamine supplementation.

Gel: Lipophilic Glucosamine and chondroitin can pass through the impermeable lipid layer under the skin. Then, lipophilic Glucosamine and chondroitin directly enter the local circulation and are transported throughout the targeted joint after half an hour of applying Glucosamine gel. The fragrance of aroma-active oils can relax the brain and reduce pain threshold.

How should I take Glucosamine?

When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.

If you choose to use Glucosamine, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.

Do not use different formulations of Glucosamine at the same time without medical advice. Using different formulations together increases the risk of an overdose of Glucosamine.

This medicine can cause unusual results with a blood glucose (sugar) test. Do not use this product without a doctor's advice if you are diabetic.

If you need surgery, tell the surgeon ahead of time that you are using Glucosamine. You may need to stop using the medicine for a short time.

It may take up to 8 weeks before your symptoms improve. For best results, keep using Glucosamine as directed.

Call your doctor if your symptoms do not improve, or if they get worse while using Glucosamine.

Store at room temperature away from moisture and heat.

Glucosamine administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
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Should be taken with food. Preferably taken at meals.

Glucosamine pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.

Osteoarthritis is characterized by the progressive degeneration of cartilage glycosaminoglycans. The formation of Glucosamine is the rate limiting step in glycosaminoglycans synthesis thus the addition is Glucosamine, would in theory provide a building block towards the synthesis of glycosaminoglycans and thus slow down the progression of osteoarthritis. Thus far however, the results have not been conclusive.

Reviews

The results of a survey conducted on ndrugs.com for Glucosamine are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Glucosamine. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported administration

When best can I take Glucosamine, on an empty stomach, before or after food?
ndrugs.com website users have also released a report stating that Glucosamine should be taken With a meal. In any case, this may not be the right description on how you ought to take this Glucosamine. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Glucosamine can be taken.
Users%
With a meal1
100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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