Glucosamine Overdose

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What happens if I overdose Glucosamine?

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately.

Proper storage of Glucosamine:

Store at room temperature away from heat, moisture, and light unless otherwise directed on the package label. Do not store in the bathroom. Most dietary supplements are not in childproof containers. Keep Glucosamine out of the reach of children and away from pets.

Overdose of Glucosamine in details

When a dose is taken in higher dose than the recommended doses, it is called Overdose. Overdose always needs a clinical supervision. Any medicine or drug when consumed in Overdose produces untoward side effects on one or various organs in the body. A medicine is excreted in the kidney or metabolized in the liver most of the times. This process goes without any hurdles when taken in normal dose, but when taken in an overdose, the body is not able to metabolize it or send it out properly which causes the effects of anoverdose.
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No cases of accidental or intentional overdose are known. The acute animal and chronic toxicological studies of Glucosamine active ingredients indicate that toxic effects and symptoms of toxicity are not likely to occur, even after high overdoses.

However, if overdose occur the treatment should be symptomatic eg, hydroelectrolytic balance restoration.

What should I avoid while taking Glucosamine?

Some Glucosamine products also contain manganese. Taking too much of this combination can cause a manganese overdose. Do not take more than directed on the medicine label.

Glucosamine warnings

Warnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.

History of GI ulceration; impaired cardiac, renal or hepatic function; hypertension; lactation. IV admin in patients with moderate or severe renal impairment; hypovolaemia or dehydration; asthma, porphyria. Monitor LFTs in patients on prolonged therapy. May prolong bleeding time; caution when used in patients with coagulation disorders or on anticoagulants. Prolonged therapy may increase risk of anaemia. 1st and 2nd trimester of pregnancy. Elderly, debilitated patients.

pregnancy:

Category B(Parenteral): Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Category C(Ophth /

Topical): Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

What should I discuss with my healthcare provider before taking Glucosamine?

You should not use this product if you are allergic to Glucosamine.

Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have:

It is not known whether Glucosamine will harm an unborn baby. Do not use this product without medical advice if you are pregnant.

Glucosamine may pass into breast milk and may harm a nursing baby. Do not use this product without medical advice if you are breast-feeding a baby.

Do not give any herbal/health supplement to a child without medical advice.

Glucosamine precautions

Certain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.
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Glucosamine is not indicated for the treatment of acute painful symptoms.

Glucosamine contains sodium and needs to be taken into consideration by patients on a controlled sodium diet.

In patients with cardiac and/or renal insufficiency, edema and water retention was observed very rarely.

This effect could be attributed to the effect of chondroitin sulphate. The administration of Glucosamine to these patients should be under strict medical supervision.

No special studies were performed in patients with hepatic insufficiency. The administration of Glucosamine to patients with severe hepatic insufficiency should be under strict medical supervision.

Caution is advised in treatment of patients with impaired glucose tolerance. Closer monitoring of blood sugar levels may be necessary at the beginning of treatment.

An increased effect of coumarinic anticoagulants (eg, warfarin) during concomitant consumption of Glucosamine sulphate, one of the active ingredients of Glucosamine, may occur. Therefore, a closer monitoring of the coagulation parameters may be considered in those patients being treated with Glucosamine.

Due to its chondroitin sulphate content, in case of concomitant administration of platelet antiaggregant drugs eg, acetylsalicylic acid, dipyridamole, clopidogrel, ditazol, trifusal and ticlopidine, Glucosamine should be administered under strict medical supervision.

Concurrent consumption of Glucosamine sulphate may increase the gastrointestinal absorption of tetracyclines. Caution is advised in case of concomitant administration of Glucosamine and tetracyclines.

The colouring agent sunset yellow (E110) may cause allergic reactions.

Effects on the Ability to Drive or Operate Machinery: No important effects on the central nervous system or motor system are known that might impair the ability to drive or use machines. However, caution is advised if somnolence or visual disturbances are experienced.

Use in pregnancy & lactation: In the absence of studies on reproductive function in humans, the use of Glucosamine during pregnancy and lactation should be avoided.

What happens if I miss a dose of Glucosamine?

When you miss a dose, you should take it as soon as you remember, but you should take care that it should be well spaced from the next dose. You should not take an extra dose at the time of the second dose as it will become a double dose. The double dose can give unwanted side effects, so be careful. In chronic conditions or when you have a serious health issue, if you miss a dose, you should inform your health care provider and ask his suggestion.

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra Glucosamine to make up the missed dose.


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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