Consists of Ethinyl Estradiol, Gestodene
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Gynovin CD Actions |
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Consists of Ethinyl Estradiol, Gestodene
Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
Ethinyl Estradiol (Gynovin CD) is a synthetic derivative of the natural estrogen estradiol. It is one of two estrogens currently used in oral contraceptive pills. The other, mestranol, is converted to Ethinyl Estradiol (Gynovin CD) before it is biologically active. Ethinyl Estradiol (Gynovin CD) and norethindrone are used together as an oral contraceptive agent.
Description: Gestodene (Gynovin CD) is a progestogen that is structurally related to levonorgestrel.
Pharmacokinetics:
Absorption: Well absorbed with a high bioavailability after oral admin.
Distribution: Extensively bound to plasma proteins (75-87% to sex hormone binding globulin, and 13-24% to albumin).
Metabolism: Hepatically metabolised.
Excretion: <1% excreted unchanged in the urine.
May be taken with or without food.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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