Hapacol Actions

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Actions of Hapacol in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.

Pharmacology: Pain is a very common experience and analgesic drugs such as Hapacol plays an important role in providing general pain relief for both acute and chronic pain. Hapacol is widely recommended as the initial drug of choice for the treatment of mild to moderate musculoskeletal pain and symptomatic osteoarthritis as it is regarded as having a more acceptable safety profile in chronic use than nonsteroidal anti-inflammatory drugs (NSAIDs).

Hapacol provides analgesic action via its inhibition activity on the central prostaglandin synthetase and its antipyretic action is thought to be due to selective inhibition of prostaglandin synthesis in the central nervous system (CNS).

Hapacol is readily absorbed from the upper small intestine, has absolute oral bioavailability (70-90%) and is extensively metabolized in the liver.

Pharmacokinetics: Hapacol formulation consists of a bilayer tablet containing 665 mg of Hapacol: One layer containing an immediate-release (IR) formulation and providing 31% of the total dose and a 2nd layer containing a sustained release (SR) formulation that provides the remaining 69% of the total dose.

Pharmacokinetics of Hapacol have been investigated in 2 pivotal biostudies. In the First study, Hapacol and Panadol tablets were compared in fed and fasted volunteers. Both were bioequivalent with respect to dose-corrected AUC(0-t) and AUC(0-inf) in both fed and fasted states. The bioavailability of Hapacol from Hapacol is not affected by food thus indicating that the formulation can be taken with or without food.

In the Second study, where Hapacol was again compared with Panadol; Hapacol showed a clear pattern of controlled release of Hapacol, and the formulations were bioequivalent based on the comparison of AUCs for the final 24 hours of the 48-hour dosing period. This shows that there is no additional accumulation of Hapacol from the Hapacol formulation. Besides that, steadier concentrations of Hapacol were achieved with Hapacol. Thus, Hapacol may be particularly appropriate for patients who require repeat doses as it maintains a continuous therapeutic effect when taken every 8 hours (2 x 665 mg tablets per dose).

How should I take Hapacol?

This section provides information on the proper use of a number of products that contain acetaminophen. It may not be specific to Hapacol. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Liver damage can occur if large amounts of acetaminophen are taken for a long time.

If you are taking this medicine without the advice of your doctor, carefully read the package label and follow the dosing instructions. Talk to your doctor if you have any questions.

Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours), as this may increase the risk for serious liver problems. For Tylenol® Extra Strength, the maximum dose is 3,000 milligrams per 24 hours.

You may take this medicine with or without food.

For patients using the oral liquid with syringe (e.g. Little Fevers®):

  • Shake the bottle well before each use.
  • Measure the dose with the provided dose syringe (e.g., AccuSafe™) that comes with the package. Do not use any other syringe, dropper, spoon, or dosing device when giving this medicine to your child.
  • Remove the cap, attach the syringe to the flow restrictor, and invert the bottle.
  • Pull back the syringe until filled with the dose prescribed by your doctor.
  • Slowly give the medicine into your child's mouth (towards the inner cheek).
  • Replace and tighten the cap.

For patients using the oral liquid with dropper:

  • Shake the bottle well before each use.
  • Measure the dose with the provided dropper. Do not use any other syringe, dropper, spoon, or dosing device when giving this medicine to your child.
  • Remove the cap, insert the dropper and withdraw the dose prescribed by your doctor.
  • Slowly give the medicine into your child's mouth (towards the inner cheek).
  • Replace the cap back tightly.

For patients using acetaminophen oral granules (e.g., Snaplets-FR):

  • Just before the medicine is to be taken, open the number of packets needed for one dose.
  • Mix the granules inside of the packets with a small amount of soft food, such as applesauce, ice cream, or jam.
  • Eat the acetaminophen granules along with the food.

For patients using acetaminophen oral powders (e.g., Hapacol® Sprinkle Caps [Children's or Junior Strength]):

  • These capsules are not intended to be swallowed whole. Instead, just before the medicine is to be taken, open the number of capsules needed for one dose.
  • Empty the powder from each capsule into 1 teaspoonful (5 mL) of water or other liquid.
  • Drink the medicine along with the liquid. You may drink more liquid after taking the medicine.
  • You may also mix the powder with a small amount of soft food, such as applesauce, ice cream, or jam. Eat the acetaminophen powder along with the food.

For patients using acetaminophen suppositories:

  • If the suppository is too soft to insert, chill it in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper.
  • To insert the suppository:
    • Remove the foil wrapper and moisten the suppository with cold water.
    • Lie down on your side and use your finger to push the suppository up into the rectum.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For pain or fever:
    • For oral and rectal dosage forms (capsules, granules, powders, solution, suppositories, suspension, or tablets):
      • Adults and teenagers—650 to 1000 milligrams (mg) every 4 to 6 hours as needed. Dose is based on form and strength. Carefully follow the label instructions for the maximum dose per day.
      • Children—Dose is based on weight or age. Carefully follow the label instructions for the maximum dose per day.
        • Children 11 to 12 years of age: 320 to 480 mg every 4 to 6 hours as needed.
        • Children 9 to 11 years of age: 320 to 400 mg every 4 to 6 hours as needed.
        • Children 6 to 9 years of age: 320 mg every 4 to 6 hours as needed.
        • Children 4 to 6 years of age: 240 mg every 4 to 6 hours as needed.
        • Children 2 to 4 years of age: 160 mg every 4 to 6 hours as needed.
        • Children under 2 years of age: Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the bottle closed when you are not using it. Store it at room temperature, away from light and heat. Do not freeze.

You may store the suppositories in the refrigerator, but do not freeze them.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Hapacol administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.

May be taken with or without food.

Hapacol pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.

The analgesic, antipyretic, and anti-inflammatory effects of aspirin are due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite. Hapacol directly and irreversibly inhibits the activity of both types of cyclo-oxygenase (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. This makes aspirin different from other NSAIDS (such as diclofenac and ibuprofen) which are reversible inhibitors. Salicylate may competitively inhibit prostaglandin formation. Hapacol's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms; the therapeutic effects are not due to pituitary-adrenal stimulation. The platelet aggregation–inhibiting effect of aspirin specifically involves the compound's ability to act as an acetyl donor to the platelet membrane; the nonacetylated salicylates have no clinically significant effect on platelet aggregation. Hapacol affects platelet function by inhibiting the enzyme prostaglandin cyclooxygenase in platelets, thereby preventing the formation of the aggregating agent thromboxane A2. This action is irreversible; the effects persist for the life of the platelets exposed. Hapacol may also inhibit formation of the platelet aggregation inhibitor prostacyclin (prostaglandin I2) in blood vessels; however, this action is reversible.



The results of a survey conducted on ndrugs.com for Hapacol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hapacol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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