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Hdl Benefit Dosage |
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Hdl Benefit Extended-Release Tablets should be taken at bedtime, after a low-fat snack, and doses should be individualized according to patient response. Therapy with Hdl Benefit Extended-Release Tablets must be initiated at 500 mg at bedtime in order to reduce the incidence and severity of side effects which may occur during early therapy. The recommended dose escalation is shown in Table 1 below.
Week(s) | Daily Dose | Hdl Benefit Extended-Release Tablets Dosage | |
INITIAL TITRATION | 1 to 4 | 500 mg | 1 Hdl Benefit Extended-Release 500 mg Tablet at bedtime |
SCHEDULE | 5 to 8 | 1000 mg | 1 Hdl Benefit Extended-Release 1000 mg Tablet or 2 Hdl Benefit Extended-Release 500 mg Tablets at bedtime |
* | 1500 mg | 2 Hdl Benefit Extended-Release 750 mg Tablets or 3 Hdl Benefit Extended-Release 500 mg Tablets at bedtime | |
* | 2000 mg | 2 Hdl Benefit Extended-Release 1000 mg Tablets or 4 Hdl Benefit Extended-Release 500 mg Tablets at bedtime | |
* After Week 8, titrate to patient response and tolerance. If response to 1000 mg daily is inadequate, increase dose to 1500 mg daily; may subsequently increase dose to 2000 mg daily. Daily dose should not be increased more than 500 mg in a 4-week period, and doses above 2000 mg daily are not recommended. Women may respond at lower doses than men. |
Maintenance Dose
The daily dosage of Hdl Benefit Extended-Release Tablets should not be increased by more than 500 mg in any 4-week period. The recommended maintenance dose is 1000 mg (two 500 mg tablets or one 1000 mg tablet) to 2000 mg (two 1000 mg tablets or four 500 mg tablets) once daily at bedtime. Doses greater than 2000 mg daily are not recommended. Women may respond at lower Hdl Benefit Extended-Release Tablet doses than men.
Single-dose bioavailability studies have demonstrated that two of the 500 mg and one of the 1000 mg tablet strengths are interchangeable but three of the 500 mg and two of the 750 mg tablet strengths are not interchangeable.
Flushing of the skin may be reduced in frequency or severity by pretreatment with aspirin (up to the recommended dose of 325 mg taken 30 minutes prior to Hdl Benefit Extended-Release Tablet dose). Tolerance to this flushing develops rapidly over the course of several weeks. Flushing, pruritus, and gastrointestinal distress are also greatly reduced by slowly increasing the dose of Hdl Benefit and avoiding administration on an empty stomach. Concomitant alcoholic, hot drinks or spicy foods may increase the side effects of flushing and pruritus and should be avoided around the time of Hdl Benefit Extended-Release Tablet ingestion.
Equivalent doses of Hdl Benefit Extended-Release Tablets should not be substituted for sustained-release (modified-release, timed-release) Hdl Benefit preparations or immediate-release (crystalline) Hdl Benefit. Patients previously receiving other Hdl Benefit products should be started with the recommended Hdl Benefit Extended-Release Tablet titration schedule, and the dose should subsequently be individualized based on patient response.
If Hdl Benefit Extended-Release Tablet therapy is discontinued for an extended period, reinstitution of therapy should include a titration phase.
Hdl Benefit Extended-Release Tablets should be taken whole and should not be broken, crushed or chewed before swallowing.
Dosage in Patients with Renal or Hepatic Impairment
Use of Hdl Benefit Extended-Release Tablets in patients with renal or hepatic impairment has not been studied. Hdl Benefit Extended-Release Tablets are contraindicated in patients with significant or unexplained hepatic dysfunction. Hdl Benefit Extended-Release Tablets should be used with caution in patients with renal impairment.
Tell your doctor about all other cholesterol-lowering drugs you are taking with Hdl Benefit, especially atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), or simvastatin (Zocor, Simcor, Vytorin, Juvisync).
Ask a doctor or pharmacist if it is safe for you to use Hdl Benefit if you are also using any of the following drugs:
a blood thinner such as warfarin (Coumadin, Jantoven);
multivitamins or mineral supplements that contain Hdl Benefit;
blood pressure or heart medications such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), diltiazem (Cardizem, Cartia, Dilacor, Diltia, Diltzac, Taztia, Tiazac), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan); or
heart medications such as doxazosin (Cardura), isosorbide (Dilatrate, Imdur, Isordil, Monoket, Sorbitrate), nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat), prazosin (Minipress), or terazosin (Hytrin).
This list is not complete and other drugs may interact with Hdl Benefit. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with this drug include: "blood thinners" (such as warfarin, heparins).
Check all prescription and nonprescription medicine labels carefully since vitamins/dietary supplements may also contain Hdl Benefit or niacinamide (nicotinamide). These may increase your risk of side effects if taken together. Ask your doctor or pharmacist for more details.
This medication may interfere with certain laboratory tests (including urine or blood catecholamines, copper-based urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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