Pregnancy of Hemotran in details
Hemotran crosses the placenta; concentrations within cord blood are similar to maternal serum.
Use of oral Hemotran for the long-term prophylaxis of HAE in pregnant females has been reported (González-Quevedo 2016; Machado 2017; Milingos 2009). Hemotran may be considered for long-term prophylaxis when preferred treatment is not available (WAO/EEACI [Maurer 2018]).
Intravenous Hemotran has been evaluated for the treatment of postpartum hemorrhage (Ducloy-Bouthors 2011; WOMAN Trial Collaborators 2017). A significant reduction in risk of death due to bleeding was observed when treatment was started within 3 hours of vaginal birth or cesarean section (WOMAN Trial Collaborators 2017). Hemotran is recommended for the treatment of obstetric hemorrhage when initial therapy fails (ACOG 183 2017; WHO 2017). IV Hemotran has also been studied for prophylaxis of postpartum hemorrhage in low-risk females prior to vaginal or cesarean delivery (Novikova 2015; Sentilhes 2018; Simonazzi 2016). However, available data related to prophylactic use is insufficient and use for routine prophylaxis against postpartum hemorrhage is not currently recommended outside of the context of clinical research (ACOG 183 2017).
Hemotran breastfeeding
Hemotran should be used during lactation only if clearly needed. Excreted into human milk: Yes Excreted into animal milk: Data not available The effects in the nursing infant are unknown.
Hemotran is excreted into human milk at a concentration of about one hundredth of the corresponding serum concentrations.
See references
References for pregnancy information
- "Product Information. LYSTEDA (Hemotran)." Xanodyne Pharmaceuticals Inc, Newport, KY.
- "Product Information. Cyklokapron (Hemotran)." Pharmacia and Upjohn, Kalamazoo, MI.
References for breastfeeding information
- "Product Information. Cyklokapron (Hemotran)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. LYSTEDA (Hemotran)." Xanodyne Pharmaceuticals Inc, Newport, KY.
References
- DailyMed. "TRANEXAMIC ACID: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Tranexamic Acid (By injection): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
