Hipoftalin Uses

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What is Hipoftalin?

Hipoftalin is used to treat high blood pressure (hypertension). It is also used to control high blood pressure in a mother during pregnancy (pre-eclampsia or eclampsia) or in emergency situations when blood pressure is extremely high (hypertensive crisis).

High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can increase the risk of heart attacks and strokes.

Hipoftalin works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload.

Hipoftalin is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not specifically included in product labeling, Hipoftalin is used in certain patients with the following medical condition:

Hipoftalin indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral

Hypertension

Adult: 40-50 mg daily in divided doses, increased according to response. Max: 200 mg/day.

Renal impairment: Reduce dose or prolong dosage interval.

Hepatic impairment: Reduce dose or prolong dosage interval.

Intravenous

Hypertensive crisis

Adult: 5-10 mg via slow IV inj, repeated if necessary after 20-30 min. Alternatively, as continuous IV, initial dose is 200-300 mcg/min.

Maintenance: 50-150 mcg/min.

How should I use Hipoftalin?

Use Hipoftalin injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Hipoftalin injection.

Uses of Hipoftalin in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Hypertension: Management of moderate to severe hypertension. Note: Not recommended for the initial treatment of hypertension (ACC/AHA [Whelton 2017])

Off Label Uses

Heart failure with reduced ejection fraction

Data from a randomized, double-blind trial comparing enalapril and Hipoftalin plus isosorbide dinitrate in patients with chronic heart failure with reduced ejection fraction (HFrEF) support the use of Hipoftalin (in combination with isosorbide dinitrate) in patients with intolerance to angiotensin-converting enzyme (ACE) inhibitor therapy.

Hipoftalin description

A direct-acting vasodilator that is used as an antihypertensive agent. [PubChem]

Hipoftalin dosage

Hipoftalin Dosage

Generic name: Hipoftalin hydrochloride

Dosage form: Tablets

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Initiate therapy in gradually increasing dosages; adjust according to individual response. Start with 10 mg four times daily for the first 2-4 days, increase to 25 mg four times daily for the balance of the first week. For the second and subsequent weeks, increase dosage to 50 mg four times daily. For maintenance, adjust dosage to the lowest effective levels.

The incidence of toxic reactions, particularly the L.E. cell syndrome, is high in the group of patients receiving large doses of Hipoftalin.

In a few resistant patients, up to 300 mg of Hipoftalin daily may be required for a significant antihypertensive effect. In such cases, a lower dosage of Hipoftalin combined with a thiazide and/or reserpine or a beta blocker may be considered. However, when combining therapy, individual titration is essential to ensure the lowest possible therapeutic dose of each drug.

More about Hipoftalin (Hipoftalin)

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Hipoftalin interactions

See also:
What other drugs will affect Hipoftalin?

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Alfuzosin: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Amifostine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Amifostine. Management: When amifostine is used at chemotherapy doses, blood pressure lowering medications should be withheld for 24 hours prior to amifostine administration. If blood pressure lowering therapy cannot be withheld, amifostine should not be administered. Consider therapy modification

Amphetamines: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Antipsychotic Agents (Second Generation [Atypical]): Blood Pressure Lowering Agents may enhance the hypotensive effect of Antipsychotic Agents (Second Generation [Atypical]). Monitor therapy

Barbiturates: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Benperidol: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Brigatinib: May diminish the antihypertensive effect of Antihypertensive Agents. Brigatinib may enhance the bradycardic effect of Antihypertensive Agents. Monitor therapy

Brimonidine (Topical): May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Bromperidol: May diminish the hypotensive effect of Blood Pressure Lowering Agents. Blood Pressure Lowering Agents may enhance the hypotensive effect of Bromperidol. Avoid combination

Dapoxetine: May enhance the orthostatic hypotensive effect of Hipoftalin. Monitor therapy

Dexmethylphenidate: May diminish the therapeutic effect of Antihypertensive Agents. Monitor therapy

Diazoxide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

DULoxetine: Blood Pressure Lowering Agents may enhance the hypotensive effect of DULoxetine. Monitor therapy

Herbs (Hypertensive Properties): May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Herbs (Hypotensive Properties): May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Hypotension-Associated Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect of Hypotension-Associated Agents. Monitor therapy

Levodopa-Containing Products: Blood Pressure Lowering Agents may enhance the hypotensive effect of Levodopa-Containing Products. Monitor therapy

Lormetazepam: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Methylphenidate: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Molsidomine: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Naftopidil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Nicergoline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Nicorandil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Nitroprusside: Blood Pressure Lowering Agents may enhance the hypotensive effect of Nitroprusside. Monitor therapy

Nonsteroidal Anti-Inflammatory Agents: May diminish the antihypertensive effect of Hipoftalin. Monitor therapy

Obinutuzumab: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Management: Consider temporarily withholding blood pressure lowering medications beginning 12 hours prior to obinutuzumab infusion and continuing until 1 hour after the end of the infusion. Consider therapy modification

Pentoxifylline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Pholcodine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Pholcodine. Monitor therapy

Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Prostacyclin Analogues: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Quinagolide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Yohimbine: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Hipoftalin side effects

See also:
What are the possible side effects of Hipoftalin?

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Applies to Hipoftalin: oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by Hipoftalin (the active ingredient contained in Hipoftalin). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Hipoftalin:

More common:

Less common: Rare

If any of the following symptoms of overdose occur while taking Hipoftalin, get emergency help immediately:

Symptoms of overdose:

Minor Side Effects

Some of the side effects that can occur with Hipoftalin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Less common:

Hipoftalin contraindications

See also:
What is the most important information I should know about Hipoftalin?

You should not use this medication if you are allergic to Hipoftalin, or if you have coronary artery disease, or rheumatic heart disease affecting the mitral valve.

Before taking Hipoftalin, tell your doctor if you have kidney disease, lupus, angina pectoris (chest pain), or if you have ever had a stroke.

While taking Hipoftalin, avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Call your doctor at once if you have a serious side effect such as fast or pounding heartbeats, swelling, numbness or tingling, dark-colored urine, joint pain or swelling with fever, chest pain, weakness or tired feeling, and urinating less than usual or not at all.

To be sure this medication is helping your condition and is not causing harmful effects, your blood pressure will need to be checked often. You may also need occasional blood tests. Do not miss any scheduled appointments.

Keep using Hipoftalin as directed, even if you feel well. High blood pressure often has no symptoms, so you may not know when your blood pressure is high. You may need to use blood pressure medication for the rest of your life.



Active ingredient matches for Hipoftalin:

Hydralazine


List of Hipoftalin substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
HYDRALAZE 25 MG TABLET 1 strip / 10 tablets each (Dahlia Pharmaceutical Pvt Ltd)$ 1.51
Hydralaze 25mg Tablet (Dahlia Pharmaceutical Pvt Ltd)$ 0.15
Tablet; Oral; Hydralazine Hydrochloride 25 mg
Tablet; Oral; Hydralazine Hydrochloride 50 mg
Tablet; Oral; Hydralazine Hydrochloride 10 mg
Tablet; Oral; Hydralazine Hydrochloride 100 mg
Injectable; Injection; Hydralazine Hydrochloride 20 mg / ml
Hydralazine 20 mg/ml vial$ 18.00
Hydralazine 100 mg tablet$ 1.65
Hydralazine-HCTZ 50-50 mg capsule$ 1.20
HydrALAZINE HCl 100 mg tablet$ 1.05
Hydralazine-HCTZ 25-25 mg capsule$ 0.81
Hydralazine-HCTZ 100-50 mg capsule$ 0.75
HydrALAZINE HCl 50 mg tablet$ 0.67
Apresoline 50 mg tablet$ 0.65
HydrALAZINE HCl 25 mg tablet$ 0.53
HydrALAZINE HCl 10 mg tablet$ 0.47
Hydralazine 50 mg tablet$ 0.44
Hydralazine 25 mg tablet$ 0.35
Apo-Hydralazine 50 mg Tablet$ 0.29
Novo-Hylazin 50 mg Tablet$ 0.29
Apo-Hydralazine 25 mg Tablet$ 0.24
Hydralazine 10 mg tablet$ 0.22
Apo-Hydralazine 10 mg Tablet$ 0.11
Novo-Hylazin 10 mg Tablet$ 0.11
Hydralazine tablet 10 mg (Aa Pharma Inc (Canada))
Hydralazine tablet 25 mg (Aa Pharma Inc (Canada))
Hydralazine tablet 50 mg (Aa Pharma Inc (Canada))
Hydralazine tablet 25 mg/1 (Cardinal Health (US))
Hydralazine tablet 50 mg/1 (Cardinal Health (US))
Hylazine 25 mg (Unijules Life Sciences)
Hylazine 25 mg x Blister pk (Unijules Life Sciences)

References

  1. PubChem. "hydralazine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "hydralazine". http://www.drugbank.ca/drugs/DB01275 (accessed September 17, 2018).
  3. DTP/NCI. "hydralazine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Hipoftalin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hipoftalin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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