Hyclo S Actions
Hyclo S extended-release tablets have analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of Hyclo S extended-release tablets, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Hyclo S is a potent inhibitor of prostaglandin synthesis in vitro. Hyclo S concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because Hyclo S is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Keep using Hyclo S for the full time of treatment. However, do not use Hyclo S more often or for a longer time than your doctor ordered. Hyclo S is not for long-term use.
Hyclo S should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.
When used for severe or continuing arthritis, Hyclo S must be taken every day as ordered by your doctor in order for it to help you. Hyclo S usually begins to work within one week, but in severe cases up to two weeks or longer may pass before you begin to feel better. Several weeks may pass before you feel the full effects of Hyclo S.
You may take Hyclo S with or without food. However, Hyclo S capsules should be taken on an empty stomach.
To use the oral solution:
Use only the brand of Hyclo S that your doctor prescribed. Different brands may not work the same way.
The dose of Hyclo S will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Hyclo S. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of Hyclo S, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
If you switch brands of Hyclo S, your dose needs may change. Follow your doctor's instructions about how much medicine to take.
Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.
Dissolve the Hyclo S powder (Hyclo S) with 1 to 2 ounces of water. Do not use any other type of liquid. Stir this mixture and drink all of it right away. Hyclo S powder works best if you take it on an empty stomach.
Call your doctor if your headache does not completely go away after taking Hyclo S. Do not take a second dose of Hyclo S powder without your doctor's advice.
Do not crush, chew, or break an enteric-coated pill. Swallow the pill whole. The enteric-coated pill has a special coating to protect your stomach. Breaking the pill could damage this coating.
If you use this medication long-term, your liver function will need to be checked with frequent blood tests. Visit your doctor regularly.
Store at room temperature away from moisture and heat.
Hyclo S is one of a series of phenylacetic acids that has demonstrated anti-inflammatory and analgesic properties in pharmacological studies. It is thought to inhibit the enzyme cyclooxygenase, which is essential in the biosynthesis of prostaglandins.
Prostaglandins have been shown in many animal models to be mediators of certain kinds of intraocular inflammation. In studies performed in animal eyes, prostaglandins have been shown to produce disruption of the blood-aqueous humor barrier, vasodilation, increased vascular permeability, leukocytosis, and increased intraocular pressure.
Results from a bioavailability study established that plasma levels of Hyclo S following ocular instillation of two drops of Hyclo S ophthalmic solution, 0.1% to each eye were below the limit of quantification (10 ng/mL) over a 4-hour period. This study suggests that limited, if any, systemic absorption occurs with Hyclo S ophthalmic solution, 0.1%.
Postoperative Anti-Inflammatory Effects
In two double-masked, controlled, efficacy studies of postoperative inflammation, a total of 206 cataract patients were treated with Hyclo S ophthalmic solution, 0.1% and 103 patients were treated with vehicle placebo. Hyclo S ophthalmic solution, 0.1% was favored over vehicle placebo over a 2-week period for the clinical assessments of inflammation as measured by anterior chamber cells and flare.
In double-masked, controlled studies of corneal refractive surgery (radial keratotomy (RK) and laser photorefractive keratectomy (PRK)) patients were treated with Hyclo S ophthalmic solution, 0.1% and/or vehicle placebo. The efficacy of Hyclo S ophthalmic solution, 0.1% given before and shortly after surgery was favored over vehicle placebo during the 6-hour period following surgery for the clinical assessments of pain and photophobia. Patients were permitted to use a hydrogel soft contact lens with Hyclo S ophthalmic solution, 0.1% for up to three days after PRK.
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Information checked by Dr. Sachin Kumar, MD Pharmacology