Hydralazine Hydrochloride Uses

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What is Hydralazine Hydrochloride?

Treating high blood pressure. It may be used alone or in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Hydralazine Hydrochloride tablets is a vasodilator. It works by relaxing and dilating (opening) the blood vessels in the body, allowing blood to flow through the vessels more easily and at a lower pressure.

Hydralazine Hydrochloride indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Essential hypertension, alone or as an adjunct.

How should I use Hydralazine Hydrochloride?

Use Hydralazine Hydrochloride tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Hydralazine Hydrochloride tablets.

Uses of Hydralazine Hydrochloride in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use: Labeled Indications

Hypertension: Management of moderate to severe hypertension. Note: Not recommended for the initial treatment of hypertension (ACC/AHA [Whelton 2017])

Off Label Uses

Heart failure with reduced ejection fraction

Data from a randomized, double-blind trial comparing enalapril and Hydralazine Hydrochloride plus isosorbide dinitrate in patients with chronic heart failure with reduced ejection fraction (HFrEF) support the use of Hydralazine Hydrochloride (in combination with isosorbide dinitrate) in patients with intolerance to angiotensin-converting enzyme (ACE) inhibitor therapy.

Hydralazine Hydrochloride description

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A direct-acting vasodilator that is used as an antihypertensive agent. [PubChem]

Hydralazine Hydrochloride dosage

Initiate therapy in gradually increasing dosages; adjust according to individual response. Start with 10 mg four times daily for the first 2 to 4 days, increase to 25 mg four times daily for the balance of the first week. For the second and subsequent weeks, increase dosage to 50 mg four times daily. For maintenance, adjust dosage to the lowest effective levels.

The incidence of toxic reactions, particularly the L.E. cell syndrome, is high in the group of patients receiving large doses of Hydralazine Hydrochloride tablets.

In a few resistant patients, up to 300 mg of Hydralazine Hydrochloride tablets daily may be required for a significant antihypertensive effect. In such cases, a lower dosage of Hydralazine Hydrochloride tablets combined with a thiazide and/or reserpine or a beta blocker may be considered. However, when combining therapy, individual titration is essential to ensure the lowest possible therapeutic dose of each drug.

Hydralazine Hydrochloride interactions

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What other drugs will affect Hydralazine Hydrochloride?

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Alfuzosin: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Amifostine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Amifostine. Management: When amifostine is used at chemotherapy doses, blood pressure lowering medications should be withheld for 24 hours prior to amifostine administration. If blood pressure lowering therapy cannot be withheld, amifostine should not be administered. Consider therapy modification

Amphetamines: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Antipsychotic Agents (Second Generation [Atypical]): Blood Pressure Lowering Agents may enhance the hypotensive effect of Antipsychotic Agents (Second Generation [Atypical]). Monitor therapy

Barbiturates: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Benperidol: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Brigatinib: May diminish the antihypertensive effect of Antihypertensive Agents. Brigatinib may enhance the bradycardic effect of Antihypertensive Agents. Monitor therapy

Brimonidine (Topical): May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Bromperidol: May diminish the hypotensive effect of Blood Pressure Lowering Agents. Blood Pressure Lowering Agents may enhance the hypotensive effect of Bromperidol. Avoid combination

Dapoxetine: May enhance the orthostatic hypotensive effect of Hydralazine Hydrochloride. Monitor therapy

Dexmethylphenidate: May diminish the therapeutic effect of Antihypertensive Agents. Monitor therapy

Diazoxide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

DULoxetine: Blood Pressure Lowering Agents may enhance the hypotensive effect of DULoxetine. Monitor therapy

Herbs (Hypertensive Properties): May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Herbs (Hypotensive Properties): May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Hypotension-Associated Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect of Hypotension-Associated Agents. Monitor therapy

Levodopa-Containing Products: Blood Pressure Lowering Agents may enhance the hypotensive effect of Levodopa-Containing Products. Monitor therapy

Lormetazepam: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Methylphenidate: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Molsidomine: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Naftopidil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Nicergoline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Nicorandil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Nitroprusside: Blood Pressure Lowering Agents may enhance the hypotensive effect of Nitroprusside. Monitor therapy

Nonsteroidal Anti-Inflammatory Agents: May diminish the antihypertensive effect of Hydralazine Hydrochloride. Monitor therapy

Obinutuzumab: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Management: Consider temporarily withholding blood pressure lowering medications beginning 12 hours prior to obinutuzumab infusion and continuing until 1 hour after the end of the infusion. Consider therapy modification

Pentoxifylline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Pholcodine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Pholcodine. Monitor therapy

Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Prostacyclin Analogues: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Quinagolide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Yohimbine: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Hydralazine Hydrochloride side effects

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What are the possible side effects of Hydralazine Hydrochloride?

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Adverse reactions with Hydralazine Hydrochloride are usually reversible when dosage is reduced. However, in some cases it may be necessary to discontinue the drug. The following adverse reactions have been observed, but there has not been enough systematic collection of data to support an estimate of their frequency.

Common

headache, anorexia, nausea, vomiting, diarrhea, palpitations, tachycardia, angina pectoris

Less Frequent

Digestive

constipation, paralytic ileus.

Cardiovascular

hypotension, paradoxical pressor response, edema.

Respiratory

dyspnea.

Neurologic

peripheral neuritis, evidenced by paresthesia, numbness, and tingling; dizziness; tremors; muscle cramps; psychotic reactions characterized by depression, disorientation, or anxiety.

Genitourinary

difficulty in urination

Hematologic

blood dyscrasias, consisting of reduction in hemoglobin and red cell count, leukopenia, agranulocytosis, purpura; lymphadenopathy; splenomegaly.

Hypersensitive Reactions

rash, urticaria, pruritus, fever, chills, arthralgia, eosinophilia, and rarely, hepatitis.

Other

nasal congestion, flushing, lacrimation, conjunctivitis.

Hydralazine Hydrochloride contraindications

See also:
What is the most important information I should know about Hydralazine Hydrochloride?

Hypersensitivity to Hydralazine Hydrochloride; coronary artery disease; mitral valvular rheumatic heart disease.

Active ingredient matches for Hydralazine Hydrochloride:

Hydralazine Hydrochloride


Unit description / dosage (Manufacturer)Price, USD
100 tablet in 1 bottle
1000 tablet in 1 bottle
500 tablet in 1 bottle
HYDRALAZINE HYDROCHLORIDE 20MG INJECTION 1 vial / 1 injection each (Bharat Serums & Vaccines Ltd)$ 6.35
Hydralazine Hydrochloride tablet, film coated 25 mg/1 (Unit Dose Services (US))
Hydralazine Hydrochloride tablet 25 mg/1 (REMEDYREPACK INC. (US))
Hydralazine Hydrochloride injection, solution 20 mg/mL (Physicians Total Care, Inc. (US))
Hydralazine Hydrochloride injection 20 mg/mL (Cardinal Health (US))
Hydralazine Hydrochloride tablet 100 mg/1 (Camber Pharmaceuticals (US))
Hydralazine Hydrochloride tablet 50 mg/1 (Glenmark Pharmaceuticals Inc., Usa (US))
Hydralazine Hydrochloride tablet 10 mg/1 (Par Pharmaceutical, Inc. (US))
Hydralazine Hydrochloride tablet, film coated 50 mg/1 (Major Pharmaceuticals (US))
Hydralazine Hydrochloride tablet, film coated 10 mg/1 (REMEDYREPACK INC. (US))
Hydralazine Hydrochloride tablet, film coated 100 mg/1 (Aphena Pharma Solutions Tennessee, Llc (US))
Hydralazine Hydrochloride 20mg Injection (Bharat Serums & Vaccines Ltd)$ 6.35

List of Hydralazine Hydrochloride substitutes (brand and generic names):

Hylazine 25 mg (Unijules Life Sciences)
Hylazine 25 mg x Blister pk (Unijules Life Sciences)
Lisheu 25 mg
Lisheu 50 mg
Tablet; Oral; Hydralazine Hydrochloride 10 mg (Novopharm)
Tablet; Oral; Hydralazine Hydrochloride 25 mg (Novopharm)
Tablet; Oral; Hydralazine Hydrochloride 50 mg (Novopharm)
Tablet; Oral; Hydralazine Hydrochloride 10 mg (Nu-pharm)
Tablet; Oral; Hydralazine Hydrochloride 25 mg (Nu-pharm)
Tablet; Oral; Hydralazine Hydrochloride 50 mg (Nu-pharm)
Phil Pharmawealth/Oboi Hydralazine / amp 20 mg/1 mL x 1 mL x 10's (Oboi)
Phil Pharmawealth/Oboi Hydralazine 20 mg/1 mL x 1 mL x 100's (Oboi)
Phil Pharmawealth/Oboi Hydralazine inj 20 mg/mL / amp 1 mL x 10 x 1's (Oboi)
Phil Pharmawealth/Oboi Hydralazine inj 20 mg/mL 1 mL x 100 x 1's (Oboi)
Serpathiazide 25 mg (Washington)
Serpine 10 mg
Stable 10 mg x 100's (Domag Smith Labs Pvt Ltd)
Stable 10 mg x 1000's (Domag Smith Labs Pvt Ltd)
Stable 10 mg x 10 x 10's (Domag Smith Labs Pvt Ltd)
Stable 25 mg x 100's (Domag Smith Labs Pvt Ltd)
Stable 25 mg x 1000's (Domag Smith Labs Pvt Ltd)
Stable 25 mg x Blister pk (Domag Smith Labs Pvt Ltd)
Stable 500 mg Injection (Domag Smith Labs Pvt Ltd)$ 0.73
Stable 250 mg Injection (Domag Smith Labs Pvt Ltd)$ 0.94
Susemide 25 mg

References

  1. PubChem. "hydralazine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "hydralazine". http://www.drugbank.ca/drugs/DB01275 (accessed September 17, 2018).
  3. DTP/NCI. "hydralazine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).

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