What is Hydrocortisone Carolina?
Hydrocortisone Carolina is in a class of drugs called steroids. Hydrocortisone Carolina prevents the release of substances in the body that cause inflammation.
Salicylic acid and sulfur topical (for the skin) work together to soften scales and psoriasis plaques and cause shedding of the outer layer of skin.
The combination of Hydrocortisone Carolina, salicylic acid, and sulfur is used to treat inflammation, itching, flaking, scaling, and other symptoms of scalp psoriasis or seborrheic dermatitis.
This medication is supplied as a kit containing Hydrocortisone Carolina lotion, salicylic acid and sulfur shampoo, and a cleansing shampoo.
Hydrocortisone Carolina, salicylic acid, and sulfur may also be used for purposes not listed in this medication guide.
Hydrocortisone Carolina indications
1. Endocrine Disorders
Primary or secondary adrenocortical insufficiency (hydrocortisone or Hydrocortisone Carolina is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance).
Congenital adrenal hyperplasia Nonsuppurative thyroiditis Hypercalcemia associated with cancer
2. Rheumatic Disorders
As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:
Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy) Ankylosing spondylitis
Acute and subacute bursitis Acute nonspecific tenosynovitis Acute gouty arthritis
Post-traumatic osteoarthritis Synovitis of osteoarthritis Epicondylitis
3. Collagen Diseases
During an exacerbation or as maintenance therapy in selected cases of:
Systemic lupus erythematosus
Acute rheumatic carditis
Systemic dermatomyositis (polymyositis)
4. Dermatologic Diseases
Bullous dermatitis herpetiformis
Severe erythema multiforme (Stevens-Johnson syndrome) Exfoliative dermatitis
Severe seborrheic dermatitis
5. Allergic States
Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:
Seasonal or perennial allergic rhinitis
Bronchial asthma Contact dermatitis Atopic dermatitis Serum sickness
Drug hypersensitivity reactions
6. Ophthalmic Diseases
Severe acute and chronic allergic and inflammatory processes
involving the eye and its adnexa, such as: Allergic conjunctivitis
Allergic corneal marginal ulcers Herpes zoster ophthalmicus Iritis and iridocyclitis Chorioretinitis
Anterior segment inflammation
Diffuse posterior uveitis and choroiditis
7. Respiratory Diseases
Loeffler’s syndrome not manageable by other means
Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculosis chemotherapy Aspiration
8. Hematologic Disorders
Idiopathic thrombocytopenic purpura in adults Secondary thrombocytopenia in adults Acquired (autoimmune) hemolytic anemia
Erythroblastopenia (RBC anemia)
Congenital (erythroid) hypoplastic anemia
9. Neoplastic Diseases
For palliative management of: Leukemias and lymphomas in adults Acute leukemia of childhood
10. Edematous States
To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus
11. Gastrointestinal Diseases
To tide the patient over a critical period of the disease in: Ulcerative colitis
Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy
Trichinosis with neurologic or myocardial involvement
How should I use Hydrocortisone Carolina?
Use Hydrocortisone Carolina as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Hydrocortisone Carolina is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Hydrocortisone Carolina at home, a health care provider will teach you how to use it. Be sure you understand how to use Hydrocortisone Carolina. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Hydrocortisone Carolina if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Hydrocortisone Carolina, contact your doctor right away.
Ask your health care provider any questions you may have about how to use Hydrocortisone Carolina.
Uses of Hydrocortisone Carolina in details
It is used as a cream to treat mild to moderate inflammatory skin disorders such as mild to moderate eczema (itchy skin rash)contact dermatitis (e.g. after contact with certain plants, cosmetics, irritants like detergents), insect bite reactions.
Orally it is used to reduce pain, swelling and inflammation and to reduce the body's immune response. In general this drug is used to treat hormonal conditions when the body does not produce enough of its own steroids, and to treat a range of immune and allergic conditions. Hydrocortisone Carolina is used as an injection for treating various conditions such as severe allergic reactions, arthritis, blood diseases, breathing problems, certain cancers, eye diseases, intestinal disorders, and skin diseases. The injectable form of Hydrocortisone Carolina is used when a similar drug cannot be taken by mouth or when a very fast treatment is needed, especially in patients with severe medical conditions. This drug may also be used with other medications as a replacement for certain hormones.
Hydrocortisone Carolina description
Hydrocortisone Carolina contains dissolved Hydrocortisone Carolina 0.5% for improved effectiveness in a special occlusive cream base. It is paraben-, lanolin- and chlorocresol-free with a pH 5.
Hydrocortisone Carolina dosage
The use of Hydrocortisone Carolina Rectal Suspension, USP Hydrocortisone Carolina retention enema is predicated upon the concomitant use of modern supportive measures such as rational dietary control, sedatives, antidiarrheal agents, antibacterial therapy, blood replacement if necessary, etc.
The usual course of therapy is one Hydrocortisone Carolina Rectal Suspension, USP nightly for 21 days, or until the patient comes into remission both clinically and proctologically. Clinical symptoms usually subside promptly within 3 to 5 days. Improvement in the appearance of the mucosa, as seen by sigmoidoscopic examination, may lag somewhat behind clinical improvement. Difficult cases may require as long as 2 or 3 months of Hydrocortisone Carolina Rectal Suspension, USP treatment. Where the course of therapy extends beyond 21 days, Hydrocortisone Carolina Rectal Suspension, USP should be discontinued gradually by reducing administration to every other night for 2 or 3 weeks.
If clinical or proctologic improvement fails to occur within 2 or 3 weeks after starting Hydrocortisone Carolina Rectal Suspension, USP, discontinue its use.
Symptomatic improvement, evidenced by decreased diarrhea and bleeding; weight gain; improved appetite; lessened fever; and decrease in leukocytosis, may be misleading and should not be used as the sole criterion in judging efficacy. Sigmoidoscopic examination and X-ray visualization are essential for adequate monitoring of ulcerative colitis. Biopsy is useful for differential diagnosis.
Patient instructions for administering Hydrocortisone Carolina Rectal Suspension, USP are enclosed in each box. It is recommended that the patient lie on their left side during administration and for 30 minutes thereafter, so that the fluid will distribute throughout the left colon. Every effort should be made to retain the enema for at least an hour and preferably, all night. This may be facilitated by prior sedation and/or antidiarrheal medication, especially early in therapy when the urge to evacuate is great.
Hydrocortisone Carolina interactions
With simultaneous use of Hydrocortisone Carolina increases the toxicity of cardiac glycosides (because of the emerging hypokalemia increases the risk of arrhythmias); with acetylsalicylic acid - accelerates its excretion and reduces its concentration in blood plasma (with the abolition of Hydrocortisone Carolina concentration of salicylates in the blood increases, and increases the risk of side effects); with paracetamol - increased risk of hepatotoxic action of paracetamol (induction of hepatic enzymes and formation of a toxic metabolite of paracetamol); with cyclosporine - increased side effects of Hydrocortisone Carolina as a result of inhibition of its metabolism; with ketoconazole - increased side effects of Hydrocortisone Carolina as a result of reduction of its clearance.
Hydrocortisone Carolina ICM Pharma reduces the effectiveness of hypoglycemic; intensifies the effect of indirect anticoagulants of coumarin derivatives.
Hydrocortisone Carolina reduces the effect of vitamin D on the absorption of calcium ions into the lumen of the intestine. Ergocalciferol and parathyroid hormone hinder the development of osteopathy caused by GCS.
Hydrocortisone Carolina ICM Pharma increases the metabolism of isoniazid, meksiletina (especially in "fast acetylators"), which leads to a decrease in their plasma concentrations; increases (with prolonged therapy) the content of folic acid reduces the concentration of praziquantel in blood.
Hydrocortisone Carolina in high doses reduces the effect somatropina.
Hypokalemia caused by GCS, may increase the severity and duration of muscle blockade on the background of muscle relaxants.
Antacids reduce the absorption of the GCS.
At simultaneous application with SCS thiazides, carbonic anhydrase inhibitors, other GCS, amphotericin B increase the risk of hypokalemia, drugs containing sodium ions - swelling and increase blood pressure.
NSAIDs and ethanol increases the risk of gastrointestinal ulcerations and bleeding, in combination with NSAIDs to treat arthritis may reduce the dose of GCS due to summation of therapeutic effect. Indomethacin displacing the SCS from its association with albumin, increases the risk of its side effects.
Amphotericin B and carbonic anhydrase inhibitors increase the risk of osteoporosis.
The therapeutic effect of GCS is reduced under the influence of inducers of microsomal liver enzymes (including phenytoin, barbiturates, ephedrine, theophylline, rifampin) due to increased rate of metabolism of these substances.
Inhibitors of the function of the adrenal cortex (including mitotan) may necessitate higher doses of GCS.
Clearance GCS increased against the background of preparations of thyroid hormones.
Immunosuppressants increase the risk of infection and lymphoma or other lymphoproliferative disorders associated with Epstein-Barr virus.
Estrogens (including oral contraceptives containing estrogen) reduce the clearance of GKS, lengthens T1/2 and their therapeutic and toxic effects. The appearance of hirsutism and acne promotes the simultaneous use of other steroid hormone funds - androgens, estrogens, anabolic steroids, oral contraceptives.
Tricyclic antidepressants may increase the severity of depression caused by GCS (not shown for the treatment of these side effects).
The risk of developing cataracts increases with the application against other GCS antipsychotic funds (neuroleptics), carbutamide and azathioprine. Simultaneous of Hydrocortisone Carolina ICM Pharma with the appointment of m-cholinoblockers, as well as with means having m-anticholinergic action (including antihistamines, tricyclic antidepressants), with nitrates improves the intraocular pressure.
With simultaneous application of SCS with live vaccines and antiviral compared to other types of immunization increases the risk of activation of viruses and development of infections.
Hydrocortisone Carolina side effects
Applies to Hydrocortisone Carolina: oral suspension, oral tablet
In addition to its needed effects, some unwanted effects may be caused by Hydrocortisone Carolina. In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Hydrocortisone Carolina:
- blurred vision
- decrease in the amount of urine
- fast, slow, pounding, or irregular heartbeat or pulse
- mental depression
- mood changes
- noisy, rattling breathing
- numbness or tingling in the arms or legs
- pounding in the ears
- shortness of breath
- swelling of the fingers, hands, feet, or lower legs
- trouble thinking, speaking, or walking
- troubled breathing at rest
- weight gain
- Abdominal cramping and/or burning (severe)
- abdominal pain
- bloody, black, or tarry stools
- cough or hoarseness
- darkening of skin
- decrease in height
- decreased vision
- dry mouth
- eye pain
- eye tearing
- facial hair growth in females
- fever or chills
- flushed, dry skin
- fruit-like breath odor
- full or round face, neck, or trunk
- heartburn and/or indigestion (severe and continuous)
- increased hunger
- increased thirst
- increased urination
- loss of appetite
- loss of sexual desire or ability
- lower back or side pain
- menstrual irregularities
- muscle pain or tenderness
- muscle wasting or weakness
- pain in back, ribs, arms, or legs
- painful or difficult urination
- skin rash
- trouble healing
- trouble sleeping
- unexplained weight loss
- unusual tiredness or weakness
- vision changes
- vomiting of material that looks like coffee grounds
Minor Side Effects
Some of the side effects that can occur with Hydrocortisone Carolina may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
- Increased appetite
- Abnormal fat deposits on the face, neck, and trunk
- dry scalp
- lightening of normal skin color
- red face
- reddish purple lines on the arms, face, legs, trunk, or groin
- swelling of the stomach area
- thinning of the scalp hair
Hydrocortisone Carolina contraindications
For short-term use of Hydrocortisone Carolina Sunward Pharmaceutical according to the life - hypersensitivity to Hydrocortisone Carolina. For intraarticular administration and injection directly into the lesion: previous arthroplasty, abnormal bleeding (endogenous or caused by the use of anticoagulants), intra-articular fracture, infection (septic) inflammatory process in joints and periarticular infections (including history), and also general infectious disease marked juxta-articular osteoporosis, lack of signs of inflammation in the joint ("dry" joint, such as osteoarthrosis without synovitis), marked bone destruction and deformity of joints (sharp narrowing of joint space, ankylosis), instability of the joint as a result of arthritis, aseptic necrosis of the epiphyses of bones forming the joint.
For external use: bacterial, viral, fungal skin diseases, tuberculosis, skin, cutaneous manifestations of syphilis, tumors of the skin, post-vaccination period, violation of the integrity of the skin (ulcers, wounds), children's age (up to 2 years, with itching in the anal area - up to 12 years), rosacea, acne vulgaris, perioral dermatitis.
For use in ophthalmology: bacterial, viral, fungal eye diseases, tuberculosis eye disease, trachoma, violation of the integrity of the eye epithelium.
Active ingredient matches for Hydrocortisone Carolina:
Hydrocortisone in United States.
List of Hydrocortisone Carolina substitutes (brand and generic names)
|Sort by popularity|
|Unit description / dosage (Manufacturer)||Price, USD|
|Cream; Topical; Hydrocortisone 0.5%|
|Hydrocortisoni PCH (Netherlands)|
|Hydrocortisonum (Lithuania, Poland)|
|Hydrocortisonum 10 Bottle|
|Hydrocortisonum 1% Aflofarm (Poland)|
|Hydrocortisonum Aflofarm (Poland)|
|Hydrocortisonum AFP (Poland)|
|Hydrocortisonum Homeofarm (Poland)|
|Hydrocortisonum Jelfa (Latvia, Poland)|
|Hydrocortisonum Oceanic (Poland)|
|Hydrocortisonum Polfa (Lithuania)|
|Hydrocortistab (United Kingdom)|
|Injectable; Injection; Hydrocortisone Acetate 2.5% (Sovereign)|
|Hydrocortisyl (Ethiopia, Ireland, Malta)|
|Hydrocortone (Austria, Ireland, Japan, Portugal, Switzerland, United States)|
|Injectable; Injection; Hydrocortisone Sodium Phosphate 25 mg / ml (Auden mckenzie)|
|Injectable; Injection; Hydrocortisone Sodium Phosphate 50 mg / ml (Auden mckenzie)|
|Ointment; Ophthalmic, Otic; Hydrocortisone Sodium Phosphate 1.5% (Auden mckenzie)|
|Tablet; Oral; Hydrocortisone Sodium Phosphate 10 mg (Auden mckenzie)|
|Tablet; Oral; Hydrocortisone Sodium Phosphate 20 mg (Auden mckenzie)|
|Tablets; Oral; Hydrocortisone Sodium Phosphate 10 mg (Auden mckenzie)|
|Tablets; Oral; Hydrocortisone Sodium Phosphate 20 mg (Auden mckenzie)|
|Ointment; Topical; Hydrocortisone Acetate 1% (Dermapharm)|
|Hydrocutan 0.25% (Germany)|
|Hydrocutan 1% (Germany)|
|Hydrocutan Creme (Germany)|
|Hydrocutan Mild (Germany)|
|Ointment; Topical; Hydrocortisone 1% (Dermapharm)|
|Hydrocutan Salbe (Germany)|
|Hydrocutan Tabletten (Germany)|
|Hydroderm Aesca (Austria)|
|Hydroderm HC (Germany)|
|Cream; Topical; Hydrocortisone 0.5% (Karrer)|
|Cream; Topical; Hydrocortisone (Galen)|
|Lotion; Topical; Hydrocortisone (Galen)|
|Ointment; Topical; Hydrocortisone (Galen)|
|Solution; Topical; Hydrocortisone (Galen)|
|Hydrokortison CCS (Norway, Sweden)|
|Hydrokortison Clean Chemical Sweden (Sweden)|
|Hydrokortison DnE (Denmark)|
|Hydrokortison Galderma (Denmark, Norway)|
|Hydrokortison Nycomed (Denmark, Sweden)|
- DailyMed. "CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "hydrocortisone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "hydrocortisone". http://www.drugbank.ca/drugs/DB00741 (accessed September 17, 2018).
- DTP/NCI. "hydrocortisone: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
- Wikipedia. "cortisol: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Cortis... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology