Hydrocortisyl Uses

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What is Hydrocortisyl?

Hydrocortisyl provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, ulcerative colitis, and flare-ups of multiple sclerosis. Hydrocortisyl is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions.

Hydrocortisyl is available only with your doctor's prescription.

Hydrocortisyl indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Hydrocortisyl Tablets, USP are indicated in the following conditions:

1. Endocrine Disorders

Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be

used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular

importance)

Congenital adrenal hyperplasia

Nonsuppurative thyroiditis

Hypercalcemia associated with cancer

2. Rheumatic Disorders

As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:

Psoriatic arthritis

Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)

Ankylosing spondylitis

Acute and subacute bursitis

Acute nonspecific tenosynovitis

Acute gouty arthritis

Post-traumatic osteoarthritis

Synovitis or osteoarthritis

Epicondylitis

3. Collagen Diseases

During an exacerbation or as maintenance therapy in selected cases of:

Systemic lupus erythematosus

Acute rheumatic carditis

Systemic dermatomyositis (polymyositis)

4. Dermatologic Diseases

Pemphigus

Bullous dermatitis herpetiformis

Severe erythema multiforme (Stevens-Johnson syndrome)

Exfoliative dermatitis

Mycosis fungoides

Severe psoriasis

Severe seborrheic dermatitis

5. Allergic States

Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:

Seasonal or perennial allergic rhinitis

Bronchial asthma

Contact dermatitis

Atopic dermatitis

Serum sickness

Drug hypersensitivity reactions

6. Ophthalmic Diseases

Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa, such as:

Allergic conjunctivitis

Keratitis

Allergic corneal marginal ulcers

Herpes zoster ophthalmicus

Iritis and iridocyclitis

Chorioretinitis

Anterior segment inflammation

Diffuse posterior uveitis and choroiditis

Optic neuritis

Sympathetic ophthalmia

7. Respiratory Disease

Symptomatic sarcoidosis

Loeffler’s syndrome not manageable by other means

Berylliosis

Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculosis chemotherapy

Aspiration pneumonitis

8. Hematologic Disorder

Idiopathic thrombocytopenic purpura in adults

Secondary thrombocytopenia in adults

Acquired (autoimmune) hemolytic anemia

Erythroblastopenia (RBC anemia)

Congenital (erythroid) hypoplastic anemia

9. Neoplastic Diseases

For palliative management of:

Leukemias and lymphomas in adults

Acute leukemia of childhood

10. Edematous States

To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that

due to lupus erythematosus.

11. Gastrointestinal Diseases

To tide the patient over a critical period of the disease in:

Ulcerative colitis

Regional enteritis

12. Miscellaneous

Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate

antituberculous chemotherapy

Trichinosis with neurologic or myocardial involvement

How should I use Hydrocortisyl?

Use Hydrocortisyl solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Hydrocortisyl solution is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Hydrocortisyl solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Hydrocortisyl solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Hydrocortisyl solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Hydrocortisyl solution, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Hydrocortisyl solution.

Uses of Hydrocortisyl in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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It is used as a cream to treat mild to moderate inflammatory skin disorders such as mild to moderate eczema (itchy skin rash)contact dermatitis (e.g. after contact with certain plants, cosmetics, irritants like detergents), insect bite reactions.

Orally it is used to reduce pain, swelling and inflammation and to reduce the body's immune response. In general this drug is used to treat hormonal conditions when the body does not produce enough of its own steroids, and to treat a range of immune and allergic conditions. Hydrocortisyl is used as an injection for treating various conditions such as severe allergic reactions, arthritis, blood diseases, breathing problems, certain cancers, eye diseases, intestinal disorders, and skin diseases. The injectable form of Hydrocortisyl is used when a similar drug cannot be taken by mouth or when a very fast treatment is needed, especially in patients with severe medical conditions. This drug may also be used with other medications as a replacement for certain hormones.

Hydrocortisyl description

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Hydrocortisyl 100 mg contains Hydrocortisone sodium succinate equivalent to Hydrocortisyl 100 mg, monobasic sodium phosphate 1 mg, dibasic sodium 9 mg and sodium hydroxide 10%.

Hydrocortisyl 100 mg/2 mL contains Hydrocortisone sodium succinate equivalent to Hydrocortisyl 100 mg/2 mL, monobasic sodium phosphate 1 mg, dibasic sodium 10 mg and sodium hydroxide 10%.

Hydrocortisyl 250 mg/2 mL contains Hydrocortisone sodium succinate equivalent to Hydrocortisyl 250 mg/2 mL, monobasic sodium phosphate 2 mg, dibasic sodium phosphate 25 mg and sodium hydroxide 10%.

Hydrocortisyl 500 mg/4 mL contains Hydrocortisone sodium succinate equivalent to Hydrocortisyl 500 mg/4 mL, monobasic sodium phosphate 5 mg, dibasic sodium phosphate 52 mg and sodium hydroxide 10%.

Hydrocortisyl sodium succinate or pregn-4-ene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy; monosodium salt,(11β) is an anti-inflammatory adrenocortical steroid. This highly water-soluble sodium succinate ester of Hydrocortisyl permits the immediate IV administration of high doses of Hydrocortisyl in a small volume of diluent and is particularly useful where high blood levels of Hydrocortisyl are required rapidly.

When necessary, the pH of Hydrocortisyl was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7-8.

Hydrocortisyl dosage

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The use of Hydrocortisyl Rectal Suspension, USP Hydrocortisyl retention enema is predicated upon the concomitant use of modern supportive measures such as rational dietary control, sedatives, antidiarrheal agents, antibacterial therapy, blood replacement if necessary, etc.

The usual course of therapy is one Hydrocortisyl Rectal Suspension, USP nightly for 21 days, or until the patient comes into remission both clinically and proctologically. Clinical symptoms usually subside promptly within 3 to 5 days. Improvement in the appearance of the mucosa, as seen by sigmoidoscopic examination, may lag somewhat behind clinical improvement. Difficult cases may require as long as 2 or 3 months of Hydrocortisyl Rectal Suspension, USP treatment. Where the course of therapy extends beyond 21 days, Hydrocortisyl Rectal Suspension, USP should be discontinued gradually by reducing administration to every other night for 2 or 3 weeks.

If clinical or proctologic improvement fails to occur within 2 or 3 weeks after starting Hydrocortisyl Rectal Suspension, USP, discontinue its use.

Symptomatic improvement, evidenced by decreased diarrhea and bleeding; weight gain; improved appetite; lessened fever; and decrease in leukocytosis, may be misleading and should not be used as the sole criterion in judging efficacy. Sigmoidoscopic examination and X-ray visualization are essential for adequate monitoring of ulcerative colitis. Biopsy is useful for differential diagnosis.

Patient instructions for administering Hydrocortisyl Rectal Suspension, USP are enclosed in each box. It is recommended that the patient lie on their left side during administration and for 30 minutes thereafter, so that the fluid will distribute throughout the left colon. Every effort should be made to retain the enema for at least an hour and preferably, all night. This may be facilitated by prior sedation and/or antidiarrheal medication, especially early in therapy when the urge to evacuate is great.

Hydrocortisyl interactions

With simultaneous use of Hydrocortisyl increases the toxicity of cardiac glycosides (because of the emerging hypokalemia increases the risk of arrhythmias); with acetylsalicylic acid - accelerates its excretion and reduces its concentration in blood plasma (with the abolition of Hydrocortisyl concentration of salicylates in the blood increases, and increases the risk of side effects); with paracetamol - increased risk of hepatotoxic action of paracetamol (induction of hepatic enzymes and formation of a toxic metabolite of paracetamol); with cyclosporine - increased side effects of Hydrocortisyl as a result of inhibition of its metabolism; with ketoconazole - increased side effects of Hydrocortisyl as a result of reduction of its clearance.

Hydrocortisyl ICM Pharma reduces the effectiveness of hypoglycemic; intensifies the effect of indirect anticoagulants of coumarin derivatives.

Hydrocortisyl reduces the effect of vitamin D on the absorption of calcium ions into the lumen of the intestine. Ergocalciferol and parathyroid hormone hinder the development of osteopathy caused by GCS.

Hydrocortisyl ICM Pharma increases the metabolism of isoniazid, meksiletina (especially in "fast acetylators"), which leads to a decrease in their plasma concentrations; increases (with prolonged therapy) the content of folic acid reduces the concentration of praziquantel in blood.

Hydrocortisyl in high doses reduces the effect somatropina.

Hypokalemia caused by GCS, may increase the severity and duration of muscle blockade on the background of muscle relaxants.

Antacids reduce the absorption of the GCS.

At simultaneous application with SCS thiazides, carbonic anhydrase inhibitors, other GCS, amphotericin B increase the risk of hypokalemia, drugs containing sodium ions - swelling and increase blood pressure.

NSAIDs and ethanol increases the risk of gastrointestinal ulcerations and bleeding, in combination with NSAIDs to treat arthritis may reduce the dose of GCS due to summation of therapeutic effect. Indomethacin displacing the SCS from its association with albumin, increases the risk of its side effects.

Amphotericin B and carbonic anhydrase inhibitors increase the risk of osteoporosis.

The therapeutic effect of GCS is reduced under the influence of inducers of microsomal liver enzymes (including phenytoin, barbiturates, ephedrine, theophylline, rifampin) due to increased rate of metabolism of these substances.

Inhibitors of the function of the adrenal cortex (including mitotan) may necessitate higher doses of GCS.

Clearance GCS increased against the background of preparations of thyroid hormones.

Immunosuppressants increase the risk of infection and lymphoma or other lymphoproliferative disorders associated with Epstein-Barr virus.

Estrogens (including oral contraceptives containing estrogen) reduce the clearance of GKS, lengthens T1/2 and their therapeutic and toxic effects. The appearance of hirsutism and acne promotes the simultaneous use of other steroid hormone funds - androgens, estrogens, anabolic steroids, oral contraceptives.

Tricyclic antidepressants may increase the severity of depression caused by GCS (not shown for the treatment of these side effects).

The risk of developing cataracts increases with the application against other GCS antipsychotic funds (neuroleptics), carbutamide and azathioprine. Simultaneous of Hydrocortisyl ICM Pharma with the appointment of m-cholinoblockers, as well as with means having m-anticholinergic action (including antihistamines, tricyclic antidepressants), with nitrates improves the intraocular pressure.

With simultaneous application of SCS with live vaccines and antiviral compared to other types of immunization increases the risk of activation of viruses and development of infections.

Hydrocortisyl side effects

Applies to Hydrocortisyl: oral suspension, oral tablet

In addition to its needed effects, some unwanted effects may be caused by Hydrocortisyl. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Hydrocortisyl:

More common:

  • Aggression
  • agitation
  • anxiety
  • blurred vision
  • decrease in the amount of urine
  • dizziness
  • fast, slow, pounding, or irregular heartbeat or pulse
  • headache
  • irritability
  • mental depression
  • mood changes
  • nervousness
  • noisy, rattling breathing
  • numbness or tingling in the arms or legs
  • pounding in the ears
  • shortness of breath
  • swelling of the fingers, hands, feet, or lower legs
  • trouble thinking, speaking, or walking
  • troubled breathing at rest
  • weight gain
Incidence not known:
  • Abdominal cramping and/or burning (severe)
  • abdominal pain
  • backache
  • bloody, black, or tarry stools
  • cough or hoarseness
  • darkening of skin
  • decrease in height
  • decreased vision
  • diarrhea
  • dry mouth
  • eye pain
  • eye tearing
  • facial hair growth in females
  • fainting
  • fatigue
  • fever or chills
  • flushed, dry skin
  • fractures
  • fruit-like breath odor
  • full or round face, neck, or trunk
  • heartburn and/or indigestion (severe and continuous)
  • increased hunger
  • increased thirst
  • increased urination
  • loss of appetite
  • loss of sexual desire or ability
  • lower back or side pain
  • menstrual irregularities
  • muscle pain or tenderness
  • muscle wasting or weakness
  • nausea
  • pain in back, ribs, arms, or legs
  • painful or difficult urination
  • skin rash
  • sleeplessness
  • sweating
  • trouble healing
  • trouble sleeping
  • unexplained weight loss
  • unusual tiredness or weakness
  • vision changes
  • vomiting
  • vomiting of material that looks like coffee grounds

Minor Side Effects

Some of the side effects that can occur with Hydrocortisyl may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

  • Increased appetite
Incidence not known:
  • Abnormal fat deposits on the face, neck, and trunk
  • acne
  • dry scalp
  • lightening of normal skin color
  • red face
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • swelling of the stomach area
  • thinning of the scalp hair

Hydrocortisyl contraindications

For short-term use of Hydrocortisyl Sunward Pharmaceutical according to the life - hypersensitivity to Hydrocortisyl. For intraarticular administration and injection directly into the lesion: previous arthroplasty, abnormal bleeding (endogenous or caused by the use of anticoagulants), intra-articular fracture, infection (septic) inflammatory process in joints and periarticular infections (including history), and also general infectious disease marked juxta-articular osteoporosis, lack of signs of inflammation in the joint ("dry" joint, such as osteoarthrosis without synovitis), marked bone destruction and deformity of joints (sharp narrowing of joint space, ankylosis), instability of the joint as a result of arthritis, aseptic necrosis of the epiphyses of bones forming the joint.

For external use: bacterial, viral, fungal skin diseases, tuberculosis, skin, cutaneous manifestations of syphilis, tumors of the skin, post-vaccination period, violation of the integrity of the skin (ulcers, wounds), children's age (up to 2 years, with itching in the anal area - up to 12 years), rosacea, acne vulgaris, perioral dermatitis.

For use in ophthalmology: bacterial, viral, fungal eye diseases, tuberculosis eye disease, trachoma, violation of the integrity of the eye epithelium.



Active ingredient matches for Hydrocortisyl:

Hydrocortisone in Ethiopia, Ireland, Malta.

Hydrocortisone Acetate


List of Hydrocortisyl substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Injectable; Injection; Hydrocortisone Acetate 2.5% (Sovereign)
Injectable; Injection; Hydrocortisone Sodium Phosphate 25 mg / ml (Auden mckenzie)
Injectable; Injection; Hydrocortisone Sodium Phosphate 50 mg / ml (Auden mckenzie)
Ointment; Ophthalmic, Otic; Hydrocortisone Sodium Phosphate 1.5% (Auden mckenzie)
Tablet; Oral; Hydrocortisone Sodium Phosphate 10 mg (Auden mckenzie)
Tablet; Oral; Hydrocortisone Sodium Phosphate 20 mg (Auden mckenzie)
Tablets; Oral; Hydrocortisone Sodium Phosphate 10 mg (Auden mckenzie)
Tablets; Oral; Hydrocortisone Sodium Phosphate 20 mg (Auden mckenzie)
Ointment; Topical; Hydrocortisone Acetate 1% (Dermapharm)
Ointment; Topical; Hydrocortisone 1% (Dermapharm)
Cream; Topical; Hydrocortisone 0.5% (Karrer)
Cream; Topical; Hydrocortisone (Galen)
Lotion; Topical; Hydrocortisone (Galen)
Ointment; Topical; Hydrocortisone (Galen)
Solution; Topical; Hydrocortisone (Galen)
HYDROLIN 100MG INJECTION 1 vial / 1 injection each (Hetero Drugs Ltd)$ 0.66
Hydroskin cream 1 g/100g (Rugby)
Hydroskin lotion 1 g/100mL (Rugby)
Cream; Topical; Hydrocortisone 0.5% (Christo)
Hydrosone 1 % x 15 g (Christo)
Hydrosone 1 % x 450 g (Christo)
Cream; Topical; Hydrocortisone 1% (Christo)
Hydrotopic / Vial 100 mg x 10's (Vendiz)$ 26.44

References

  1. DailyMed. "CIPROFLOXACIN HYDROCHLORIDE; HYDROCORTISONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "hydrocortisone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "hydrocortisone". http://www.drugbank.ca/drugs/DB00741 (accessed September 17, 2018).
  4. DTP/NCI. "hydrocortisone: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
  5. Wikipedia. "cortisol: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Cortis... (accessed September 17, 2018).

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The results of a survey conducted on ndrugs.com for Hydrocortisyl are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hydrocortisyl. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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