Hygroton is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.
Hygroton is also used to treat fluid retention (edema) that is caused by congestive heart failure, severe liver disease (cirrhosis), kidney disease, or treatment with a hormone or steroid medicine.
Hygroton is a diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps to lower blood pressure.
Hygroton is available only with your doctor's prescription.
Hygroton indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Treatment of arterial hypertension, essential or nephrogenic or isolated systolic. Treatment of stable, chronic heart failure of mild to moderate degree (New York Heart Association, NYHA: functional class II or III).
Oedema of specific origin
• Ascites due to cirrhosis of the liver in stable patients under close control.
• Oedema due to nephrotic syndrome.
Diabetes Insipidus.
How should I use Hygroton?
Use Hygroton as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Take Hygroton by mouth with food, preferably in the morning.
Hygroton will increase urination. If you are taking 1 dose of Hygroton daily, take it in the morning to prevent this from affecting your sleep.
If you miss a dose of Hygroton, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Hygroton.
Uses of Hygroton in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications
Edema: Adjunctive treatment of edema associated with heart failure, renal impairment, hepatic cirrhosis, or corticosteroid and estrogen therapy.
Hypertension: Management of hypertension.
Guideline recommendations: The 2017 Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults recommends if monotherapy is warranted, in the absence of comorbidities (eg, cerebrovascular disease, chronic kidney disease, diabetes, heart failure, ischemic heart disease, etc), that thiazide-like diuretics or dihydropyridine calcium channel blockers may be preferred options due to improved cardiovascular endpoints (eg, prevention of heart failure and stroke). ACE inhibitors and ARBs are also acceptable for monotherapy. Combination therapy may be required to achieve blood pressure goals and is initially preferred in patients at high risk (stage 2 hypertension or atherosclerotic cardiovascular disease [ASCVD] risk ≥10%) (ACC/AHA [Whelton 2017]).
Off Label Uses
Calcium nephrolithiasis
Data from a prospective, double-blind, randomized, placebo-controlled study support the use of Hygroton for the prevention of recurrent calcium nephrolithiasis.
Based on the European Society of Endocrinology consensus statement on the standards of care for hypoparathyroidism in adults, the Endocrine Society guidelines on the management of hypoparathyroidism, and the European Society of Endocrinology guidelines on the treatment of chronic hypoparathyroidism, Hygroton, usually in combination with a low-salt diet, may be considered in the management of chronic hypoparathyroidism to reduce urinary calcium losses.
Hygroton description
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A benzenesulfonamide-phthalimidine that tautomerizes to a benzophenones form. It is considered a thiazide-like diuretic. [PubChem]
Hygroton dosage
Hygroton Dosage
Applies to the following strength(s): 50 mg; 25 mg; 100 mg; 15 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
Edema
Hypertension
Additional dosage information:
Renal Dose Adjustments
Liver Dose Adjustments
Dose Adjustments
Precautions
Dialysis
Other Comments
Usual Adult Dose for Edema
Initial dose: 50-100 mg orally once a day.
Maintenance dose: 25-100 mg once a day or
50-200 mg every other day.
Usual Adult Dose for Hypertension
Initial dose: 25 mg orally once a day (15 mg for Thalitone).
Maintenance dose: 25-100 mg once a day (15-50 mg for Thalitone).
Renal Dose Adjustments
Hygroton is not expected to be filtered into the renal tubule (its site of action) when the glomerular filtration rate is less than 10 mL/min.
Liver Dose Adjustments
Data not available
Dose Adjustments
Dosage adjustments are recommended to be made no more frequently than weekly. Patients with liver disease or renal dysfunction should have dosage adjustments made cautiously.
Precautions
Hygroton is contraindicated in patients with anuria.
Hygroton therapy should be used with caution in severe renal disease. In patients with renal disease, Hygroton or related drugs may precipitate azotemia. Cumulative effects may develop in patients with impaired renal function. If progressive renal impairment becomes evident, as indicated by a rising nonprotein nitrogen or blood urea nitrogen, a careful reappraisal of the treatment is necessary with consideration given to withholding or discontinuing diuretic therapy.
Hygroton therapy should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
Sensitivity reactions may be observed in patients with a history of allergy or bronchial asthma.
The possibility of exacerbation or activation of systemic lupus erythematosus has been observed with thiazide diuretics, which are structurally related to Hygroton. However, systemic lupus erythematosus has not been observed following Hygroton administration.
Hypokalemia may develop with Hygroton as with any other diuretic, especially with brisk diuresis when severe cirrhosis is present. Interference with adequate oral electrolyte intake will also contribute to hypokalemia.
Any chloride deficit is generally mild and usually does not require specific therapy except under extraordinary circumstances (as in liver disease or renal disease). Dilutional hyponatremia may be observed in edematous patients in hot weather, appropriate therapy is water restriction, rather than administration of salt except in rare instances when the hyponatremia is life threatening. In actual salt depletion, appropriate replacement is the treatment of choice.
Hyperuricemia may occur or frank gout may be precipitated in certain patients receiving Hygroton therapy. Thiazide-like diuretics have been shown to increase the urinary excretion of magnesium, which may result in hypomagnesemia.
The antihypertensive effects Hygroton may be enhanced in the post-sympathectomy patient.
Calcium excretion is decreased by thiazide-like agents. Pathological changes in the parathyroid gland with hypercalcemia and hypophosphatemia have been reported in few patients on thiazide therapy. The common complications of hyperparathyroidism such as renal lithiasis, bone resorption and peptic ulceration have not been observed.
Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be conducted at appropriate intervals.
Electrolyte abnormalities (i.e., hypokalemia, hyponatremia) and glucose intolerance may occur during Hygroton therapy.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
Data not available
Other Comments
The maximum daily dose for hypertension is 100 mg (50 mg for Thalitone).
The maximum daily dose for edema is 200 mg (120 mg for Thalitone).
Periodic monitoring of electrolytes is recommended, particularly in elderly patients and in patients receiving a high dose.
In addition to its needed effects, some unwanted effects may be caused by Hygroton (the active ingredient contained in Hygroton). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Hygroton:
Incidence not known:
Abdominal or stomach pain
black, tarry stools
bleeding gums
blistering, peeling, or loosening of skin
bloating
blood in urine or stools
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest pain
chills
clay-colored stools
cold sweats
confusion
constipation
cough or hoarseness
coughing up blood
darkened urine
diarrhea
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
dry mouth
fast heartbeat
fatigue
fever
flushed, dry skin
fruit-like breath odor
general feeling of tiredness or weakness
headache
increased hunger
increased thirst
increased urination
indigestion
itching
joint pain, stiffness, or swelling
loss of appetite
lower back or side pain
nausea
pain in joints or muscles
painful or difficult urination
pains in stomach, side, or abdomen, possibly radiating to the back
pinpoint red spots on skin
red irritated eyes
red skin lesions, often with a purple center
redness, soreness or itching skin
shortness of breath
skin rash
sore throat
sores, ulcers, or white spots on lips or in mouth
sores, welting, or blisters
sugar in the urine
sweating
swelling of feet or lower legs
swollen glands
tightness in chest
troubled breathing
unpleasant breath odor
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight loss
vomiting
vomiting of blood
weight loss
wheezing
yellow eyes or skin
Minor Side Effects
Some of the side effects that can occur with Hygroton may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
Incidence not known:
Cramping
decreased interest in sexual intercourse
difficulty having a bowel movement (stool)
feeling of constant movement of self or surroundings
hives
inability to have or keep an erection
increased sensitivity of skin to sunlight
loss in sexual ability, desire, drive, or performance
Hypersensitivity to Hygroton, other sulfonamide-derived drugs, or any component of the formulation; anuria
Note: Although the FDA approved product labeling states this medication is contraindicated with other sulfonamide-containing drug classes, the scientific basis of this statement has been challenged. See "Warnings/Precautions" for more detail.
Documentation of allergenic cross-reactivity for drugs thiazide-type diuretics is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.
Active ingredient matches for Hygroton:
Chlorthalidone in Argentina, Australia, Bahrain, Belgium, Bosnia & Herzegowina, Croatia (Hrvatska), Germany, Ghana, Greece, Guyana, Hungary, Indonesia, Japan, Kenya, Libya, Luxembourg, New Zealand, Nigeria, Oman, Poland, Portugal, Slovenia, Sudan, Switzerland, Tanzania, United Kingdom, Zimbabwe.
DailyMed. "ATENOLOL; CHLORTHALIDONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
The results of a survey conducted on ndrugs.com for Hygroton are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hygroton. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
Consumer reported useful
No survey data has been collected yet
Consumer reported price estimates
No survey data has been collected yet
1 consumer reported time for results
To what extent do I have to use Hygroton before I begin to see changes in my health conditions? As part of the reports released by ndrugs.com website users, it takes 2 weeks and a few days before you notice an improvement in your health conditions. Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Hygroton. To get the time effectiveness of using Hygroton drug by other patients, please click here.
Users
%
2 weeks
1
100.0%
Consumer reported age
No survey data has been collected yet
Consumer reviews
There are no reviews yet. Be the first to write one!
