Hyperstat Uses

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What is Hyperstat?

Hyperstat raises blood sugar by slowing the release of insulin from the pancreas.

Hyperstat is used to treat low blood sugar (hypoglycemia) caused by certain cancers or other conditions that can make the pancreas release too much insulin.

Hyperstat may also be used for purposes not listed in this medication guide.

Hyperstat indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Hyperstat (ORAL Hyperstat) is useful in the management of hypoglycemia due to hyperinsulinism associated with the following conditions:

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Adults: Inoperable islet cell adenoma or carcinoma, or extrapancreatic malignancy.
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Infants and Children: Leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, or adenomatosis. Hyperstat may be used preoperatively as a temporary measure, and postoperatively, if hypoglycemia persists.

Hyperstat should be used only after a diagnosis of hypoglycemia due to one of the above conditions has been definitely established. When other specific medical therapy or surgical management either has been unsuccessful or is not feasible, treatment with Hyperstat should be considered.

How should I use Hyperstat?

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use Hyperstat suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Shake well before using.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • Hyperstat suspension works best if it is taken on a regular schedule.
  • Continue to use Hyperstat suspension even if you feel well. Do not miss any doses.
  • If you miss a dose of Hyperstat suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hyperstat suspension.

Hyperstat description

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A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. [PubChem]

Hyperstat dosage

HYPERSTAT I.V. Injection was originally recommended for use by bolus administration of 300 mg. Recent studies have shown that minibolus administration of HYPERSTAT I.V. Injection, ie, doses of 1 to 3 mg/kg repeated at intervals of 5 to 15 minutes is as effective in reducing blood pressure. Minibolus administration usually provides a more gradual reduction in blood pressure and thus may be expected to reduce the circulatory and neurological risks associated with acute hypotension.

HYPERSTAT I.V. Injection is administered undiluted and rapidly by intravenous injections of 1 to 3 mg/kg up to a maximum of 150 mg in a single injection. This dose may be repeated at intervals of 5 to 15 minutes until a satisfactory reduction in blood pressure (diastolic pressure below 100 mmHg) has been achieved.

With the patient recumbent, the calculated dose of HYPERSTAT I.V. Injection is administered intravenously in 30 seconds or less.

HYPERSTAT I.V. Injection should only be given into a peripheral vein. Do not administer it intramuscularly, subcutaneously, or into body cavities. Avoid extravasation of the drug into subcutaneous tissues.

Following the use of HYPERSTAT I.V. Injection, the blood pressure should be monitored closely until it has stabilized. Thereafter, measurements taken hourly during the balance of the effect should indicate any unusual response. A further decrease in blood pressure 30 minutes or more after injection should be investigated for causes other than the action of HYPERSTAT I.V. Injection. It is preferable that the patient remain supine for at least 1 hour after injection. In ambulatory patients, the blood pressure should also be measured with the patient standing before surveillance is ended.

Repeated administration of HYPERSTAT I.V. Injection at intervals of 4 to 24 hours usually will maintain the blood pressure below pretreatment levels until a regimen of oral antihypertensive medication can be instituted. The interval between injections may be adjusted by the duration of the response to each injection. It is usually unnecessary to continue treatment with HYPERSTAT I.V. Injection for more than 4 to 5 days.

Since repeated administration of HYPERSTAT I.V. Injection can lead to sodium and water retention, administration of a diuretic may be necessary both for maximal blood pressure reduction and to avoid congestive heart failure.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Hyperstat interactions

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Enhanced hyperglycaemic, hyperuricemic or hypotensive effects w/ diuretics. Increased risk of hypotension w/ other antihypertensive drugs or vasodilators. Increased risk of hyperglycaemia w/ concomitant phenytoin, corticosteroids or oestrogen-progestogen combinations. May displace other highly protein-bound drugs (e.g. coumarin and its derivatives) resulting in higher blood levels of these substances.

Hyperstat side effects

Applies to Hyperstat: oral capsule, oral suspension

In addition to its needed effects, some unwanted effects may be caused by Hyperstat (the active ingredient contained in Hyperstat). In the event that any of these side effects do occur, they may require medical attention.

Stop taking Hyperstat and get emergency help immediately if any of the following effects occur:

Rare

  • Chest pain caused by exercise or activity
  • confusion
  • numbness of the hands
  • shortness of breath (unexplained)

Severity: Moderate

If any of the following side effects occur while taking Hyperstat, check with your doctor or nurse as soon as possible:

More common:

  • Decreased urination
  • swelling of feet or lower legs
  • weight gain (rapid)
Less common:
  • Fast heartbeat
Rare
  • Fever
  • skin rash
  • stiffness of arms or legs
  • trembling and shaking of hands and fingers
  • unusual bleeding or bruising

Minor Side Effects

Some of the side effects that can occur with Hyperstat may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

  • Changes in ability to taste
  • constipation
  • increased hair growth on forehead, back, arms, and legs
  • loss of appetite
  • nausea and vomiting
  • stomach pain

This medicine may cause a temporary increase in hair growth in some people when it is used for a long time. After treatment with Hyperstat has ended, normal hair growth should return.

Hyperstat contraindications

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Hyperstat I.V. Injection should not be used in the treatment of compensatory hypertension, such as that associated with aortic coarctation or arteriovenous shunt, and should not be used in patients hypersensitive to Hyperstat, other thiazides, or other sulfonamide-derived drugs.

Active ingredient matches for Hyperstat:

Diazoxide


Unit description / dosage (Manufacturer)Price, USD
Injectable; Injection; Diazoxide 15 mg / ml
20 milliliter in 1 ampule

List of Hyperstat substitutes (brand and generic names):

Injectable; Injection; Diazoxide 300 mg
Injectable; Injection; Diazoxide 15 mg / ml
Proglycem 50 mg/ml Suspension 30ml Bottle$ 197.05
Diazoxide powder$ 85.07
Proglycem 100 mg Capsule$ 1.65
Diazoxide DBL 300 mg/20 mL x 1's
Tablet, Sugar-Coated; Oral; Diazoxide 50 mg (Mercury)
Capsule; Oral; Diazoxide 25 mg (Essex)
Capsule; Oral; Diazoxide 100 mg (Essex)
Proglicem 25 mg x 100's (Essex)
Proglicem 100 mg x 100's (Essex)
Capsule; Oral; Diazoxide 50 mg (Ifet)
Capsule; Oral; Diazoxide 100 mg (Ifet)
Suspension; Oral; Diazoxide 50 mg / ml (Ifet)
Proglycem 50 mg/1 mL x 30 mL (Ifet)
Proglycem suspension 50 mg/mL (Ifet)
Proglycem capsule 100 mg (Ifet)

References

  1. DailyMed. "DIAZOXIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "diazoxide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "diazoxide". http://www.drugbank.ca/drugs/DB01119 (accessed September 17, 2018).
  4. DTP/NCI. "diazoxide: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
  5. Wikipedia. "diazoxide: Link to the compound information in Wikipedia.". https://en.wikipedia.org/wiki/Diazox... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Hyperstat are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hyperstat. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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